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European Radiology
Published in: European Radiology 2/2018

01-02-2018 | Contrast Media

Gadoxetate disodium-induced tachypnoea and the effect of dilution method: a proof-of-concept study in mice

Authors: Hiroyuki Akai, Koichiro Yasaka, Masanori Nojima, Akira Kunimatsu, Yusuke Inoue, Osamu Abe, Kuni Ohtomo, Shigeru Kiryu

Published in: European Radiology | Issue 2/2018

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Abstract

Objectives

To directly investigate the rapid respiratory effect of gadoxetate disodium in an experimental study using mice.

Methods

After confirming the steady respiratory state under general anaesthesia, eight mice were injected with all test agents in the following order: phosphate-buffered saline (A, control group), 1.25 mmol/kg of gadoteridol (B) or gadopentetate dimeglumine (C), or 0.31 mmol/kg of gadoxetate disodium (D, E). The experimenter was not blinded to the agents. The injection dose was fixed as 100 μL for Groups A-D and 50 μL for Group E. We continuously monitored and recorded respiratory rate (RR), peripheral oxygen saturation (SpO2), and heart rate. The time-series changes from 0 to 30 s were compared by the linear mixed method

Results

Groups D and E showed the largest RR increase (20.6 and 20.3 breaths/min, respectively) and were significantly larger compared to Group A (3.36 breaths/min, both P<0.001). RR change of Groups D and E did not differ. RR change of Groups B and C was smaller (0.72 and 12.4 breaths/min, respectively) and did not differ statistically with Group A. Significant bradycardia was observed only in Group C (P<0.001). SpO2 was constant in all groups.

Conclusions

Gadoxetate disodium causes a rapid tachypnoea without significant change of SpO2 and heart rate regardless of the dilution method.

Key Points

• Injection of gadoxetate disodium causes tachypnoea.
• Dilution method did not alter the rapid respiratory effect of gadoxetate disodium.
• The respiratory effect of gadoxetate disodium was larger than other contrast agents.
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Metadata
Title
Gadoxetate disodium-induced tachypnoea and the effect of dilution method: a proof-of-concept study in mice
Authors
Hiroyuki Akai
Koichiro Yasaka
Masanori Nojima
Akira Kunimatsu
Yusuke Inoue
Osamu Abe
Kuni Ohtomo
Shigeru Kiryu
Publication date
01-02-2018
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 2/2018
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-017-5037-z

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