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01-09-2021 | COVID-19 | Topic Paper

Clinical trials in urological oncology: COVID-19 and the potential need for a new perspective

Authors: Jiasian Teh, Ellen O’Connor, Jasamine Coles-Black, Nathan Lawrentschuk

Published in: World Journal of Urology | Issue 9/2021

Abstract

The COVID-19 pandemic has led to the suspension, termination or alteration of thousands of clinical trials as the health emergency escalated globally. Whilst the rapid suspension of certain clinical trials was necessary to ensure the safety of high-risk or vulnerable trial participants as well as healthcare workers, the long-term ramifications that this delay will have on the field of urologic oncology is unknown. The COVID-19 pandemic has highlighted the need to plan for and implement new strategies to advance our understanding of unmet areas of need in urologic oncology. The COVID-19 pandemic has led to the suspension, termination or alteration of thousands of clinical trials as the health emergency escalated globally. Whilst the rapid suspension of certain clinical trials was necessary to ensure the safety of high-risk or vulnerable trial participants as well as healthcare workers, the long-term ramifications that this delay will have on the field of urologic oncology is unknown. The COVID-19 pandemic has highlighted the need to plan for and implement new strategies to advance our understanding of unmet areas of need in urologic oncology.

U.S. National Library of Medicine. ClinicalTrials.gov 2020. https://clinicaltrials.gov/ct2/home. Accessed 13 May 2020

Chen R, Liang W, Jiang M, Guan W, Zhan C, Wang T et al (2020) Risk factors of fatal outcome in hospitalized subjects with coronavirus disease 2019 from a nationwide analysis in China. Chest. https://doi.org/10.1016/j.chest.2020.04.010CrossRefPubMedPubMedCentral

Gostin LO, Friedman EA, Wetter SA (2020) Responding to Covid-19: how to navigate a public health emergency legally and ethically. Hastings Cent Rep 50(2):8–12CrossRef

Parmar MKB, Barthel FMS, Sydes M, Langley R, Kaplan R, Eisenhauer E et al (2008) Speeding up the evaluation of new agents in cancer. J Natl Cancer Inst 100(17):1204–1214CrossRef

Institute NC. The Cancer Genome Atlas Program 2020. https://www.cancer.gov/about-nci/organization/ccg/research/structural-genomics/tcga. Accessed 13 May 2020

Chalmers ZR, Connelly CF, Fabrizio D, Gay L, Ali SM, Ennis R et al (2017) Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden. Genome Med 9(1):34CrossRef

Le DT, Durham JN, Smith KN, Wang H, Bartlett BR, Aulakh LK et al (2017) Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade. Science 357(6349):409CrossRef

Title: Clinical trials in urological oncology: COVID-19 and the potential need for a new perspective
Authors: Jiasian Teh
Ellen O’Connor
Jasamine Coles-Black
Nathan Lawrentschuk
Publication date: 01-09-2021
Publisher: Springer Berlin Heidelberg
Keyword: COVID-19
Published in: World Journal of Urology / Issue 9/2021
Print ISSN: 0724-4983
Electronic ISSN: 1433-8726
DOI: https://doi.org/10.1007/s00345-020-03416-4

At a glance: The STEP trials

Springer Medicine

Clinical trials in urological oncology: COVID-19 and the potential need for a new perspective

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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