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European Radiology
Published in: European Radiology 11/2017

01-11-2017 | Oncology

Evaluation of renal cell carcinoma histological subtype and fuhrman grade using 18F-fluorodeoxyglucose-positron emission tomography/computed tomography

Authors: Reiko Nakajima, Sayumi Nozaki, Tsunenori Kondo, Yoji Nagashima, Koichiro Abe, Shuji Sakai

Published in: European Radiology | Issue 11/2017

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Abstract

Objectives

We evaluated 18F-fluorodeoxyglucose (FDG) uptake by renal cell carcinomas (RCCs) to determine whether different histological subtypes and Fuhrman grades can be distinguished.

Methods

We retrospectively reviewed the records and maximum standardised uptake value (SUVmax) of 147 patients with 154 RCCs who underwent FDG-positron emission tomography (PET)/computed tomography (CT) prior to tumour resection.

Results

The SUVmax was significantly lower in chromophobe RCC (chRCC) tumours than in clear cell RCC (ccRCC; p = 0.003) and papillary RCC (pRCC; p = 0.034) tumours. The mean tumour SUVmax was 4.58 ± 4.1 (range, 1.29–30.4) for ccRCC, 3.98 ± 1.9 (range, 0.49–6.72) for pRCC, and 1.93 ± 0.9 (range, 0.89–3.41) for chRCC. The SUVmax was not significantly different between the ccRCC and pRCC groups. In ccRCC and pRCC tumours, high-grade tumours had a significantly greater SUVmax (p < 0.001 and p < 0.05) than low-grade tumours by analysis of variance (ANOVA) and the Mann-Whitney U test. In ccRCC, multivariate regression analysis indicated that the SUVmax was a significant indicator of Fuhrman grade. No significant differences in uptake were observed between high- and low-grade chRCC tumours.

Conclusions

The SUVmax obtained using FDG-PET/CT may be an important indicator for predicting tumour grade in ccRCC and pRCC.

Key Points

• FDG accumulation reflects tumour aggressiveness and correlates with Fuhrman grade.
• FDG-PET/CT enables the differentiation of high- and low-grade ccRCC and pRCCs.
• FDG-PET/CT may valuable in the identification of some high-grade RCCs.
Literature
1.
Hoekstra CJ, Stroobants SG, Hoekstra OS et al (2003) The value of [18F] fluoro-2-deoxy-D glucose positron emission tomography in the selection of patients with stage IIIA-N2 non- small cell lung cancer for combined modality treatment. Lung Cancer 39:151–157CrossRef
2.
Takahashi M, Kume H, Koyama K et al (2015) Preoperative evaluation of renal cell carcinoma by using 18F-FDG-PET/CT. Clin Nucl Med 40:936–940CrossRef
3.
Aide N, Cappele O, Bottet P et al (2003) Efficiency of [18F]FDG PET in characterising renal cancer and detecting distant metastases: a comparison with CT. Eur J Nucl Med Mol Imaging 30:1236–1245CrossRef
4.
Ozülker T, Ozülker F, Ozbek E, Ozpaçaci T (2011) A prospective diagnostic accuracy study of F-18 fluorodeoxyglucose-positron emission tomography/computed tomography in the evaluation of indeterminate renal masses. Nucl Med Commun 32:265–272CrossRef
5.
Noda Y, Kanematsu M, Goshima S et al (2015) 18-F fluorodeoxyglucose uptake in positron emission tomography as a pathological grade predictor for renal clear cell carcinomas. Eur Radiol 25:3009–3016CrossRef
6.
Polat EC, Otunctemur A, Ozbek E et al (2014) Standardized uptake values highly correlate with tumour size and Fuhrman grade in patients with clear cell renal cell carcinoma. Asian Pac J Cancer Prev 15:7821–7824CrossRef
7.
Reuter VE (2006) The pathology of renal epithelial neoplasms. Semin Oncol 33:534–543CrossRef
8.
Cheville JC, Lohse CM, Zincke H, Weaver AL, Blute ML (2003) Comparisons of outcome and prognostic features among histologic subtypes of renal cell carcinoma. Am J Surg Pathol 27:612–624CrossRef
9.
Hoffmann NE, Gillett MD, Cheville JC, Lohse CM, Leibovich BC, Blute ML (2008) Differences in organ system of distant metastasis by renal cell carcinoma subtype. J Urol 179:474–477CrossRef
10.
Zisman A, Pantuck AJ, Dorey F et al (2001) Improved prognostication of renal cell carcinoma using an integrated staging system. J Clin Oncol 19:1649–1657CrossRef
11.
Fuhrman SA, Lasky LC, Limas C (1982) Prognostic significance of morphologic parameters in renal cell carcinoma. Am J Surg Pathol 6:655–663CrossRef
12.
Delahunt B, Bethwaite PB, Nacey JN (2007) Outcome prediction for renal cell carcinoma: evaluation of prognostic factors for tumours divided according to histological subtype. Pathology 39:459–465CrossRef
13.
Shuin T, Kondo K, Torigoe S et al (1994) Frequent somatic mutations and loss of heterozygosity of the von Hippel-Lindau tumour suppressor gene in primary human renal cell carcinomas. Cancer Res 54:2852–2855PubMed
14.
Kondo K, Yao M, Yoshida M et al (2002) Comprehensive mutational analysis of the VHL gene in sporadic renal cell carcinoma: relationship to clinicopathological parameters. Genes Chromosom Cancer 34:58–68CrossRef
15.
Kim WY, Kaelin WG (2004) Role of VHL gene mutation in human cancer. J Clin Oncol 22:4991–5004CrossRef
16.
Gossage L, Eisen T (2010) Alterations in VHL as potential biomarkers in renal-cell carcinoma. Nat Rev Clin Oncol 7:277–288CrossRef
17.
Maxwell PH, Wiesener MS, Chang GW et al (1999) The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399:271–275CrossRef
18.
Nagashima Y, Kuroda N, Yao N (2013) Transition of organizational category on renal cancer. Jpn J Clin Oncol 43:233–242CrossRef
19.
Miyakita H, Tokunaga M, Onda H et al (2002) Significance of 18 F-fluorodeoxyglucose positron emission tomography (FDG-PET) for detection of renal cell carcinoma and immunohistochemical glucose transporter 1 (GLUT-1) expression in the cancer. Int J Urol 9:15–18CrossRef
20.
Maruyama M, Yoshizako T, Uchida K et al (2015) Comparison of utility of tumour size and apparent diffusion coefficient for differentiation of low- and high-grade clear-cell renal cell carcinoma. Acta Radiol 56:250–256CrossRef
21.
Cornelis F, Tricaud E, Lasserre AS et al (2015) Multiparametric magnetic resonance imaging for the differentiation of low and high grade clear cell renal carcinoma. Eur Radiol 25:24–31CrossRef
22.
Alam NA, Rowan AJ, Wortham NC et al (2003) Genetic and functional analyses of FH mutations in multiple cutaneous and uterine leiomyomatosis, hereditary leiomyomatosis and renal cancer, and fumarate hydratase deficiency. Hum Mol Genet 12:1241–1252CrossRef
23.
Isaacs JS, Jung YJ, Mole DR et al (2005) HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability. Cancer Cell 8:143–153CrossRef
24.
Young JR, Margolis D, Sauk S, Pantuck AJ, Sayre J, Raman SS (2013) Clear cell renal cell carcinoma: discrimination from other renal cell carcinoma subtypes and oncocytoma at multiphasic multidetector CT. Radiology 267:444–453CrossRef
25.
Jinzaki M, Tanimoto A, Mukai M et al (2002) Double-phase helical CT of small renal parenchymal neoplasms: correlation with pathologic findings and tumour angiogenesis. J Comput Assist Tomogr 24:835–842CrossRef
26.
Delahunt B, Sika-Paotonu D, Bethwaite PB et al (2007) Fuhrman grading is not appropriate for chromophobe renal cell carcinoma. Am J Surg Pathol 31:957–960CrossRef
Metadata
Title
Evaluation of renal cell carcinoma histological subtype and fuhrman grade using 18F-fluorodeoxyglucose-positron emission tomography/computed tomography
Authors
Reiko Nakajima
Sayumi Nozaki
Tsunenori Kondo
Yoji Nagashima
Koichiro Abe
Shuji Sakai
Publication date
01-11-2017
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 11/2017
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-017-4875-z

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