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European Radiology
Published in: European Radiology 5/2017

01-05-2017 | Magnetic Resonance

Osteonecrosis detected by whole body magnetic resonance in patients with Hodgkin Lymphoma treated by BEACOPP

Authors: Domenico Albano, Caterina Patti, Ludovico La Grutta, Emanuele Grassedonio, Antonino Mulè, Giuseppe Brancatelli, Roberto Lagalla, Massimo Midiri, Massimo Galia

Published in: European Radiology | Issue 5/2017

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Abstract

Objectives

The purpose of our retrospective review of prospectively acquired Whole Body Magnetic Resonance (WB-MRI) scans was to assess the incidence of osteonecrosis in patients who received different chemotherapies.

Methods

We evaluated the WB-MRI scans performed on 42 patients with Hodgkin Lymphoma treated by three chemotherapy regimens (6ABVD, 2ABVD + 4BEACOPP, 2ABVD + 8BEACOPP), excluding patients with the main risk factors for osteonecrosis.

Results

Six out of seven patients (86 %) who received eight BEACOPP and one out of five patients (20 %) treated by four BEACOPP presented osteonecrosis, with a statistically significant difference of frequency between the two groups of patients (p < 0.05); no injury has been reported in patients treated by only ABVD. Among a total of 48 osteonecrotic lesions observed, 48 % were detected in the knee; multifocal osteonecrosis were detected in six out of seven patients (86 %).

Conclusions

The development of osteonecrosis is strictly related to the chemotherapy protocol adopted and the number of cycles received, with a strong correlation between the dose of corticosteroids included in the BEACOPP scheme and this complication. WB-MRI can be considered as a helpful tool that allows detecting earlier osteonecrotic lesions in patients treated with corticosteroids.

Key Points

• Osteonecrosis is a possible complication of patients with Lymphoma treated by chemotherapy.
• Osteonecrosis is related to the corticosteroids included within the BEACOPP protocol.
• WB-MRI allows detecting osteonecrotic lesions in patients treated with corticosteroids.
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Metadata
Title
Osteonecrosis detected by whole body magnetic resonance in patients with Hodgkin Lymphoma treated by BEACOPP
Authors
Domenico Albano
Caterina Patti
Ludovico La Grutta
Emanuele Grassedonio
Antonino Mulè
Giuseppe Brancatelli
Roberto Lagalla
Massimo Midiri
Massimo Galia
Publication date
01-05-2017
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 5/2017
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-016-4535-8

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