Skip to main content
Top
Published in: World Journal of Urology 6/2017

01-06-2017 | Original Article

Multiparametric magnetic resonance imaging for prostate cancer—a comparative study including radical prostatectomy specimens

Authors: Liam Toner, Nathan Papa, Marlon Perera, Nikolas Katelaris, Mahesha Weerakoon, Kwang Chin, Laurence Harewood, Damien M. Bolton, Nathan Lawrentschuk

Published in: World Journal of Urology | Issue 6/2017

Login to get access

Abstract

Purpose

To evaluate the diagnostic and staging ability of multiparametric MRI (mpMRI) compared to radical prostatectomy (RP) specimens after dissemination of this technology to several centres. mpMRI is an evolving technique aiming to improve upon the diagnostic sensitivity of prostate biopsy for the diagnosis of prostate cancer. Differences in interpretation, expertise and application of mpMRI are responsible for the range of reported results.

Methods

This retrospective clinical study was conducted with consecutive patients through an electronic database of tertiary hospitals and adjacent private urology practices in Australia. Patients having undergone RP were assessed for the presence of a pre-operative mpMRI performed between 2013 and 2015 which was evaluated against the reference standard of the RP whole-mount specimen. MRI reports were evaluated using the Prostate Imaging Reporting and Data System (PI-RADS).

Results

In our cohort of 152 patients, the sensitivity and specificity of mpMRI (PI-RADS ≥ 4) for prostate cancer (Gleason ≥ 4 + 3) detection were 83 and 47%, respectively. For the identification of extraprostatic disease, the sensitivity and specificity were 29 and 94%, respectively.

Conclusion

These results represent a ‘real-world’ approach to mpMRI and appear comparable to other single-centre studies. MRI staging information should be interpreted in context with other risk factors for extraprostatic disease. mpMRI has a useful role as an adjunct for prostate cancer diagnosis and directing management towards improving patient outcomes.
Literature
1.
go back to reference Australian Institute of Health and Welfare (2014) Cancer in Australia: an overview 2014. AIHW Cancer Series, Canberra Australian Institute of Health and Welfare (2014) Cancer in Australia: an overview 2014. AIHW Cancer Series, Canberra
2.
go back to reference Grummet JP, Weerakoon M, Huang S, Lawrentschuk N, Frydenberg M, Moon DA et al (2014) Sepsis and ‘superbugs’: Should we favour the transperineal over the transrectal approach for prostate biopsy? BJU Int 114(3):384–388PubMed Grummet JP, Weerakoon M, Huang S, Lawrentschuk N, Frydenberg M, Moon DA et al (2014) Sepsis and ‘superbugs’: Should we favour the transperineal over the transrectal approach for prostate biopsy? BJU Int 114(3):384–388PubMed
3.
go back to reference Chang DTS, Challacombe B, Lawrentschuk N (2013) Transperineal biopsy of the prostate—Is this the future? Nat rev Urol 10(12):690–702CrossRefPubMed Chang DTS, Challacombe B, Lawrentschuk N (2013) Transperineal biopsy of the prostate—Is this the future? Nat rev Urol 10(12):690–702CrossRefPubMed
4.
go back to reference Toner L, Weerakoon M, Bolton DM, Ryan A, Katelaris N, Lawrentschuk N (2015) Magnetic resonance imaging for prostate cancer—comparative studies including radical prostatectomy specimens and template transperineal biopsy. Prostate Int 3(1):107CrossRefPubMedPubMedCentral Toner L, Weerakoon M, Bolton DM, Ryan A, Katelaris N, Lawrentschuk N (2015) Magnetic resonance imaging for prostate cancer—comparative studies including radical prostatectomy specimens and template transperineal biopsy. Prostate Int 3(1):107CrossRefPubMedPubMedCentral
5.
go back to reference Katelaris N, Bolton D, Weerakoon M, Toner L, Katelaris P, Lawrentschuk N (2015) Current role of multiparametric magnetic resonance imaging in the management of prostate cancer. Korean J Urol 56(5):337–345CrossRefPubMedPubMedCentral Katelaris N, Bolton D, Weerakoon M, Toner L, Katelaris P, Lawrentschuk N (2015) Current role of multiparametric magnetic resonance imaging in the management of prostate cancer. Korean J Urol 56(5):337–345CrossRefPubMedPubMedCentral
6.
go back to reference Thompson J, Lawrentschuk N, Frydenberg M, Thompson L, Stricker P (2013) The role of magnetic resonance imaging in the diagnosis and management of prostate cancer. BJU Int 112(Suppl 2):6–20CrossRefPubMed Thompson J, Lawrentschuk N, Frydenberg M, Thompson L, Stricker P (2013) The role of magnetic resonance imaging in the diagnosis and management of prostate cancer. BJU Int 112(Suppl 2):6–20CrossRefPubMed
7.
go back to reference Weinreb JC, Blume JD, Coakley FV, Wheeler TM, Cormack JB, Sotto CK et al (2009) Prostate cancer: sextant localization at MR imaging and MR spectroscopic imaging before prostatectomy-results of ACRIN prospective multi-institutional clinicopathologic study. Radiology 251(1):p122–p133CrossRef Weinreb JC, Blume JD, Coakley FV, Wheeler TM, Cormack JB, Sotto CK et al (2009) Prostate cancer: sextant localization at MR imaging and MR spectroscopic imaging before prostatectomy-results of ACRIN prospective multi-institutional clinicopathologic study. Radiology 251(1):p122–p133CrossRef
8.
go back to reference Johnston R, Wong L-M, Warren A, Shah N, Neal D (2013) The role of 1.5 Tesla magnetic resonance imaging in staging prostate cancer. ANZ J Surg 83(4):234–238CrossRefPubMed Johnston R, Wong L-M, Warren A, Shah N, Neal D (2013) The role of 1.5 Tesla magnetic resonance imaging in staging prostate cancer. ANZ J Surg 83(4):234–238CrossRefPubMed
10.
go back to reference Hamoen EHJ, de Rooij M, Witjes JA, Barentsz J, Rovers M (2015) Use of the prostate imaging reporting and data system (PI-RADS) for prostate cancer detection with multiparametric magnetic resonance imaging: a diagnostic meta-analysis. Eur Urol 67(6):1112–1121CrossRefPubMed Hamoen EHJ, de Rooij M, Witjes JA, Barentsz J, Rovers M (2015) Use of the prostate imaging reporting and data system (PI-RADS) for prostate cancer detection with multiparametric magnetic resonance imaging: a diagnostic meta-analysis. Eur Urol 67(6):1112–1121CrossRefPubMed
11.
go back to reference de Rooij M, Hamoen EHJ, Witjes JA, Barentsz J, Rovers M (2016) Accuracy of magnetic resonance imaging for local staging of prostate cancer: a diagnostic meta-analysis. Eur Urol 70(2):233–245CrossRefPubMed de Rooij M, Hamoen EHJ, Witjes JA, Barentsz J, Rovers M (2016) Accuracy of magnetic resonance imaging for local staging of prostate cancer: a diagnostic meta-analysis. Eur Urol 70(2):233–245CrossRefPubMed
12.
go back to reference Russo F, Regge D, Armando E, Giannini V, Vignati A, Mazzetti S et al (2016) Detection of prostate cancer index lesions with multiparametric magnetic resonance imaging (mp-MRI) using whole-mount histological sections as the reference standard. BJU Int 118(1):84–94CrossRefPubMed Russo F, Regge D, Armando E, Giannini V, Vignati A, Mazzetti S et al (2016) Detection of prostate cancer index lesions with multiparametric magnetic resonance imaging (mp-MRI) using whole-mount histological sections as the reference standard. BJU Int 118(1):84–94CrossRefPubMed
13.
go back to reference Greer M, Brown A, Shih J, Summers R, Marko J, Law Y, et al. (2016) Accuracy and agreement of PIRADSv2 for prostate cancer mpMRI: a multireader study. J Magn Reson Imag. doi:10.1002/jmri.25372 Greer M, Brown A, Shih J, Summers R, Marko J, Law Y, et al. (2016) Accuracy and agreement of PIRADSv2 for prostate cancer mpMRI: a multireader study. J Magn Reson Imag. doi:10.​1002/​jmri.​25372
14.
go back to reference Junker D, Quentin M, Nagele U, Edlinger M, Richenberg J, Schaefer G, et al. (2014) Evaluation of the PI-RADS scoring system for mpMRI of the prostate: a whole-mount step-section analysis. World J Urol 33(7):1023–1030CrossRefPubMed Junker D, Quentin M, Nagele U, Edlinger M, Richenberg J, Schaefer G, et al. (2014) Evaluation of the PI-RADS scoring system for mpMRI of the prostate: a whole-mount step-section analysis. World J Urol 33(7):1023–1030CrossRefPubMed
16.
go back to reference Park S, Oh Y, Jung D, Cho N, Choi Y, Rha K et al (2016) Prediction of biochemical recurrence after radical prostatectomy with PI-RADS version 2 in prostate cancers: initial results. Eur Radiol 26(8):2502–2509CrossRefPubMed Park S, Oh Y, Jung D, Cho N, Choi Y, Rha K et al (2016) Prediction of biochemical recurrence after radical prostatectomy with PI-RADS version 2 in prostate cancers: initial results. Eur Radiol 26(8):2502–2509CrossRefPubMed
17.
go back to reference Pepe P, Garufi A, Priolo G, Pennisi M (2015) Can MRI/TRUS fusion targeted biopsy replace saturation prostate biopsy in the re-evaluation of men in active surveillance? World J Urol 34:1249CrossRefPubMed Pepe P, Garufi A, Priolo G, Pennisi M (2015) Can MRI/TRUS fusion targeted biopsy replace saturation prostate biopsy in the re-evaluation of men in active surveillance? World J Urol 34:1249CrossRefPubMed
18.
go back to reference Osses D, van Asten J, Kieft G, Tijsterman J (2016) Prostate cancer detection rates of magnetic resonance imaging-guided prostate biopsy related to prostate imaging reporting and data system score. World J Urol. doi:10.1007/s00345-016-1874-7 PubMed Osses D, van Asten J, Kieft G, Tijsterman J (2016) Prostate cancer detection rates of magnetic resonance imaging-guided prostate biopsy related to prostate imaging reporting and data system score. World J Urol. doi:10.​1007/​s00345-016-1874-7 PubMed
19.
go back to reference Barrett T, Patterson A, Koo B, Wadhwa K, Warren A, Doble A et al (2016) Targeted transperineal biopsy of the prostate has limited additional benefit over background cores for larger MRI-identified tumors. World J Urol 34(4):501–508CrossRefPubMed Barrett T, Patterson A, Koo B, Wadhwa K, Warren A, Doble A et al (2016) Targeted transperineal biopsy of the prostate has limited additional benefit over background cores for larger MRI-identified tumors. World J Urol 34(4):501–508CrossRefPubMed
20.
go back to reference Pokorny MR, de Rooij M, Duncan E, Schröder FH, Parkinson R, Barentsz JO et al (2014) Prospective study of diagnostic accuracy comparing prostate cancer detection by transrectal ultrasound-guided biopsy versus magnetic resonance (MR) imaging with subsequent MR-guided biopsy in men without previous prostate biopsies. Eur Urol 66(1):22–29CrossRefPubMed Pokorny MR, de Rooij M, Duncan E, Schröder FH, Parkinson R, Barentsz JO et al (2014) Prospective study of diagnostic accuracy comparing prostate cancer detection by transrectal ultrasound-guided biopsy versus magnetic resonance (MR) imaging with subsequent MR-guided biopsy in men without previous prostate biopsies. Eur Urol 66(1):22–29CrossRefPubMed
21.
go back to reference Toner L, Papa N, Aliyu S, Dev H, Lawrentschuk N, Al Hayek S (2015) Extended-spectrum beta-lactamase-producing Enterobacteriaceae in hospital urinary tract infections: incidence and antibiotic susceptibility profile over 9 years. World J Urol 7:1031–1037 Toner L, Papa N, Aliyu S, Dev H, Lawrentschuk N, Al Hayek S (2015) Extended-spectrum beta-lactamase-producing Enterobacteriaceae in hospital urinary tract infections: incidence and antibiotic susceptibility profile over 9 years. World J Urol 7:1031–1037
22.
go back to reference Somford DM, Hamoen EH, Futterer JJ, van Basten JP, Hulsbergen-van de Kaa CA, Vreuls W et al (2013) The predictive value of endorectal 3 Tesla multiparametric magnetic resonance imaging for extraprostatic extension in patients with low, intermediate and high risk prostate cancer. J Urol 190(5):p1728–p1734CrossRef Somford DM, Hamoen EH, Futterer JJ, van Basten JP, Hulsbergen-van de Kaa CA, Vreuls W et al (2013) The predictive value of endorectal 3 Tesla multiparametric magnetic resonance imaging for extraprostatic extension in patients with low, intermediate and high risk prostate cancer. J Urol 190(5):p1728–p1734CrossRef
23.
go back to reference Gupta RT, Faridi KF, Singh AA, Passoni NM, Garcia-Reyes K, Madden JF et al (2014) Comparing 3-T multiparametric MRI and the Partin tables to predict organ-confined prostate cancer after radical prostatectomy. Urol Oncol 32:1292CrossRefPubMed Gupta RT, Faridi KF, Singh AA, Passoni NM, Garcia-Reyes K, Madden JF et al (2014) Comparing 3-T multiparametric MRI and the Partin tables to predict organ-confined prostate cancer after radical prostatectomy. Urol Oncol 32:1292CrossRefPubMed
24.
go back to reference Lawrence E, Gallagher F, Barrett T, Warren A, Priest A, Goldman D et al (2014) Preoperative 3-T diffusion-weighted MRI for the qualitative and quantitative assessment of extracapsular extension in patients with intermediate- or high-risk prostate cancer. AJR Am J Roentgenol 203(3):W280–W286CrossRefPubMed Lawrence E, Gallagher F, Barrett T, Warren A, Priest A, Goldman D et al (2014) Preoperative 3-T diffusion-weighted MRI for the qualitative and quantitative assessment of extracapsular extension in patients with intermediate- or high-risk prostate cancer. AJR Am J Roentgenol 203(3):W280–W286CrossRefPubMed
25.
go back to reference Renard-Penna R, Roupret M, Comperat E, Ayed A, Coudert M, Mozer P et al (2013) Accuracy of high resolution (1.5 tesla) pelvic phased array magnetic resonance imaging (MRI) in staging prostate cancer in candidates for radical prostatectomy: results from a prospective study. Urol Oncol Semin Orig Investig 31(4):448–454CrossRef Renard-Penna R, Roupret M, Comperat E, Ayed A, Coudert M, Mozer P et al (2013) Accuracy of high resolution (1.5 tesla) pelvic phased array magnetic resonance imaging (MRI) in staging prostate cancer in candidates for radical prostatectomy: results from a prospective study. Urol Oncol Semin Orig Investig 31(4):448–454CrossRef
26.
go back to reference Ahmed HU, Emberton M (2009) The role of magnetic resonance imaging in targeting prostate cancer in patients with previous negative biopsies and elevated prostate-specific antigen levels. BJU Int 104(2):269–270CrossRefPubMed Ahmed HU, Emberton M (2009) The role of magnetic resonance imaging in targeting prostate cancer in patients with previous negative biopsies and elevated prostate-specific antigen levels. BJU Int 104(2):269–270CrossRefPubMed
27.
go back to reference Delongchamps NB, Rouanne M, Flam T, Beuvon F, Liberatore M, Zerbib M et al (2011) Multiparametric magnetic resonance imaging for the detection and localization of prostate cancer: combination of T2-weighted, dynamic contrast-enhanced and diffusion-weighted imaging. BJU Int 107(9):1411–1418CrossRefPubMed Delongchamps NB, Rouanne M, Flam T, Beuvon F, Liberatore M, Zerbib M et al (2011) Multiparametric magnetic resonance imaging for the detection and localization of prostate cancer: combination of T2-weighted, dynamic contrast-enhanced and diffusion-weighted imaging. BJU Int 107(9):1411–1418CrossRefPubMed
28.
go back to reference Vaché T, Bratan F, Mège-Lechevallier F, Roche S, Rabilloud M, Rouvière O (2014) Characterization of prostate lesions as benign or malignant at multiparametric MR imaging: comparison of three scoring systems in patients treated with radical prostatectomy. Radiology 272(2):446–455CrossRefPubMed Vaché T, Bratan F, Mège-Lechevallier F, Roche S, Rabilloud M, Rouvière O (2014) Characterization of prostate lesions as benign or malignant at multiparametric MR imaging: comparison of three scoring systems in patients treated with radical prostatectomy. Radiology 272(2):446–455CrossRefPubMed
29.
go back to reference Gaziev G, Wadhwa K, Barrett T, Koo B, Gallagher F, Serrao E et al (2014) Defining the learning curve for multi-parametric MRI of the prostate using MRI-TRUS fusion guided transperineal prostate biopsies as a validation tool. BJU Int 117:80CrossRef Gaziev G, Wadhwa K, Barrett T, Koo B, Gallagher F, Serrao E et al (2014) Defining the learning curve for multi-parametric MRI of the prostate using MRI-TRUS fusion guided transperineal prostate biopsies as a validation tool. BJU Int 117:80CrossRef
Metadata
Title
Multiparametric magnetic resonance imaging for prostate cancer—a comparative study including radical prostatectomy specimens
Authors
Liam Toner
Nathan Papa
Marlon Perera
Nikolas Katelaris
Mahesha Weerakoon
Kwang Chin
Laurence Harewood
Damien M. Bolton
Nathan Lawrentschuk
Publication date
01-06-2017
Publisher
Springer Berlin Heidelberg
Published in
World Journal of Urology / Issue 6/2017
Print ISSN: 0724-4983
Electronic ISSN: 1433-8726
DOI
https://doi.org/10.1007/s00345-016-1960-x

Other articles of this Issue 6/2017

World Journal of Urology 6/2017 Go to the issue