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World Journal of Urology

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01-08-2018 | Original Article

Effects of testosterone supplement treatment in hypogonadal adult males with T2DM: a meta-analysis and systematic review

Authors: Jianzhong Zhang, Bin Yang, Wenhui Xiao, Xiao Li, Hongjun Li

Published in: World Journal of Urology | Issue 8/2018

Abstract

Purpose

Testosterone supplement treatment (TST) is a classic therapy for hypogonadal men with type 2 diabetes mellitus (T2DM), but the effects of TST in different studies are inconsistent. We conducted this meta-analysis to evaluate the precise role of TST in hypogonadal men with T2DM.

Methods

PubMed, Embase, Cochrane Library and Web of Science were searched to identify qualified randomized controlled trials (RCTs). Pooled mean differences (MDs) with 95% confidence intervals (CIs) were calculated to measure the specific effects of TST. Trial sequential analysis was performed to verify the pooled results.

Results

A total of eight RCTs were enrolled in our meta-analysis, including 596 hypogonadal participants with T2DM. Compared with comparators, TST can significantly improve glycemic control by reducing homeostatic model assessment of insulin resistance (MD − 0.79, 95% CI − 1.23 to − 0.34), fasting glucose (MD − 0.98, 95% CI − 1.13 to − 0.54), fasting insulin (MD − 2.47, 95% CI − 3.99 to − 0.95) and HbA1c% (MD − 0.45, 95% CI − 0.73 to − 0.16). In addition, TST can result in a decline in cholesterol (MD − 0.29, 95% CI − 0.38 to − 0.19) and triglyceride (MD − 0.37, 95% CI − 0.59 to − 0.15).

Conclusion

Our results indicated that TST can improve glycemic control and decrease TC and TG in hypogonadal patients with T2DM. We recommend TST during the anti-diabetic therapy in these patients.

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Title: Effects of testosterone supplement treatment in hypogonadal adult males with T2DM: a meta-analysis and systematic review
Authors: Jianzhong Zhang
Bin Yang
Wenhui Xiao
Xiao Li
Hongjun Li
Publication date: 01-08-2018
Publisher: Springer Berlin Heidelberg
Published in: World Journal of Urology / Issue 8/2018
Print ISSN: 0724-4983
Electronic ISSN: 1433-8726
DOI: https://doi.org/10.1007/s00345-018-2256-0

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Effects of testosterone supplement treatment in hypogonadal adult males with T2DM: a meta-analysis and systematic review

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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