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01-02-2015 | Chest

Lung MRI of invasive fungal infection at 3 Tesla: evaluation of five different pulse sequences and comparison with multidetector computed tomography (MDCT)

Authors: Chenggong Yan, Xiangliang Tan, Qi Wei, Ru Feng, Caixia Li, Yuankui Wu, Peng Hao, Queenie Chan, Wei Xiong, Jun Xu, Yikai Xu

Published in: European Radiology | Issue 2/2015

Abstract

Objectives

To evaluate the diagnostic performance of five MR sequences to detect pulmonary infectious lesions in patients with invasive fungal infection (IFI), using multidetector computed tomography (MDCT) as the reference standard.

Methods

Thirty-four immunocompromised patients with suspected IFI underwent MDCT and MRI. The MR studies were performed using five pulse sequences at 3.0 T: T2-weighted turbo spin echo (TSE), short-tau inversion recovery (STIR), spectrally selective attenuated inversion recovery (SPAIR), T1-weighted high resolution isotropic volume excitation (e-THRIVE) and T1-weighted fast field echo (T1-FFE). The size, lesion-to-lung contrast ratio and the detectability of pulmonary lesions on MR images were assessed. Image quality and artefacts on different sequences were also rated.

Results

A total of 84 lesions including nodules (n = 44) and consolidation (n = 40) were present in 75 lobes. SPAIR and e-THRIVE images achieved high overall lesion-related sensitivities for the detection of pulmonary abnormalities (90.5 % and 86.9 %, respectively). STIR showed the highest lesion-to-lung contrast ratio for nodules (21.8) and consolidation (17.0), whereas TSE had the fewest physiological artefacts.

Conclusions

MRI at 3.0 T can depict clinically significant pulmonary IFI abnormalities with high accuracy compared to MDCT. SPAIR and e-THRIVE are preferred sequences for the detection of infectious lesions of 5 mm and larger.

Key Points

• A radiation-free radiological method is desirable for assessing pulmonary infectious lesions

• MRI at 3 T can depict lung infiltrates with good concordance to MDCT

• SPAIR and e-THRIVE are favourable sequences for the detection of pulmonary lesions

• The greatest benefit is for the diagnosis of lesions larger than 5 mm

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Title: Lung MRI of invasive fungal infection at 3 Tesla: evaluation of five different pulse sequences and comparison with multidetector computed tomography (MDCT)
Authors: Chenggong Yan
Xiangliang Tan
Qi Wei
Ru Feng
Caixia Li
Yuankui Wu
Peng Hao
Queenie Chan
Wei Xiong
Jun Xu
Yikai Xu
Publication date: 01-02-2015
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 2/2015
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-014-3432-2

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Lung MRI of invasive fungal infection at 3 Tesla: evaluation of five different pulse sequences and comparison with multidetector computed tomography (MDCT)

Abstract

Objectives

Methods

Results

Conclusions

Key Points

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

Key Points

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