Top

Published in:

01-01-2018 | Original Article

Management of renal transplant urolithiasis: a multicentre study by the French Urology Association Transplantation Committee

Authors: J. Branchereau, M. O. Timsit, Y. Neuzillet, T. Bessède, R. Thuret, M. Gigante, X. Tillou, R. Codas, J. Boutin, A. Doerfler, F. Sallusto, T. Culty, V. Delaporte, N. Brichart, B. Barrou, L. Salomon, G. Karam, J. Rigaud, L. Badet, F. Kleinklauss

Published in: World Journal of Urology | Issue 1/2018

Abstract

Purpose

Urolithiasis is rare among renal transplant recipients and its management has not been clearly defined.

Methods

This multicentre retrospective study was organised by the Comité de Transplantation de l’Association Française d’Urologie (French Urology Association transplantation committee). Statistical analysis was performed with SPSS 19 software.

Results

Ninety-five patients were included in this study. Renal transplant urolithiasis was an incidental finding in 55% of cases, mostly on a routine follow-up ultrasound examination. One half of symptomatic stones were due to urinary tract infection and the other half were due to an episode of acute renal failure. The initial management following diagnosis of urolithiasis was double J stenting (27%), nephrostomy tube placement (21%), or watchful waiting (52%). Definitive management consisted of: watchful waiting (48%), extracorporeal lithotripsy (13%), rigid or flexible ureteroscopy (26%), percutaneous nephrolithotomy (11%) and surgical pyelotomy (2%). All transplants remained functional following treatment of the stone. The main limitation is the retrospective design.

Conclusions

The incidence of lithiasis could be higher in kidney transplanted patients due to a possible anatomical or metabolical abnormalities. The therapeutic management of renal transplant urolithiasis appears to be comparable to that of native kidney urolithiasis.

Abbott KC et al (2003) Hospitalized nephrolithiasis after renal transplantation in the United States. Am J Transplant 3(4):465–470PubMedCrossRef

Challacombe B et al (2005) Multimodal management of urolithiasis in renal transplantation. BJU Int 96(3):385–389PubMedCrossRef

Klingler HC et al (2002) Urolithiasis in allograft kidneys. Urology 59(3):344–348PubMedCrossRef

Kehinde EO et al (2000) Complications associated with using nonabsorbable sutures for ureteroneocystostomy in renal transplant operations. Transplant Proc 32(7):1917–1918PubMedCrossRef

Benoit G et al (1996) Occurrence and treatment of kidney graft lithiasis in a series of 1500 patients. Clin Transplant 10(2):176–180PubMed

Torrecilla Ortiz C et al (2001) Incidence and treatment of urinary lithiasis in renal transplantation. Actas Urol Esp 25(5):357–363PubMedCrossRef

Stapenhorst L et al (2005) Hypocitraturia as a risk factor for nephrocalcinosis after kidney transplantation. Pediatr Nephrol 20(5):652–656PubMedCrossRef

Canas G (2003) Quiz page Stones in the kidney allograft and bladder. Nephrolithiasis is common after transplantation. Cyclosporine often leads to chronic hyperuricemia and the formation of uric acid stones. Am J Kidney Dis 41(1):xliPubMedCrossRef

Faggiano A et al (2003) Nephrolithiasis in Cushing’s disease: prevalence, etiopathogenesis, and modification after disease cure. J Clin Endocrinol Metab 88(5):2076–2080PubMedCrossRef

10.

Guitard J et al (2005) Sulfadiazine-related obstructive urinary tract lithiasis: an unusual cause of acute renal failure after kidney transplantation. Clin Nephrol 63(5):405–407PubMedCrossRef

11.

Delmonico F (2005) A report of the Amsterdam forum on the care of the live kidney donor: data and medical guidelines. Transplantation 79(6 Suppl):S53–S66PubMed

12.

Devasia A et al (2005) Stone-bearing live-donor kidneys for transplantation. BJU Int 95(3):394–397PubMedCrossRef

13.

Lu HF, Shekarriz B, Stoller ML (2002) Donor-gifted allograft urolithiasis: early percutaneous management. Urology 59(1):25–27PubMedCrossRef

14.

Rashid MG et al (2004) Ex vivo ureteroscopic treatment of calculi in donor kidneys at renal transplantation. J Urol 171(1):58–60PubMedCrossRef

15.

Kim H, Cheigh JS, Ham HW (2001) Urinary stones following renal transplantation. Korean J Intern Med 16(2):118–122PubMedPubMedCentralCrossRef

16.

Verrier C et al (2012) Decrease in and management of urolithiasis after kidney transplantation. J Urol 187(5):1651–1655PubMedCrossRef

17.

Poullain J et al (2010) Management of lithiasis of kidney transplant. Prog Urol 20(2):138–143PubMedCrossRef

18.

Lancina Martin JA et al (1997) Urinary lithiasis in transplanted kidney. Arch Esp Urol 50(2):141–150PubMed

19.

Gupta M, Lee MW (2007) Treatment of stones associated with complex or anomalous renal anatomy. Urol Clin North Am 34(3):431–441PubMedCrossRef

20.

Wheatley M et al (1991) Treatment of renal transplant stones by extracorporeal shock-wave lithotripsy in the prone position. Urology 37(1):57–60PubMedCrossRef

21.

Bhadauria RP et al (1995) Donor-gifted allograft lithiasis: extracorporeal shockwave lithotripsy with over table module using the Lithostar Plus. Urol Int 55(1):51–55PubMedCrossRef

22.

Krambeck AE et al (2008) Percutaneous nephrolithotomy success in the transplant kidney. J Urol 180(6):2545–2549PubMedCrossRef

23.

Ferreira Cassini M et al (2012) Lithiasis in 1,313 kidney transplants: incidence, diagnosis, and management. Transplant Proc 44(8):2373–2375PubMedCrossRef

24.

Del Pizzo JJ, Jacobs SC, Sklar GN (1998) Ureteroscopic evaluation in renal transplant recipients. J Endourol 12(2):135–138PubMedCrossRef

25.

Basiri A et al (2006) Ureteroscopic management of urological complications after renal transplantation. Scand J Urol Nephrol 40(1):53–56PubMedCrossRef

26.

Timsit MO et al (2010) Should routine pyeloureterostomy be advocated in adult kidney transplantation? A prospective study of 283 recipients. J Urol 184(5):2043–2048PubMedCrossRef

27.

Hulbert JC et al (1985) The percutaneous removal of calculi from transplanted kidneys. J Urol 134(2):324–326PubMedCrossRef

28.

Crook TJ, Keoghane SR (2005) Renal transplant lithiasis: rare but time-consuming. BJU Int 95(7):931–933PubMedCrossRef

29.

He Z et al (2007) Minimally invasive percutaneous nephrolithotomy for upper urinary tract calculi in transplanted kidneys. BJU Int 99(6):1467–1471PubMedCrossRef

30.

Romero-Vargas L et al (2014) Staghorn stones in renal graft Presentation on two cases report and reviewed bibliography. Arch Esp Urol 67(7):650–653PubMed

Title: Management of renal transplant urolithiasis: a multicentre study by the French Urology Association Transplantation Committee
Authors: J. Branchereau
M. O. Timsit
Y. Neuzillet
T. Bessède
R. Thuret
M. Gigante
X. Tillou
R. Codas
J. Boutin
A. Doerfler
F. Sallusto
T. Culty
V. Delaporte
N. Brichart
B. Barrou
L. Salomon
G. Karam
J. Rigaud
L. Badet
F. Kleinklauss
Publication date: 01-01-2018
Publisher: Springer Berlin Heidelberg
Published in: World Journal of Urology / Issue 1/2018
Print ISSN: 0724-4983
Electronic ISSN: 1433-8726
DOI: https://doi.org/10.1007/s00345-017-2103-8

At a glance: The STEP trials

Springer Medicine

Management of renal transplant urolithiasis: a multicentre study by the French Urology Association Transplantation Committee

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

Please log in to get access to this content

Other articles of this Issue 1/2018

99mTc-HDP bone scintigraphy and 18F-sodiumfluoride PET/CT in primary staging of patients with prostate cancer

Radical prostatectomy or radiotherapy reduce prostate cancer mortality in elderly patients: a population-based propensity score adjusted analysis

Papillary puncture: no way!

Re: Comparison of retroperitoneal and transperitoneal robotic partial nephrectomy for Pentafecta perioperative and renal functional outcomes

Retroperitoneal lymph node dissection for testicular seminomas: population-based practice and survival outcomes

Healthcare utilization in men with poorer sexual and urinary function recovery following robot-assisted radical prostatectomy