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European Radiology

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01-11-2018 | Gastrointestinal

Can quantitative iodine parameters on DECT replace perfusion CT parameters in colorectal cancers?

Authors: Hyo-Jin Kang, Se Hyung Kim, Jae Seok Bae, Sun Kyung Jeon, Joon Koo Han

Published in: European Radiology | Issue 11/2018

Abstract

Objectives

To determine the correlation between iodine concentrations derived from dual-energy CT (DECT) and perfusion CT (PCT) parameters in patients with pathologically proven colorectal cancers (CRC) and to evaluate their reproducibility and respective radiation exposures.

Methods

Institutional review board approval and written informed consents were obtained for this study. Forty-one patients with CRCs who underwent same-day DECT and PCT were prospectively enrolled. Three radiologists independently analyzed the iodine concentration of the tumors and iodine ratios [ratio of lesion to aorta (IRa) or to infrarenal IVC (IRv)] from DECT as well as blood flow (BF), blood volume (BV), permeability (PMB), and mean transit time (MTT) from PCT. Pearson R and linear correlation, paired t-test, and intraclass correlation coefficients (ICCs) were used.

Results

Significant correlations were found between iodine parameters from DECT and PCT parameters: iodine concentration of tumors and BV (r = 0.32, p = 0.04), PMB (r = 0.34, p = 0.03), and MTT (r = -0.38, p = 0.02); iodine ratio (IRa) and MTT (r = -0.32, p = 0.04); iodine ratio (IRv) and BF (r = 0.32, p = 0.04) and PMB (r = 0.44, p = <0.01). DECT showed better intra- and interobserver agreements (ICC = 0.98, 0.90 in iodine concentration; 0.98, 0.91 in IRa; and 0.91, 0.93 in IRv, respectively) than PCT (ICC = 0.90, 0.78 in BF; 0.82, 0.76 in BV; 0.75, 0.75 in PMB; 0.64, 0.79 in MTT, respectively). As for radiation dosage, CTDIvol and DLP in DECT (10.48 ± 1.84 mGy and 519.7 ± 116.7 mGy·cm) were significantly lower than those of PCT (75.76 mGy and 911 mGy·cm) (p < 0.01).

Conclusion

Iodine parameters from DECT are significantly correlated with PCT parameters, but have higher intra- and interobserver agreements and lower radiation exposure.

Key Points

• Quantitative iodine concentrations from DECT are significantly correlated with perfusion CT parameters.

• Intra- and interobserver agreements of DECT are better than those of perfusion CT.

• Effective radiation doses of DECT are significantly lower than those of perfusion CT.

• DECT can be used as an alternative to perfusion CT with lower radiation doses.

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Title: Can quantitative iodine parameters on DECT replace perfusion CT parameters in colorectal cancers?
Authors: Hyo-Jin Kang
Se Hyung Kim
Jae Seok Bae
Sun Kyung Jeon
Joon Koo Han
Publication date: 01-11-2018
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 11/2018
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-018-5502-3

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Can quantitative iodine parameters on DECT replace perfusion CT parameters in colorectal cancers?

Abstract

Objectives

Methods

Results

Conclusion

Key Points

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusion

Key Points

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