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World Journal of Urology
Published in: World Journal of Urology 4/2020

01-04-2020 | Tadalafile | Original Article

Role of phosphodiesterase inhibitors in stent-related symptoms: a systematic review and meta-analysis

Authors: Gopal Sharma, Aditya Prakash Sharma, Ravimohan S. Mavuduru, Sudheer K. Devana, Girdhar Singh Bora, Shrawan K. Singh, Arup K. Mandal

Published in: World Journal of Urology | Issue 4/2020

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Abstract

Purpose

Stent-related symptoms are frequent following stent placement for various indications. Use of PDE inhibitors has expanded beyond their classical indication and has been tried in patients with stent-related symptoms. The systematic review was conducted to ascertain the efficacy of PDE inhibitors in ameliorating stent-related symptoms.

Methods

We performed systematic review and metanalysis on the use of PDE inhibitors for stent-related symptoms in patients who underwent stent placement for various reasons (postpercutaneous nephrolithotomy or ureterorenoscopy). We followed PRISMA guidelines while conducting this review and study protocol was registered with PROSPERO (CRD42019121781)

Results

Three studies with 280 participants were included in this review. There was considerable heterogeneity across all the outcome parameters assessed; thus, random-effect model was used for analysis. Comparison of PDE inhibitors with control arm revealed that PDE inhibitors were significantly more effective than placebo in all but one domain (Work performance) of the USSQ. On comparison with alfa blockers, PDE inhibitors were found to be equally effective for urinary symptoms, general health, and body pain parameters, but sexual health parameters improved significantly with PDE inhibitors.

Conclusion

PDE inhibitors can be considered an option for patients with stent-related symptoms especially in patients with sexual dysfunction. Due to various limitations of the studies included in this review, we recommend conducting further high-quality studies.
Appendix
Available only for authorised users
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Metadata
Title
Role of phosphodiesterase inhibitors in stent-related symptoms: a systematic review and meta-analysis
Authors
Gopal Sharma
Aditya Prakash Sharma
Ravimohan S. Mavuduru
Sudheer K. Devana
Girdhar Singh Bora
Shrawan K. Singh
Arup K. Mandal
Publication date
01-04-2020
Publisher
Springer Berlin Heidelberg
Published in
World Journal of Urology / Issue 4/2020
Print ISSN: 0724-4983
Electronic ISSN: 1433-8726
DOI
https://doi.org/10.1007/s00345-019-02862-z

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