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European Radiology
Published in: European Radiology 10/2018

Open Access 01-10-2018 | Magnetic Resonance

Optic radiations are thinner and show signs of iron deposition in patients with long-standing remitting-relapsing multiple sclerosis: an enhanced T2*-weighted angiography imaging study

Authors: Chun Zeng, Silin Du, Yongliang Han, Jialiang Fu, Qi Luo, Yayun Xiang, Xiaoya Chen, Tianyou Luo, Yongmei Li, Yineng Zheng

Published in: European Radiology | Issue 10/2018

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Abstract

Objective

This study aimed to investigate iron deposition and thickness and signal changes in optic radiation (OR) by enhanced T2*-weighted angiography imaging (ESWAN) in patients with relapsing-remitting multiple sclerosis (RRMS) with unilateral and bilateral lesions or no lesions.

Methods

Fifty-one RRMS patients (42 patients with a disease duration [DD] ≥ 2 years [group Mor], nine patients with a DD < 2 years [group Les]) and 51 healthy controls (group Con) underwent conventional magnetic resonance imaging (MRI) and ESWAN at 3.0 T. The mean phase value (MPV) of the OR was measured on the phase image, and thickness and signal changes of the OR were observed on the magnitude image.

Results

The average MPVs for the OR were 1,981.55 ± 7.75 in group Mor, 1,998.45 ± 2.01 in group Les, and 2,000.48 ± 5.53 in group Con. In group Mor, 28 patients with bilateral OR lesions showed bilateral OR thinning with a heterogeneous signal, and 14 patients with unilateral OR lesions showed ipsilateral OR thinning with a heterogeneous signal. In the remaining nine patients without OR lesions and in group Con, the bilateral OR had a normal appearance. In the patients, a negative correlation was found between DD and OR thickness and a positive correlation was found between MPV and OR thickness.

Conclusions

We confirmed iron deposition in the OR in the RRMS patients, and the OR thickness was lower in the patients than in the controls.

Key Points

• Enhanced T 2 * -weighted magnetic resonance angiography (ESWAN) provides new insights into multiple sclerosis (MS).
• Focal destruction of the optic radiation (OR) is detectable by ESWAN.
• Iron deposition in OR can be measured on ESWAN phase image in MS patients.
• OR thickness was lower in the patients than in the controls.
• Iron deposition and thickness changes of the OR are associated with disease duration.
Appendix
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Metadata
Title
Optic radiations are thinner and show signs of iron deposition in patients with long-standing remitting-relapsing multiple sclerosis: an enhanced T2*-weighted angiography imaging study
Authors
Chun Zeng
Silin Du
Yongliang Han
Jialiang Fu
Qi Luo
Yayun Xiang
Xiaoya Chen
Tianyou Luo
Yongmei Li
Yineng Zheng
Publication date
01-10-2018
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 10/2018
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-018-5461-8

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