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European Radiology
Published in: European Radiology 12/2012

Open Access 01-12-2012 | Cardiac

Value of cardiovascular MR in diagnosing left ventricular non-compaction cardiomyopathy and in discriminating between other cardiomyopathies

Authors: Matthias Grothoff, Milena Pachowsky, Janine Hoffmann, Maximilian Posch, Sabine Klaassen, Lukas Lehmkuhl, Matthias Gutberlet

Published in: European Radiology | Issue 12/2012

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Abstract

Objectives

To analyse the value of cardiovascular magnetic resonance (CMR)-derived myocardial parameters to differentiate left ventricular non-compaction cardiomyopathy (LVNC) from other cardiomyopathies and controls.

Methods

We retrospectively analysed 12 patients with LVNC, 11 with dilated and 10 with hypertrophic cardiomyopathy and compared them to 24 controls. LVNC patients had to fulfil standard echocardiographic criteria as well as additional clinical and imaging criteria. Cine steady-state free precession and late gadolinium enhancement (LGE) imaging was performed. The total LV myocardial mass index (LV-MMI), compacted (LV-MMIcompacted), non-compacted (LV-MMInon-compacted), percentage LV-MMnon-compacted, ventricular volumes and function were calculated. Data were compared using analysis of variance and Dunnett’s test. Additionally, semi-quantitative segmental analyses of the occurrence of increased trabeculation were performed.

Results

Total LV-MMInon-compacted and percentage LV-MMnon-compacted were discriminators between patients with LVCN, healthy controls and those with other cardiomyopathies with cut-offs of 15 g/m2 and 25 %, respectively. Furthermore, trabeculation in basal segments and a ratio of non-compacted/compacted myocardium of ≥3:1 were criteria for LVNC. A combination of these criteria provided sensitivities and specificities of up to 100 %. None of the LVNC patients demonstrated LGE.

Conclusions

Absolute CMR quantification of the LV-MMInon-compacted or the percentage LV-MMnon-compacted and increased trabeculation in basal segments allows one to reliably diagnose LVNC and to differentiate it from other cardiomyopathies.

Key Points

• Cardiac magnetic resonance imaging can reliably diagnose left ventricular non-compaction cardiomyopathy.
• Differentiation of LVNC from other cardiomyopathies and normal hearts is possible.
• The best diagnostic performance can be achieved if combined MRI criteria for the diagnosis are used.
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Metadata
Title
Value of cardiovascular MR in diagnosing left ventricular non-compaction cardiomyopathy and in discriminating between other cardiomyopathies
Authors
Matthias Grothoff
Milena Pachowsky
Janine Hoffmann
Maximilian Posch
Sabine Klaassen
Lukas Lehmkuhl
Matthias Gutberlet
Publication date
01-12-2012
Publisher
Springer-Verlag
Published in
European Radiology / Issue 12/2012
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-012-2554-7

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