Published in:
01-12-2017 | Breast
Accuracy and reading time for six strategies using digital breast tomosynthesis in women with mammographically negative dense breasts
Published in: European Radiology | Issue 12/2017
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Objective
To compare six strategies using digital breast tomosynthesis in women with mammographically negative dense breasts.
Materials and methods
This is a substudy of the ‘ASTOUND’ trial. 163 women who underwent tomosynthesis with synthetically reconstructed projection images (S-2D) inclusive of 13 (7.9%) cases diagnosed with breast cancer at histopathology after surgery were evaluated. Accuracy measures and screen-reading time of six reading strategies were assessed: (A) Single reading of S-2D alone, (B) single reading of tomosynthesis alone, (C) single reading of joint interpretation of tomosynthesis + S-2D, (D) double-reading of S-2D alone, (E) double reading of tomosynthesis alone, (F) double reading of joint interpretation of tomosynthesis + S-2D.
Results
The median age of the patients was 53 years (range, 36–88 years). The highest global accuracy was obtained with double reading of tomosynthesis + S2D (F) with an AUC of 0.979 (p<0.001) and a mean reading time of 154 s versus 34 s for the fastest strategy (single reading of S-2D alone). The AUCs for the other five strategies did not differ from each other.
Conclusion
Double reading of tomosynthesis+ S2D had the best accuracy of six screen-reading strategies although it had the longest reading time.
Key Points
• Tomosynthesis acquisitions are progressively implemented with reconstructed synthesized 2D images
• Double reading using S-2D plus tomosynthesis had the highest global accuracy (p<0.001).
• Double reading of S-2D plus tomosynthesis increased reading time.