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European Radiology
Published in: European Radiology 7/2018

01-07-2018 | Computed Tomography

Determination of glomerular filtration rate (GFR) from fractional renal accumulation of iodinated contrast material: a convenient and rapid single-kidney CT-GFR technique

Authors: XiaoDong Yuan, Wei Tang, WenWei Shi, Libao Yu, Jing Zhang, Qing Yuan, Shan You, Ning Wu, Guokun Ao, Tingting Ma

Published in: European Radiology | Issue 7/2018

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Abstract

Objectives

To develop a convenient and rapid single-kidney CT-GFR technique.

Methods

One hundred and twelve patients referred for multiphasic renal CT and 99mTc-DTPA renal dynamic imaging Gates-GFR measurement were prospectively included and randomly divided into two groups of 56 patients each: the training group and the validation group. On the basis of the nephrographic phase images, the fractional renal accumulation (FRA) was calculated and correlated with the Gates-GFR in the training group. From this correlation a formula was derived for single-kidney CT-GFR calculation, which was validated by a paired t test and linear regression analysis with the single-kidney Gates-GFR in the validation group.

Results

In the training group, the FRA (x-axis) correlated well (r = 0.95, p < 0.001) with single-kidney Gates-GFR (y-axis), producing a regression equation of y = 1665x + 1.5 for single-kidney CT-GFR calculation. In the validation group, the difference between the methods of single-kidney GFR measurements was 0.38 ± 5.57 mL/min (p = 0.471); the regression line is identical to the diagonal (intercept = 0 and slope = 1) (p = 0.727 and p = 0.473, respectively), with a standard deviation of residuals of 5.56 mL/min.

Conclusion

A convenient and rapid single-kidney CT-GFR technique was presented and validated in this investigation.

Key Points

• The new CT-GFR method takes about 2.5 min of patient time.
• The CT-GFR method demonstrated identical results to the Gates-GFR method.
• The CT-GFR method is based on the fractional renal accumulation of iodinated CM.
• The CT-GFR method is achieved without additional radiation dose to the patient.
Appendix
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Metadata
Title
Determination of glomerular filtration rate (GFR) from fractional renal accumulation of iodinated contrast material: a convenient and rapid single-kidney CT-GFR technique
Authors
XiaoDong Yuan
Wei Tang
WenWei Shi
Libao Yu
Jing Zhang
Qing Yuan
Shan You
Ning Wu
Guokun Ao
Tingting Ma
Publication date
01-07-2018
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 7/2018
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-017-5289-7

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