Top

European Radiology

Published in:

01-04-2018 | Magnetic Resonance

Identification of intraplaque haemorrhage in carotid artery by simultaneous non-contrast angiography and intraPlaque haemorrhage (SNAP) imaging: a magnetic resonance vessel wall imaging study

Authors: Dongye Li, Huilin Zhao, Xiaoyi Chen, Shuo Chen, Huiyu Qiao, Le He, Rui Li, Jianrong Xu, Chun Yuan, Xihai Zhao

Published in: European Radiology | Issue 4/2018

Abstract

Objectives

To investigate the usefulness of Simultaneous Non-contrast Angiography and intraPlaque haemorrhage (SNAP) imaging in characterising carotid intraplaque haemorrhage (IPH) compared with magnetisation-prepared rapid acquisition gradient-echo (MP-RAGE) sequence.

Methods

Fifty-four symptomatic patients (mean age: 63.1 ± 5.7 years, 38 males) with carotid atherosclerosis were recruited and underwent carotid MR imaging. The presence and area of IPH on SNAP and MP-RAGE images were determined. The agreement in identifying IPH and its area between SNAP and MP-RAGE was analysed.

Results

Of 1368 slices with acceptable image quality in 54 patients, 13% and 22.6% were found to have IPH on MP-RAGE and SNAP images, respectively. There was moderate agreement between MP-RAGE and SNAP sequences in identifying IPH (κ = 0.511, p = 0.029). The area of IPH on SNAP images was significantly larger than that on MP-RAGE images (17.9 ± 18.2 mm² vs. 9.2 ± 10.5 mm², p < 0.001). For IPHs detected by SNAP imaging, the area of IPHs also detected by the MP-RAGE sequence was significantly larger than that of IPHs not detected by the MP-RAGE sequence (17.9 ± 19.2 mm² vs. 6.4 ± 6.2 mm², p < 0.001).

Conclusion

Compared with the MP-RAGE sequence, SNAP imaging detects more IPHs, particularly for smaller IPHs, suggesting that SNAP imaging might be a more sensitive tool for identification of carotid haemorrhagic plaques.

Key Points

• Moderate agreement was found between SNAP and MP-RAGE in identification of IPH

• SNAP imaging might be a more sensitive tool to detect carotid IPHs

• Compared with the MP-RAGE sequence, SNAP imaging can detect carotid IPHs with smaller size

• SNAP imaging can help clinicians to optimise the treatment strategy

Takaya N, Yuan C, Chu B et al (2005) Presence of intraplaque hemorrhage stimulates progression of carotid atherosclerotic plaques: a high-resolution magnetic resonance imaging study. Circulation 111:2768–2775CrossRefPubMed

Underhill HR, Yuan C, Yarnykh VL et al (2009) Arterial remodeling in the subclinical carotid artery disease. JACC Cardiovasc Imaging 2:1381–1389CrossRefPubMedPubMedCentral

WH X, Li ML, Gao S et al (2012) Middle cerebral artery intraplaque hemorrhage: prevalence and clinical relevance. Ann Neurol 71:195–198CrossRef

Singh N, Moody AR, Gladstone DJ et al (2009) Moderate carotid artery stenosis: MR imaging-depicted intraplaque hemorrhage predicts risk of cerebrovascular ischemic events in asymptomatic men. Radiology 252:502–508CrossRefPubMed

Altaf N, Daniels L, Morgan PS et al (2008) Detection of intraplaque hemorrhage by magnetic resonance imaging in symptomatic patients with mild to moderate carotid stenosis predicts recurrent neurological events. J Vasc Surg 47:337–342CrossRefPubMed

Takaya N, Yuan C, Chu B et al (2006) Association between carotid plaque characteristics and subsequent ischemic cerebrovascular events: a prospective assessment with MRI--initial results. Stroke 37:818–823CrossRefPubMed

Noguchi T, Yamada N, Higashi M et al (2011) High-intensity signals in carotid plaques on T1-weighted magnetic resonance imaging predict coronary events in patients with coronary artery disease. JACC Cardiovasc Imaging 58:416–422

Yamada K, Yoshimura S, Kawasaki M et al (2011) Embolic complications after carotid artery stenting or carotid endarterectomy are associated with tissue characteristics of carotid plaques evaluated by magnetic resonance imaging. Atherosclerosis 215:399–404CrossRefPubMed

Ota H, Yarnykh VL, Ferguson MS et al (2010) Carotid intraplaque hemorrhage imaging at 3.0-T MR imaging: comparison of the diagnostic performance of three T1-weighted sequences. Radiology 254:551–563CrossRefPubMedPubMedCentral

10.

Yao B, Yang L, Wang G et al (2016) Diffusion measurement of intraplaque hemorrhage and intramural hematoma using diffusion weighted MRI at 3T in cervical artery. Eur Radiol 26:3737–3743CrossRefPubMed

11.

Wang J, Börnert P, Zhao H et al (2013) Simultaneous non-contrast angiography and intraplaque hemorrhage (SNAP) imaging for carotid atherosclerotic disease evaluation. Magn Reson Med 69:337–345CrossRefPubMed

12.

Kerwin W, Xu D, Liu F et al (2007) Magnetic resonance imaging of carotid atherosclerosis: plaque analysis. Top Magn Reson imaging 18:371–378CrossRefPubMed

13.

Underhill HR, Yuan C, Terry JG et al (2008) Differences in carotid arterial morphology and composition between individuals with and without obstructive coronary artery disease: a cardiovascular magnetic resonance study. J Cardiovasc Magn Reson 10:1–11CrossRef

14.

Wang J, Ferguson MS, Balu N et al (2010) Improved carotid intraplaque hemorrhage imaging using a slab-selective phase-sensitive inversion-recovery (SPI) sequence. Magn Reson Med 64:1332–1340CrossRefPubMed

15.

Liu J, Balu N, Hippe DS et al (2016) Semi-automatic carotid intraplaque hemorrhage detection and quantification on magnetization-prepared rapid acquisition gradient-echo (MP-RAGE) with optimized threshold selection. J Cardiovasc Magn Reson 18:41CrossRefPubMedPubMedCentral

16.

Li Q, Wang J, Chen H et al (2015) Characterization of craniocervical artery dissection by simultaneous MR noncontrast angiography and intraplaque hemorrhage imaging at 3T. AJNR Am J Neuroradiol 36:1769–1775CrossRefPubMed

17.

Wang J, Guan M, Yamada K et al (2016) In vivo validation of simultaneous non- contrast angiography and intraPlaque hemorrhage (SNAP) magnetic resonance angiography: An intracranial artery study. Plos One 11:e0149130CrossRefPubMedPubMedCentral

Title: Identification of intraplaque haemorrhage in carotid artery by simultaneous non-contrast angiography and intraPlaque haemorrhage (SNAP) imaging: a magnetic resonance vessel wall imaging study
Authors: Dongye Li
Huilin Zhao
Xiaoyi Chen
Shuo Chen
Huiyu Qiao
Le He
Rui Li
Jianrong Xu
Chun Yuan
Xihai Zhao
Publication date: 01-04-2018
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 4/2018
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-017-5096-1

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Identification of intraplaque haemorrhage in carotid artery by simultaneous non-contrast angiography and intraPlaque haemorrhage (SNAP) imaging: a magnetic resonance vessel wall imaging study

Abstract

Objectives

Methods

Results

Conclusion

Key Points

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusion

Key Points

Please log in to get access to this content

Other articles of this Issue 4/2018

The impact of MRI sequence on tumour staging and gross tumour volume delineation in squamous cell carcinoma of the anal canal

Extracellular contrast agent-enhanced MRI: 15-min delayed phase may improve the diagnostic performance for hepatocellular carcinoma in patients with chronic liver disease

Characterisation of fibrosis in chemically-induced rat mammary carcinomas using multi-modal endogenous contrast MRI on a 1.5T clinical platform

Gadolinium retention after administration of contrast agents based on linear chelators and the recommendations of the European Medicines Agency

Detection of lung carcinoma with predominant ground-glass opacity on CT using temporal subtraction method

Medial temporal lobe atrophy ratings in a large 75-year-old population-based cohort: gender-corrected and education-corrected normative data