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World Journal of Urology

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01-09-2021 | Acute Kidney Injury | Topic Paper

A systematic review on COVID-19: urological manifestations, viral RNA detection and special considerations in urological conditions

Authors: Vinson Wai-Shun Chan, Peter Ka-Fung Chiu, Chi-Hang Yee, Yuhong Yuan, Chi-Fai Ng, Jeremy Yuen-Chun Teoh

Published in: World Journal of Urology | Issue 9/2021

Abstract

Purpose and objective

We performed a systematic review on COVID-19 and its potential urological manifestations.

Methods

A literature search was performed using combination of keywords (MeSH terms and free text words) relating to COVID-19, urology, faeces and stool on multiple databases. Primary outcomes were the urological manifestations of COVID-19, and SARS-CoV-2 viral RNA detection in urine and stool samples. Meta-analyses were performed when there were two or more studies reporting on the same outcome. Special considerations in urological conditions that were relevant in the pandemic of COVID-19 were reported in a narrative manner.

Results

There were a total of 21 studies with 3714 COVID-19 patients, and urinary symptoms were absent in all of them. In patients with COVID-19, 7.58% (95% CI 3.30–13.54%) developed acute kidney injury with a mortality rate of 93.27% (95% CI 81.46–100%) amongst them. 5.74% (95% CI 2.88–9.44%) of COVID-19 patients had positive viral RNA in urine samples, but the duration of viral shedding in urine was unknown. 65.82% (95% CI 45.71–83.51%) of COVID-19 patients had positive viral RNA in stool samples, which were detected from 2 to 47 days from symptom onset. 31.6% of renal transplant recipients with COVID-19 required non-invasive ventilation, and the overall mortality rate was 15.4%.

Conclusions

Acute kidney injury leading to mortality is common amongst COVID-19 patients, likely as a result of direct viral toxicity. Viral RNA positivity was detected in both urine and stool samples, so precautions are needed when we perform transurethral or transrectal procedures.

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Title: A systematic review on COVID-19: urological manifestations, viral RNA detection and special considerations in urological conditions
Authors: Vinson Wai-Shun Chan
Peter Ka-Fung Chiu
Chi-Hang Yee
Yuhong Yuan
Chi-Fai Ng
Jeremy Yuen-Chun Teoh
Publication date: 01-09-2021
Publisher: Springer Berlin Heidelberg
Keywords: Acute Kidney Injury
SARS-CoV-2
COVID-19
Acute Kidney Injury
Mycophenolate Mofetil
Tacrolimus
Published in: World Journal of Urology / Issue 9/2021
Print ISSN: 0724-4983
Electronic ISSN: 1433-8726
DOI: https://doi.org/10.1007/s00345-020-03246-4

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

A systematic review on COVID-19: urological manifestations, viral RNA detection and special considerations in urological conditions

Abstract

Purpose and objective

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose and objective

Methods

Results

Conclusions

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