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01-05-2017 | Breast

Diffusion-weighted imaging of breast lesions: Region-of-interest placement and different ADC parameters influence apparent diffusion coefficient values

Authors: Hubert Bickel, Katja Pinker, Stephan Polanec, Heinrich Magometschnigg, Georg Wengert, Claudio Spick, Wolfgang Bogner, Zsuzsanna Bago-Horvath, Thomas H. Helbich, Pascal Baltzer

Published in: European Radiology | Issue 5/2017

Abstract

Objectives

To investigate the influence of region-of-interest (ROI) placement and different apparent diffusion coefficient (ADC) parameters on ADC values, diagnostic performance, reproducibility and measurement time in breast tumours.

Methods

In this IRB-approved, retrospective study, 149 histopathologically proven breast tumours (109 malignant, 40 benign) in 147 women (mean age 53.2) were investigated. Three radiologists independently measured minimum, mean and maximum ADC, each using three ROI placement approaches:1 – small 2D-ROI, 2 – large 2D-ROI and 3 – 3D-ROI covering the whole lesion. One reader performed all measurements twice. Median ADC values, diagnostic performance, reproducibility, and measurement time were calculated and compared between all combinations of ROI placement approaches and ADC parameters.

Results

Median ADC values differed significantly between the ROI placement approaches (p < .001). Minimum ADC showed the best diagnostic performance (AUC .928–.956), followed by mean ADC obtained from 2D ROIs (.926–.94). Minimum and mean ADC showed high intra- (ICC .85–.94) and inter-reader reproducibility (ICC .74–.94). Median measurement time was significantly shorter for the 2D ROIs (p < .001).

Conclusions

ROI placement significantly influences ADC values measured in breast tumours. Minimum and mean ADC acquired from 2D-ROIs are useful for the differentiation of benign and malignant breast lesions, and are highly reproducible, with rapid measurement.

Key Points

• Region of interest placement significantly influences apparent diffusion coefficient of breast tumours.

• Minimum and mean apparent diffusion coefficient perform best and are reproducible.

• 2D regions of interest perform best and provide rapid measurement times.

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Title: Diffusion-weighted imaging of breast lesions: Region-of-interest placement and different ADC parameters influence apparent diffusion coefficient values
Authors: Hubert Bickel
Katja Pinker
Stephan Polanec
Heinrich Magometschnigg
Georg Wengert
Claudio Spick
Wolfgang Bogner
Zsuzsanna Bago-Horvath
Thomas H. Helbich
Pascal Baltzer
Publication date: 01-05-2017
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 5/2017
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-016-4564-3

At a glance: The STEP trials

Springer Medicine

Diffusion-weighted imaging of breast lesions: Region-of-interest placement and different ADC parameters influence apparent diffusion coefficient values

Abstract

Objectives

Methods

Results

Conclusions

Key Points

At a glance: The STEP trials

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

Key Points

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