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European Radiology

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01-08-2012 | Contrast Media

Arterial input function calculation in dynamic contrast-enhanced MRI: an in vivo validation study using co-registered contrast-enhanced ultrasound imaging

Authors: Hatef Mehrabian, Chaitanya Chandrana, Ian Pang, Rajiv Chopra, Anne L. Martel

Published in: European Radiology | Issue 8/2012

Abstract

Objectives

Developing a method of separating intravascular contrast agent concentration to measure the arterial input function (AIF) in dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) of tumours, and validating its performance in phantom and in vivo experiments.

Methods

A tissue-mimicking phantom was constructed to model leaky tumour vasculature and DCE-MR images of this phantom were acquired. An in vivo study was performed using tumour-bearing rabbits. Co-registered DCE-MRI and contrast-enhanced ultrasound (CEUS) images were acquired. An independent component analysis (ICA)-based method was developed to separate the intravascular component from DCE-MRI. Results were validated by comparing the time-intensity curves with the actual phantom and in vivo curves.

Results

Phantom study: the AIF extracted using ICA correlated well with the true intravascular curve. In vivo study: the AIFs extracted from DCE-MRI using ICA were very close to the true AIF. Intravascular component images were very similar to the CEUS images. The contrast onset times and initial wash-in slope of the ICA-derived AIF showed good agreement with the CEUS curves.

Conclusion

ICA has the potential to separate the intravascular component from DCE-MRI. This could eliminate the requirement for contrast medium uptake measurements in a major artery and potentially result in more accurate pharmacokinetic parameters.

Key Points

• Tumour response to therapy can be inferred from pharmacokinetic parameters.

• Arterial input function (AIF) is required for pharmacokinetic modelling of tumours.

• Independent component analysis has the potential to measure AIF inside the tumour.

• AIF measurement is validated using contrast enhanced ultrasound and phantoms.

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Title: Arterial input function calculation in dynamic contrast-enhanced MRI: an in vivo validation study using co-registered contrast-enhanced ultrasound imaging
Authors: Hatef Mehrabian
Chaitanya Chandrana
Ian Pang
Rajiv Chopra
Anne L. Martel
Publication date: 01-08-2012
Publisher: Springer-Verlag
Published in: European Radiology / Issue 8/2012
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-012-2418-1

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Arterial input function calculation in dynamic contrast-enhanced MRI: an in vivo validation study using co-registered contrast-enhanced ultrasound imaging

Abstract

Objectives

Methods

Results

Conclusion

Key Points

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusion

Key Points

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