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European Radiology
Published in: European Radiology 3/2016

Open Access 01-03-2016 | Contrast Media

What Evidence Is There That Gadobutrol Causes Increasing Signal Intensity within the Dentate Nucleus and Globus Pallidus on Unenhanced T1W MRI in Patients with RRMS?

Authors: Jacob Agris, Hubertus Pietsch, Thomas Balzer

Published in: European Radiology | Issue 3/2016

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Key Points

• The study by Stojanov et al does not convincingly support the conclusion that gadobutrol causes higher T1 enhancement in brain on unenhanced MRI
• The study by Stojanov et al does not rule out confounding factors
• The study by Stojanov et al has limitations in study design
Literature
1.
Stojanov DA, Aracki-Trenkic A, Vojinovic S, Benedeto-Stojanov D, Ljubisavljevic S. Increasing signal intensity within the dentate nucleus and globus pallidus on unenhanced T1W magnetic resonance images in patients with relapsing-remitting multiple sclerosis: correlation with cumulative dose of a macrocyclic gadolinium-based contrast agent, gadobutrol. Eur Radiol. 2015 Jun 25.
2.
Roccatagliata L, Vuolo L, Bonzano L, Pichiecchio A, Mancardi GL (2009) Multiple sclerosis: hyperintense dentate nucleus on unenhanced T1-weighted MR images is associated with the secondary progressive subtype. Radiology 251(2):503–10CrossRefPubMed
3.
Craelius W, Migdal MW, Luessenhop CP, Sugar A, Mihalakis I (1982) Iron deposits surrounding multiple sclerosis plaques. Arch Pathol Lab Med 106(8):397–9PubMed
4.
McDonald RJ, McDonald JS, Kallmes DF, Jentoft ME, Murray DL, Thielen KR et al (2015) Intracranial Gadolinium Deposition after Contrast-enhanced MR Imaging. Radiology 275(3):772–82CrossRefPubMed
Metadata
Title
What Evidence Is There That Gadobutrol Causes Increasing Signal Intensity within the Dentate Nucleus and Globus Pallidus on Unenhanced T1W MRI in Patients with RRMS?
Authors
Jacob Agris
Hubertus Pietsch
Thomas Balzer
Publication date
01-03-2016
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 3/2016
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-015-4019-2

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