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European Radiology
Published in: European Radiology 5/2015

01-05-2015 | Gastrointestinal

Automated two-point dixon screening for the evaluation of hepatic steatosis and siderosis: comparison with R2*-relaxometry and chemical shift-based sequences

Authors: B. Henninger, H. Zoller, S. Rauch, M. Schocke, S. Kannengiesser, X. Zhong, G. Reiter, W. Jaschke, C. Kremser

Published in: European Radiology | Issue 5/2015

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Abstract

Objectives

To evaluate the automated two-point Dixon screening sequence for the detection and estimated quantification of hepatic iron and fat compared with standard sequences as a reference.

Methods

One hundred and two patients with suspected diffuse liver disease were included in this prospective study. The following MRI protocol was used: 3D-T1-weighted opposed- and in-phase gradient echo with two-point Dixon reconstruction and dual-ratio signal discrimination algorithm (“screening” sequence); fat-saturated, multi-gradient-echo sequence with 12 echoes; gradient-echo T1 FLASH opposed- and in-phase. Bland–Altman plots were generated and correlation coefficients were calculated to compare the sequences.

Results

The screening sequence diagnosed fat in 33, iron in 35 and a combination of both in 4 patients. Correlation between R2* values of the screening sequence and the standard relaxometry was excellent (r = 0.988). A slightly lower correlation (r = 0.978) was found between the fat fraction of the screening sequence and the standard sequence. Bland–Altman revealed systematically lower R2* values obtained from the screening sequence and higher fat fraction values obtained with the standard sequence with a rather high variability in agreement.

Conclusions

The screening sequence is a promising method with fast diagnosis of the predominant liver disease. It is capable of estimating the amount of hepatic fat and iron comparable to standard methods.

Key points

• MRI plays a major role in the clarification of diffuse liver disease.
• The screening sequence was introduced for the assessment of diffuse liver disease.
• It is a fast and automated algorithm for the evaluation of hepatic iron and fat.
• It is capable of estimating the amount of hepatic fat and iron.
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Metadata
Title
Automated two-point dixon screening for the evaluation of hepatic steatosis and siderosis: comparison with R2*-relaxometry and chemical shift-based sequences
Authors
B. Henninger
H. Zoller
S. Rauch
M. Schocke
S. Kannengiesser
X. Zhong
G. Reiter
W. Jaschke
C. Kremser
Publication date
01-05-2015
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 5/2015
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-014-3528-8

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