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European Radiology
Published in: European Radiology 11/2020

01-11-2020 | Magnetic Resonance Imaging | Neuro

Texture analysis in susceptibility-weighted imaging may be useful to differentiate acute from chronic multiple sclerosis lesions

Authors: Giovanni Caruana, Lucas M. Pessini, Roberto Cannella, Giuseppe Salvaggio, Andréa de Barros, Annalaura Salerno, Cristina Auger, Àlex Rovira

Published in: European Radiology | Issue 11/2020

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Abstract

Objectives

To evaluate the diagnostic performance of texture analysis (TA) applied on non-contrast-enhanced susceptibility-weighted imaging (SWI) to differentiate acute (enhancing) from chronic (non-enhancing) multiple sclerosis (MS) lesions.

Methods

We analyzed 175 lesions from 58 patients with relapsing-remitting MS imaged on a 3.0 T MRI scanner and applied TA on T2-w and SWI images to extract texture features. We evaluated the presence or absence of lesion enhancement on T1-w post-contrast images and performed a computational statistical analysis to assess if there was any significant correlation between the texture features and the presence of lesion activity. ROC curves and leave-one-out cross-validation were used to evaluate the performance of individual features and multiparametric models in the identification of active lesions.

Results

Multiple TA features obtained from SWI images showed a significantly different distribution in acute and chronic lesions (AUC, 0.617–0.720). Multiparametric predictive models based on logistic ridge regression and partial least squares regression yielded an AUC of 0.778 and 0.808, respectively. Results from T2-w images did not show any significant predictive ability of neither individual features nor multiparametric models.

Conclusions

Texture analysis on SWI sequences may be useful to differentiate acute from chronic MS lesions. The good diagnostic performance could help to reduce the need of intravenous contrast agent administration in follow-up MRI studies.

Key Points

• Texture analysis applied on SWI sequences may be useful to differentiate acute from chronic multiple sclerosis lesions
• The good diagnostic performance could help to minimize the need of intravenous contrast agent administration in follow-up MRI studies
Appendix
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Metadata
Title
Texture analysis in susceptibility-weighted imaging may be useful to differentiate acute from chronic multiple sclerosis lesions
Authors
Giovanni Caruana
Lucas M. Pessini
Roberto Cannella
Giuseppe Salvaggio
Andréa de Barros
Annalaura Salerno
Cristina Auger
Àlex Rovira
Publication date
01-11-2020
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 11/2020
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-020-06995-3

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