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01-07-2015 | Computed Tomography

Sub-milliSievert (sub-mSv) CT colonography: a prospective comparison of image quality and polyp conspicuity at reduced-dose versus standard-dose imaging

Authors: Meghan G. Lubner, B. Dustin Pooler, Douglas R. Kitchin, Jie Tang, Ke Li, David H. Kim, Alejandro Munoz del Rio, Guang-Hong Chen, Perry J. Pickhardt

Published in: European Radiology | Issue 7/2015

Abstract

Objective

To prospectively compare reduced-dose (RD) CT colonography (CTC) with standard-dose (SD) imaging using several reconstruction algorithms.

Methods

Following SD supine CTC, 40 patients (mean age, 57.3 years; 17 M/23 F; mean BMI, 27.2) underwent an additional RD supine examination (targeted dose reduction, 70–90 %). DLP, CTDI_vol, effective dose, and SSDE were compared. Several reconstruction algorithms were applied to RD series. SD-FBP served as reference standard. Objective image noise, subjective image quality and polyp conspicuity were assessed.

Results

Mean CTDI_vol and effective dose for RD series was 0.89 mGy (median 0.65) and 0.6 mSv (median 0.44), compared with 3.8 mGy (median 3.1) and 2.8 mSv (median 2.3) for SD series, respectively. Mean dose reduction was 78 %. Mean image noise was significantly reduced on RD-PICCS (24.3 ± 19HU) and RD-MBIR (19 ± 18HU) compared with RD-FBP (90 ± 33), RD-ASIR (72 ± 27) and SD-FBP (47 ± 14 HU). 2D image quality score was higher with RD-PICCS, RD-MBIR, and SD-FBP (2.7 ± 0.4/2.8 ± 0.4/2.9 ± 0.6) compared with RD-FBP (1.5 ± 0.4) and RD-ASIR (1.8 ± 0.44). A similar trend was seen with 3D image quality scores. Polyp conspicuity scores were similar between SD-FBP/RD-PICCS/RD-MBIR (3.5 ± 0.6/3.2 ± 0.8/3.3 ± 0.6).

Conclusion

Sub-milliSievert CTC performed with iterative reconstruction techniques demonstrate decreased image quality compared to SD, but improved image quality compared to RD images reconstructed with FBP.

Key points

• CT colonography dose can be substantially lowered using advanced iterative reconstruction techniques.

• Iterative reconstruction techniques (MBIR/PICCS) reduce image noise and improve image quality.

• The PICCS/MBIR-reconstructed, reduced-dose series shows decreased 2D/3D image quality compared to the standard-dose series.

• Polyp conspicuity was similar on standard-dose images compared to reduced-dose images reconstructed with MBIR/PICCS.

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Title: Sub-milliSievert (sub-mSv) CT colonography: a prospective comparison of image quality and polyp conspicuity at reduced-dose versus standard-dose imaging
Authors: Meghan G. Lubner
B. Dustin Pooler
Douglas R. Kitchin
Jie Tang
Ke Li
David H. Kim
Alejandro Munoz del Rio
Guang-Hong Chen
Perry J. Pickhardt
Publication date: 01-07-2015
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 7/2015
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-015-3603-9

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Sub-milliSievert (sub-mSv) CT colonography: a prospective comparison of image quality and polyp conspicuity at reduced-dose versus standard-dose imaging

Abstract

Objective

Methods

Results

Conclusion

Key points

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Objective

Methods

Results

Conclusion

Key points

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