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European Radiology
Published in: European Radiology 9/2011

01-09-2011 | Ultrasound

Ultrasound features of malignancy in the preoperative diagnosis of parathyroid cancer: a retrospective analysis of parathyroid tumours larger than 15 mm

Authors: Paul S. Sidhu, Nadia Talat, Preena Patel, Nicola J. Mulholland, Klaus-Martin Schulte

Published in: European Radiology | Issue 9/2011

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Abstract

Objective

Nearly all reported parathyroid cancers are >15 mm at presentation. The objective was to identify ultrasound criteria of malignancy in parathyroid lesions of >15 mm in size.

Materials and methods

This study was approved by a local ethics committee. A retrospective review of patients identified from a database from 2004–2009 was performed. All patients underwent ultrasound imaging according to the protocol. Two trained observers categorized findings using the pre-determined features: shape, calcification, pattern of vascularity, local infiltration and internal lesion gray scale appearances.

Results

Sixty-nine patients (mean age 54.3 years, range 19–79 years; male = 16, female = 53) fulfilled the criteria of a parathyroid lesion >15 mm; 8/69 (11.6%) with parathyroid cancer and 61/69 (88.4%) with benign solitary parathyroid adenoma. A high positive predictive value (PPV) for cancer was identified for infiltration (PPV 100%) and calcification (PPV 100%), whilst a high negative predictive value (NPV) was found for the absence of suspicious vascularity (NPV 97.6%), a thick capsule (NPV 96.7) and inhomogeneity (NPV 100%).

Conclusion

In lesions >15 mm systematic ultrasound assessment of specific features provides a valuable tool to identify parathyroid cancers before surgery.
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Metadata
Title
Ultrasound features of malignancy in the preoperative diagnosis of parathyroid cancer: a retrospective analysis of parathyroid tumours larger than 15 mm
Authors
Paul S. Sidhu
Nadia Talat
Preena Patel
Nicola J. Mulholland
Klaus-Martin Schulte
Publication date
01-09-2011
Publisher
Springer-Verlag
Published in
European Radiology / Issue 9/2011
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-011-2141-3

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