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European Radiology
Published in: European Radiology 4/2013

01-04-2013 | Neuro

Albumin-binding MR blood pool contrast agent improves diagnostic performance in human brain tumour: comparison of two contrast agents for glioblastoma

Authors: Josep Puig, Gerard Blasco, Marco Essig, Josep Daunis-i-Estadella, Gemma Laguillo, Ana María Quiles, Sebastián Remollo, Karsten Bergmann, Carme Joly, Lluis Bernado, Javier Sánchez-González, Salvador Pedraza

Published in: European Radiology | Issue 4/2013

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Abstract

Objective

We qualitatively and quantitatively compared MRI enhancement obtained with gadofosveset, an albumin-binding blood-pool contrast agent, and with gadobutrol, an extracellular contrast agent, in patients with glioblastoma.

Methods

Thirty-five patients (25 men; 64 ± 14 years) with histologically proven glioblastoma underwent MRI including pre- and post-contrast T1-weighted SE images acquired 5 min after gadobutrol (0.1 mmol/kg) and, 48 h later, images acquired with identical parameters 5 min and 3, 6, and 24 h after gadofosveset (0.03 mmol/kg). Lesion extent, delineation, internal morphology, multifocality, and global diagnostic preference were evaluated quantitatively for the signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), and contrast enhancement (CE).

Results

Mean values of SNR, CNR, and tumour CE were highest 6 h after gadofosveset. Multifocality was seen in 17 (48.6 %) patients; additional lesions had stronger enhancement 6 h after gadofosveset in 12 patients (70.6 %). In 21 (60 %) patients, radiologists’ global preference was highest in images acquired 6 h after gadofosveset (kappa = 0.764). In 22 patients (62.8 %), all qualitative endpoints were better at 5 min after gadobutrol than in images acquired 5 min after gadofosveset injection.

Conclusions

Gadobutrol gives significant tumour enhancement in early postcontrast imaging. However, images acquired 6 h after gadofosveset injection have significantly better diagnostic information endpoints and contrast enhancement.

Key Points

• We compared MRI enhancement with gadofosveset and gadobutrol in patients with glioblastoma.
• Gadobutrol provides better enhancement in early enhanced imaging at 5 min.
• Gadofosveset at 6 h post-injection provides optimal enhancement and diagnostic information endpoints.
• Gadofosveset is feasible for diagnostic quality contrast-enhanced MRI in glioblastoma.
• The contrast medium dose can be reduced without disminishing the image quality using gadofosveset.
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Metadata
Title
Albumin-binding MR blood pool contrast agent improves diagnostic performance in human brain tumour: comparison of two contrast agents for glioblastoma
Authors
Josep Puig
Gerard Blasco
Marco Essig
Josep Daunis-i-Estadella
Gemma Laguillo
Ana María Quiles
Sebastián Remollo
Karsten Bergmann
Carme Joly
Lluis Bernado
Javier Sánchez-González
Salvador Pedraza
Publication date
01-04-2013
Publisher
Springer-Verlag
Published in
European Radiology / Issue 4/2013
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-012-2678-9

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