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World Journal of Urology
Published in: World Journal of Urology 9/2019

01-09-2019 | Original Article

RAB38 promotes bladder cancer growth by promoting cell proliferation and motility

Authors: Da-Wei Tian, Sheng-Lai Liu, Li-Ming Jiang, Zhou-Liang Wu, Jie Gao, Hai-Long Hu, Chang-Li Wu

Published in: World Journal of Urology | Issue 9/2019

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Abstract

Background

Bladder cancer is the most common malignancy of urinary system with high morbidity and mortality. In general, the development and progression of bladder cancer are complicated pathological processes, and the treatment methods mainly include surgical resection, radiotherapy, chemotherapy, and combined therapy. In recent years, targeted therapy has made progress in the treatment of bladder cancer. Therefore, to improve survival rates of patients with advanced bladder cancer, novel therapeutic targets are still urgently needed.

Methods and results

In this study, we found that RAB38 expressed in tumor tissues of patients with bladder cancer was linked to clinical features including pTNM stage and tumor recurrence, and positively correlated with the poor prognosis of bladder cancer. Notably, further results indicated that depletion of RAB38 could significantly inhibit the proliferation and motility of two types of human bladder cancer cells, T24 and 5637 cells. In addition, RAB38 ablation obviously blocked tumor growth and development in mice compared with control.

Conclusion

In conclusion, this study provides significant evidence that RAB38 promotes the development of bladder cancer and provides a novel therapeutic target of bladder cancer.
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Metadata
Title
RAB38 promotes bladder cancer growth by promoting cell proliferation and motility
Authors
Da-Wei Tian
Sheng-Lai Liu
Li-Ming Jiang
Zhou-Liang Wu
Jie Gao
Hai-Long Hu
Chang-Li Wu
Publication date
01-09-2019
Publisher
Springer Berlin Heidelberg
Published in
World Journal of Urology / Issue 9/2019
Print ISSN: 0724-4983
Electronic ISSN: 1433-8726
DOI
https://doi.org/10.1007/s00345-018-2596-9

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