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European Radiology
Published in: European Radiology 6/2013

01-06-2013 | Computed Tomography

Relationship between the airway wall area and asthma control score in moderate persistent asthma

Authors: Pierre-Yves Brillet, Philippe A. Grenier, Catalin I. Fetita, Catherine Beigelman-Aubry, Yahya Ould-Hmeidi, Margarete Ortner, Gaëlle Nachbaur, Lukasz Adamek, Pascal Chanez

Published in: European Radiology | Issue 6/2013

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Abstract

Objectives

To assess the association between airway wall area and clinical asthma control, assessed by the Asthma Control Test (ACT).

Methods

This cross-sectional study evaluated 96 adults for asthma control [“at least well controlled” (ACT ≥ 20; n = 52) or “not well controlled” (ACT < 20; n = 44) and airway dimensions: luminal area (LA), wall area (WA) and WA%], obtained using automated dedicated software measurements from volumetric CT images. Results were analysed for segmental bronchi, subsegmental bronchi in the right upper lobe and basilar segments, both uncorrected and corrected for body surface area (BSA).

Results

For all bronchi corrected for BSA, there was no correlation between airway wall area and ACT score. There was a weak but statistically significant correlation between uncorrected WA and ACT score (r = -0.203; P = 0.047); WA values were numerically higher in the “not well-controlled” versus the “at least well-controlled asthma” subgroups. For sub-segmental bronchi, there was a correlation between the ACT score and both WA/BSA (r = -0.204; P = 0.047) and WA (r = -0.249; P = 0.014), and for upper lobe bronchi, between the ACT score and WA (r = -0.207; P = 0.044).

Conclusion

We demonstrated a correlation between subsegmental bronchial airway measurements and clinical control of asthma; this is probably a reflection of airway remodelling and structural changes in chronic poorly controlled asthma.

Key Points

• Volumetric computed tomography offers new insights into bronchial morphology.
• The relationship between current asthma control and airway wall abnormalities is assessed.
• Some relationships between airway wall area and clinical control were demonstrated.
• We observed less shape variation of bronchi in “not well-controlled” asthma patients.
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Metadata
Title
Relationship between the airway wall area and asthma control score in moderate persistent asthma
Authors
Pierre-Yves Brillet
Philippe A. Grenier
Catalin I. Fetita
Catherine Beigelman-Aubry
Yahya Ould-Hmeidi
Margarete Ortner
Gaëlle Nachbaur
Lukasz Adamek
Pascal Chanez
Publication date
01-06-2013
Publisher
Springer-Verlag
Published in
European Radiology / Issue 6/2013
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-012-2743-4

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