Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
European Radiology
Published in: European Radiology 7/2013

01-07-2013 | Interventional

Percutaneous radiofrequency ablation of small renal tumours in patients with a single functioning kidney: long-term results

Authors: Miltiadis Krokidis, Stavros Spiliopoulos, Magdalena Jarzabek, Nikos Fotiadis, Tarun Sabharwal, Tim O’Brien, Andy Adam

Published in: European Radiology | Issue 7/2013

Login to get access

Abstract

Objectives

To evaluate the long-term results of percutaneous radiofrequency ablation (RFA) of small renal tumours in patients with a single functioning kidney (SFK).

Methods

This is a single-centre prospective study. Patients with an SFK and a tumour smaller than 3.5 cm, treated with RFA over a 7.5-year period, were included. Nineteen consecutive patients (12 male), aged between 33 and 83 years (mean 61.4), were treated for 23 lesions. Primary endpoints were technical success and tumour recurrence rate. Secondary endpoints were the deterioration of renal function and overall survival rate.

Results

The mean follow-up was 56.1 months (range 36–102). Primary technical success was 100 %. There were no major peri-procedural complications. In two cases, minor complications occurred. There was no significant difference between the baseline glomerular filtration rate (GFR) and GFR at 3, 12 and 24 months post-procedure. In four lesions (17 %), recurrence was detected and an additional RFA session was performed. None of the patients developed renal failure during their lifetime. Three of the patients died because of other reasons.

Conclusions

Percutaneous RFA of small renal tumours in patients with an SFK offers very satisfactory long-term results regarding preservation of renal function, local tumour control and overall survival.

Key Points

• Tumour in a single functioning kidney requires minimally invasive treatment.
• Radiofrequency ablation plays an established role in managing small renal tumours.
• Long-term results of radiofrequency ablation have shown satisfactory local tumour control.
• Long-term results have also shown that renal function may be preserved.
Literature
1.
2.
Hoffmann RT, Jakobs TF, Kubisch CH et al (2007) Renal cell carcinoma in patients with a solitary kidney after nephrectomy treated with radiofrequency ablation: mid term results. Eur J Radiol 73:652–656CrossRef
3.
Uzzo RG, Novick AC (2001) Nephron sparing surgery for renal tumors: indications, techniques and outcomes. J Urol 166:6–18PubMedCrossRef
4.
Miller DC, Schonlau M, Litwin MS, Lai J, Saigal CS, Urologic Diseases in America Project (2008) Renal and cardiovascular morbidity after partial or radical nephrectomy. Cancer 112:511–520PubMedCrossRef
5.
Sabharwal R, Vladica P (2006) Renal tumors: technical success and early clinical experience with radiofrequency ablation of 18 tumors. Cardiovasc Interv Radiol 29:202–209CrossRef
6.
Gervais DA, Arellano RS, Mueller PR (2005) Percutaneous radiofrequency ablation of renal cell carcinoma. Radiology 15:960–967
7.
Zlotta AR, Wildschutz T, Raviv G et al (1997) Radiofrequency interstitial tumor ablation (RITA) is a possible new modality for treatment of renal cancer: ex vivo and in vivo experience. J Endourol 11:251–2581PubMedCrossRef
8.
Farrell MA, Charboneau WJ, DiMarco DS et al (2003) Imaging-guided radiofrequency ablation of solid renal tumors. AJR Am J Roentgenol 180:1509–1513PubMedCrossRef
9.
Mylona S, Kokkinaki A, Pomoni M, Galani P, Ntai S, Thanos L (2008) Percutaneous radiofrequency ablation of renal cell carcinomas in patients with solitary kidney: 6 years experience. Eur J Radiol 69:351–356PubMedCrossRef
10.
Silverman SG, Lee BY, Seltzer SE, Bloom DA, Corless CL, Adams DF (1994) Small (<3 cm) renal masses: correlation of spiral CT features and pathologic findings. AJR Am J Roentgenol 163:597–605PubMedCrossRef
11.
Therasse P, Arbuck SG, Eisenhauer EA et al (2000) New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J Natl Cancer Inst 92:205–216PubMedCrossRef
12.
Goldberg SN, Grassi CJ, Cardella JF et al (2009) Image-guided tumor ablation: standardization of terminology and reporting criteria. J Vasc Interv Radiol 20:S377–S390PubMedCrossRef
13.
Malloy PC, Grassi CJ, Kundu S et al (2009) Consensus guidelines for periprocedural management of coagulation status and hemostasis risk in percutaneous image-guided interventions. J Vasc Interv Radiol 20:S240–S249PubMedCrossRef
14.
Clark TW, Millward SF, Gervais DA et al (2006) Reporting standards for percutaneous thermal ablation of renal cell carcinoma. J Vasc Interv Radiol 17:1563–1570PubMedCrossRef
15.
Jacobsohn K, Ahrar K, Wood C, Matin SF (2007) Is radiofrequency ablation safe for solitary kidneys? Urology 69:819–823PubMedCrossRef
16.
Syvanthong C, Wile G, Zagoria R (2007) Effect of radiofrequency ablation of renal tumours on renal function in patients with a solitary kidney. AJR Am J Roentgenol 188:1619–1621PubMedCrossRef
17.
Prevoo W, van den Munckhof MP, Meinhardt W, Horenblas S, van den Bosch MA (2010) Radiofrequency ablation of kidney tumours in patients with a solitary kidney. Clin Radiol 65:230–236PubMedCrossRef
18.
Raman JD, Raj GV, Lucas SM et al (2010) Renal functional outcomes for tumours in a solitary kidney managed by ablative or extirpative techniques. BJU Int 105:496–500PubMedCrossRef
19.
Park BK, Kim CK (2009) Complications of image-guided radiofrequency ablation of renal cell carcinoma: causes, imaging features and prevention methods. Eur Radiol 19:2180–2190PubMedCrossRef
20.
Fotiadis NI, Sabharwal T, Morales JP, Hodgson DJ, O’Brien TS, Adam A (2007) Combined percutaneous radiofrequency ablation and ethanol injection of renal tumours: midterm results. Eur Urol 52:777–784PubMedCrossRef
21.
Shankar S, vanSonneberg E, Morrison PR, Tuncali K, Silverman SG (2004) Combined radiofrequency and alcohol injection for percutaneous hepatic tumor ablation. AJR Am J Roentgenol 183:1425–1429PubMedCrossRef
22.
Lee JM, Lee YH, Kim YK, Kim SW, Kim CS (2004) Combined therapy of radiofrequency ablation and ethanol injection of rabbit liver: an in vivo feasibility study. Cardiovasc Interv Radiol 27:151–157
23.
Malcolm JB, Logan JE, Given RW et al (2010) Renal functional outcomes after cryoablation of small renal masses. J Endourol 24:479–482PubMedCrossRef
24.
Weisbrod AJ, Atwell TD, Frank I et al (2010) Percutaneous cryoablation of masses in a solitary kidney. AJR Am J Roentgenol 194:1620–1625PubMedCrossRef
25.
Altunrende F, Autorino R, Hillyer S et al (2011) Image guided percutaneous probe ablation for renal tumors in 65 solitary kidneys: functional and oncological outcomes. J Urol 186:35–41PubMedCrossRef
Metadata
Title
Percutaneous radiofrequency ablation of small renal tumours in patients with a single functioning kidney: long-term results
Authors
Miltiadis Krokidis
Stavros Spiliopoulos
Magdalena Jarzabek
Nikos Fotiadis
Tarun Sabharwal
Tim O’Brien
Andy Adam
Publication date
01-07-2013
Publisher
Springer-Verlag
Published in
European Radiology / Issue 7/2013
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-013-2802-5

Other articles of this Issue 7/2013

European Radiology 7/2013 Go to the issue

Breast

Diagnostic performances of shear wave elastography: which parameter to use in differential diagnosis of solid breast masses?

Interventional

Temporary stent placement with concurrent chemoradiation therapy in patients with unresectable oesophageal carcinoma: is there an optimal time for stent removal?

Interventional

Ten-year experience of percutaneous image-guided radiofrequency ablation of malignant renal tumours in high-risk patients

Magnetic Resonance

Assessment of therapeutic response in ankylosing spondylitis patients undergoing anti-tumour necrosis factor therapy by whole-body magnetic resonance imaging

Neuro

The “central vein sign”: is there a place for susceptibility weighted imaging in possible multiple sclerosis?

Cardiac

Diagnostic accuracy of combined coronary angiography and adenosine stress myocardial perfusion imaging using 320-detector computed tomography: pilot study