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01-06-2018 | Magnetic Resonance

Dynamic non-invasive ASL perfusion imaging of a normal pancreas with secretin augmented MR imaging

Authors: Khoschy Schawkat, Michael Ith, Andreas Christe, Wolfgang Kühn, Yojena Chittazhathu, Lauren Bains, Val Murray Runge, Johannes T. Heverhagen

Published in: European Radiology | Issue 6/2018

Abstract

Objectives

To investigate prospectively the repeatability of pancreatic perfusion measurements using arterial spin labelling (ASL) and to determine the increase in perfusion due to secretin stimulation.

Material and methods

An (FAIR)-TrueFISP ASL sequence was applied to determine the perfusion of the pancreatic head in a 3T MRI scanner. Ten healthy volunteers (four men, six women: mean age 28.5 ± 4.6 years; age range 25–40 years) were investigated twice within 1 week. The inter-individual variability was calculated using the standard deviation. Intra-individual agreement between the first and second scan was estimated using the Pearson correlation coefficient. A paired Wilcoxon rank-sum test was used to compare perfusion at baseline (BL) and during secretin stimulation.

Results

The mean BL perfusion of the pancreatic head was 285 ± 96 mL/100 g/min with an intra-individual correlation coefficient of 0.67 (strong) for repeated measurements. Secretin stimulation led to a significant increase (by 81%) in perfusion of the pancreatic head to 486 ±156 mL/100 g/min (p=0.002) with an intra-individual correlation of 0.29 (weak). A return to BL values was observed after 239 ± 92 s with a moderate intra-individual correlation coefficient of 0.42 for repeat measurements.

Conclusion

Dynamic non-invasive ASL imaging of the pancreas permitted quantification of pancreatic perfusion in a clinically applicable setting.

Key Points

• ASL imaging of the pancreas permitted quantification of pancreatic perfusion

• Secretin stimulation led to a significant increase in pancreatic perfusion

• The intra-individual correlation coefficient for baseline perfusion was strong for repeated measurements

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Title: Dynamic non-invasive ASL perfusion imaging of a normal pancreas with secretin augmented MR imaging
Authors: Khoschy Schawkat
Michael Ith
Andreas Christe
Wolfgang Kühn
Yojena Chittazhathu
Lauren Bains
Val Murray Runge
Johannes T. Heverhagen
Publication date: 01-06-2018
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 6/2018
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-017-5227-8

At a glance: The STEP trials

Springer Medicine

Dynamic non-invasive ASL perfusion imaging of a normal pancreas with secretin augmented MR imaging

Abstract

Objectives

Material and methods

Results

Conclusion

Key Points

At a glance: The STEP trials

Springer Medicine

Abstract

Objectives

Material and methods

Results

Conclusion

Key Points

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