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01-04-2011 | Original Article

Impact of oral anticoagulation on morbidity of transurethral resection of the prostate

Authors: Aurélien Descazeaud, Gregoire Robert, Souhil Lebdai, Alain Bougault, Abdel Rahmene Azzousi, Olivier Haillot, Marian Devonec, Marc Fourmarier, Christian Saussine, Nicolas Barry-Delongchamps, Alexandre de la Taille

Published in: World Journal of Urology | Issue 2/2011

Abstract

Aim

To assess the impact of oral anticoagulation (OA) on morbidity of transurethral resection of the prostate (TURP). OA included warfarin and platelet aggregation inhibitors (PAI).

Patients and Method

Multicenter analysis of patients operated for symptomatic benign prostatic hyperplasia (BPH) by TURP. Patients under OA were compared to those with no OA.

Results

Out of 612 patients included in the analysis, 206 (33%) were on OA prior surgery (55 warfarin, 142 PAI, and 9 warfarin and PAI). No patient continued warfarin and clopidogrel during the operating period. Patients under OA were significantly older (75 vs. 71 yo, P < 0.001), had larger prostate volume (56 vs. 49 ml, P = 0.05), and had higher rate of bladder catheter prior surgery (26 vs. 17%, P = 0.02). At 3 months follow-up, patients in the OA group had a higher weight of resected tissue (24 vs. 21.7 g, P < 0.001), a longer duration of hospitalization (6.4 vs. 4.7 days P < 0.001), a higher rate of bladder clots (13 vs. 4.7%, P < 0.001), red cell transfusion (1.9 vs. 1.0%, P = 0.026), late hematuria (15.0 vs. 8.4%, P = 0.004), and thromboembolic events (2.4 vs. 0.7, P = 0.02). In multivariable analysis, OA status was the sole independent parameter associated with bladder clots (P = 0.004) and with late hematuria (P = 0.03).

Conclusion

OA had a significant and independent impact on TURP outcome in terms of bleeding complications. This data could be used for treatment decision and for patient’s information prior BPH surgery.

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Title: Impact of oral anticoagulation on morbidity of transurethral resection of the prostate
Authors: Aurélien Descazeaud
Gregoire Robert
Souhil Lebdai
Alain Bougault
Abdel Rahmene Azzousi
Olivier Haillot
Marian Devonec
Marc Fourmarier
Christian Saussine
Nicolas Barry-Delongchamps
Alexandre de la Taille
Publication date: 01-04-2011
Publisher: Springer-Verlag
Published in: World Journal of Urology / Issue 2/2011
Print ISSN: 0724-4983
Electronic ISSN: 1433-8726
DOI: https://doi.org/10.1007/s00345-010-0561-3

At a glance: The STEP trials

Springer Medicine

Impact of oral anticoagulation on morbidity of transurethral resection of the prostate

Abstract

Aim

Patients and Method

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Aim

Patients and Method

Results

Conclusion

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