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European Radiology
Published in: European Radiology 6/2017

Open Access 01-06-2017 | Magnetic Resonance

“Textural analysis of multiparametric MRI detects transition zone prostate cancer”

Authors: Harbir S. Sidhu, Salvatore Benigno, Balaji Ganeshan, Nikos Dikaios, Edward W. Johnston, Clare Allen, Alex Kirkham, Ashley M. Groves, Hashim U. Ahmed, Mark Emberton, Stuart A. Taylor, Steve Halligan, Shonit Punwani

Published in: European Radiology | Issue 6/2017

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Abstract

Objectives

To evaluate multiparametric-MRI (mpMRI) derived histogram textural-analysis parameters for detection of transition zone (TZ) prostatic tumour.

Methods

Sixty-seven consecutive men with suspected prostate cancer underwent 1.5T mpMRI prior to template-mapping-biopsy (TPM). Twenty-six men had ‘significant’ TZ tumour. Two radiologists in consensus matched TPM to the single axial slice best depicting tumour, or largest TZ diameter for those with benign histology, to define single-slice whole TZ-regions-of-interest (ROIs). Textural-parameter differences between single-slice whole TZ-ROI containing significant tumour versus benign/insignificant tumour were analysed using Mann Whitney U test. Diagnostic accuracy was assessed by receiver operating characteristic area under curve (ROC-AUC) analysis cross-validated with leave-one-out (LOO) analysis.

Results

ADC kurtosis was significantly lower (p < 0.001) in TZ containing significant tumour with ROC-AUC 0.80 (LOO-AUC 0.78); the difference became non-significant following exclusion of significant tumour from single-slice whole TZ-ROI (p = 0.23). T1-entropy was significantly lower (p = 0.004) in TZ containing significant tumour with ROC-AUC 0.70 (LOO-AUC 0.66) and was unaffected by excluding significant tumour from TZ-ROI (p = 0.004). Combining these parameters yielded ROC-AUC 0.86 (LOO-AUC 0.83).

Conclusion

Textural features of the whole prostate TZ can discriminate significant prostatic cancer through reduced kurtosis of the ADC-histogram where significant tumour is included in TZ-ROI and reduced T1 entropy independent of tumour inclusion.

Key Points

• MR textural features of prostate transition zone may discriminate significant prostatic cancer.
• Transition zone (TZ) containing significant tumour demonstrates a less peaked ADC histogram.
• TZ containing significant tumour reveals higher post-contrast T1-weighted homogeneity.
• The utility of MR texture analysis in prostate cancer merits further investigation.
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Metadata
Title
“Textural analysis of multiparametric MRI detects transition zone prostate cancer”
Authors
Harbir S. Sidhu
Salvatore Benigno
Balaji Ganeshan
Nikos Dikaios
Edward W. Johnston
Clare Allen
Alex Kirkham
Ashley M. Groves
Hashim U. Ahmed
Mark Emberton
Stuart A. Taylor
Steve Halligan
Shonit Punwani
Publication date
01-06-2017
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 6/2017
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-016-4579-9

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