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Published in: European Radiology 8/2011

01-08-2011 | Magnetic Resonance

Diagnostic value of 3D contrast-enhanced magnetic resonance angiography in Takayasu’s arteritis—a comparative study with digital subtraction angiography

Authors: Shobhit K. Garg, Suyash Mohan, Sunil Kumar

Published in: European Radiology | Issue 8/2011

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Abstract

Objective

To assess the diagnostic value of 3D CEMRA in TA compared with DSA.

Methods

Twenty-two patients with clinically suspected TA based on 1990 ACR criteria for the classification of TA, were included in this study. There were 16 female and 6 male patients with ages ranging from 11 to 50 years (mean age 25 years). CEMRA and DSA were performed in all patients within 4 weeks of each other, for detection of stenosis, occlusion and aneurysm in the arch vessels, renal arteries and aortic segments.

Results

(1) TA was confirmed by CEMRA in all patients. (2) 147 arteries did not reveal any steno-occlusive lesion on CEMRA compared with 158 on DSA. (3) 75 stenoses, (excluding occlusions) were detected on CEMRA compared with DSA, which revealed 65 stenotic lesions, with sensitivity, specificity, PPV, NPV and DA for detection of a significant (>50%) stenotic lesion being 98.33%, 97.25%, 92.18%, 99.43% and 97.52% respectively. (4) Aneurysmal dilatation was detected in 13 arteries on CEMRA compared with 16 on DSA.

Conclusions

Diagnostic value of CEMRA is comparable to that of DSA with a very strong and statistically significant correlation between DSA and CEMRA in detection and grading of characteristic steno-occlusive lesions of TA.
Literature
1.
2.
go back to reference Fauci AS (2001) The vasculitis syndromes. In: Braunwald E, Fauci AS, Kasper DL, Hauser SL, Longo DL, Jameson JL (eds) Harrison’s principles of internal medicine. McGraw Hill, New York, pp 1956–1958 Fauci AS (2001) The vasculitis syndromes. In: Braunwald E, Fauci AS, Kasper DL, Hauser SL, Longo DL, Jameson JL (eds) Harrison’s principles of internal medicine. McGraw Hill, New York, pp 1956–1958
3.
go back to reference Hall S, Barr W, Lie JT, Stanson AW, Kazmier FJ, Hunder GG (1985) Takayasu arteritis. A study of 32 North American patients. Medicine 64:89–99PubMedCrossRef Hall S, Barr W, Lie JT, Stanson AW, Kazmier FJ, Hunder GG (1985) Takayasu arteritis. A study of 32 North American patients. Medicine 64:89–99PubMedCrossRef
4.
go back to reference Hellmann DB, Flynn JA (1998) Clinical presentation and natural history of Takayasu’s arteritis and other inflammatory arteritides. In: Perler BA, Becker GJ (eds) Vascular Intervention: a clinical approach, vol. 24. Thieme, New York, pp 249–256 Hellmann DB, Flynn JA (1998) Clinical presentation and natural history of Takayasu’s arteritis and other inflammatory arteritides. In: Perler BA, Becker GJ (eds) Vascular Intervention: a clinical approach, vol. 24. Thieme, New York, pp 249–256
5.
go back to reference Lande A, Berkmen YM, McAllister HA Jr (eds) (1986) Aortitis: clinical, pathologic, and radiologic aspects. Raven, New York, pp 55–80, 173–192 Lande A, Berkmen YM, McAllister HA Jr (eds) (1986) Aortitis: clinical, pathologic, and radiologic aspects. Raven, New York, pp 55–80, 173–192
6.
go back to reference Yamada I, Nakagawa T, Himeno Y, Kobayashi Y, Numano F, Shibuya H (2000) Takayasu’s arteritis: diagnosis with breath-hold contrast enhanced 3D MR angiography. J Magn Reson Imaging 11:481–487PubMedCrossRef Yamada I, Nakagawa T, Himeno Y, Kobayashi Y, Numano F, Shibuya H (2000) Takayasu’s arteritis: diagnosis with breath-hold contrast enhanced 3D MR angiography. J Magn Reson Imaging 11:481–487PubMedCrossRef
7.
go back to reference Raninen RO, Kupari MM, Pamilo MS et al (1996) Arterial wall thickness measurements by B mode ultrasonography in patients with Takayasu’s arteritis. Ann Rheum Dis 55:461–465PubMedCrossRef Raninen RO, Kupari MM, Pamilo MS et al (1996) Arterial wall thickness measurements by B mode ultrasonography in patients with Takayasu’s arteritis. Ann Rheum Dis 55:461–465PubMedCrossRef
8.
go back to reference Yamada I, Numano F, Sujuki S (1993) Takayasu’s arteritis: evaluation with MR imaging. Radiology 188:89–94PubMed Yamada I, Numano F, Sujuki S (1993) Takayasu’s arteritis: evaluation with MR imaging. Radiology 188:89–94PubMed
9.
go back to reference Krinsky GA, Rofsky NM, De Corato DR et al (1997) Thoracic aorta: comparison of gadolinium-enhanced three-dimensional MR angiography with conventional MR imaging. Radiology 202:183–193PubMed Krinsky GA, Rofsky NM, De Corato DR et al (1997) Thoracic aorta: comparison of gadolinium-enhanced three-dimensional MR angiography with conventional MR imaging. Radiology 202:183–193PubMed
10.
go back to reference Park JH (1996) Conventional and CT angiographic diagnosis of Takayasu arteritis. Int J Cardiol 54(Suppl):S165–S171PubMedCrossRef Park JH (1996) Conventional and CT angiographic diagnosis of Takayasu arteritis. Int J Cardiol 54(Suppl):S165–S171PubMedCrossRef
11.
go back to reference De Leeuw K, Bijl M, Jager PL (2004) Additional value of positron emission tomography in diagnosis and follow-up of patients with large vessel vasculitides. Clin Exp Rheumatol 22(6 Suppl 36):S21–S26PubMed De Leeuw K, Bijl M, Jager PL (2004) Additional value of positron emission tomography in diagnosis and follow-up of patients with large vessel vasculitides. Clin Exp Rheumatol 22(6 Suppl 36):S21–S26PubMed
12.
go back to reference Canyigit M, Peynircioglu B, Hazirolan T, Dagoglu MG, Cil BE, Haliloglu M, Balkanci F, Besim A (2007) Imaging characteristics of Takayasu arteritis. Cardiovasc Interv Radiol 30:711–718CrossRef Canyigit M, Peynircioglu B, Hazirolan T, Dagoglu MG, Cil BE, Haliloglu M, Balkanci F, Besim A (2007) Imaging characteristics of Takayasu arteritis. Cardiovasc Interv Radiol 30:711–718CrossRef
13.
go back to reference Kissin EY, Merkel PA (2004) Diagnostic imaging in Takayasu arteritis. Curr Opin Rheumatol 16:31–37PubMedCrossRef Kissin EY, Merkel PA (2004) Diagnostic imaging in Takayasu arteritis. Curr Opin Rheumatol 16:31–37PubMedCrossRef
14.
go back to reference Prince MR, Yucel EK, Kaufman JA, Harrison DC, Geller SC (1993) Dynamic gadolinium-enhanced three-dimensional abdominal MR arteriography. J Magn Reson Imaging 3:877–881PubMedCrossRef Prince MR, Yucel EK, Kaufman JA, Harrison DC, Geller SC (1993) Dynamic gadolinium-enhanced three-dimensional abdominal MR arteriography. J Magn Reson Imaging 3:877–881PubMedCrossRef
15.
go back to reference Prince MR, Narasimham DL, Jacoby WT et al (1996) Three-dimensional gadolinium enhanced MR angiography of the thoracic aorta. AJR Am J Roentgenol 166:1387–1397PubMed Prince MR, Narasimham DL, Jacoby WT et al (1996) Three-dimensional gadolinium enhanced MR angiography of the thoracic aorta. AJR Am J Roentgenol 166:1387–1397PubMed
16.
go back to reference Kerr GS, Hallahan CW, Giordano J et al (1994) Takayasu arteritis. Ann Intern Med 120:919–929PubMed Kerr GS, Hallahan CW, Giordano J et al (1994) Takayasu arteritis. Ann Intern Med 120:919–929PubMed
17.
go back to reference Aluquin VP, Albano SA, Chan F, Sandborg C, Pitlick PT (2002) Magnetic resonance imaging in the diagnosis and follow up of Takayasu’s arteritis in children. Ann Rheum Dis 61:526–529PubMedCrossRef Aluquin VP, Albano SA, Chan F, Sandborg C, Pitlick PT (2002) Magnetic resonance imaging in the diagnosis and follow up of Takayasu’s arteritis in children. Ann Rheum Dis 61:526–529PubMedCrossRef
18.
go back to reference Choe YH, Kim DK, Koh EM, Do YS, Lee WR (1999) Takayasu’s arteritis: diagnosis with MR imaging and MR angiography in acute and chronic active stages. J Magn Reson Imaging 10:751–757PubMedCrossRef Choe YH, Kim DK, Koh EM, Do YS, Lee WR (1999) Takayasu’s arteritis: diagnosis with MR imaging and MR angiography in acute and chronic active stages. J Magn Reson Imaging 10:751–757PubMedCrossRef
19.
go back to reference Choe YH, Han BK, Koh EM, Kim DK, Do YS, Lee WR (2000) Takayasu’s arteritis: assessment of disease activity with contrast-enhanced MR imaging. Am J Roentgenol 175:505–511 Choe YH, Han BK, Koh EM, Kim DK, Do YS, Lee WR (2000) Takayasu’s arteritis: assessment of disease activity with contrast-enhanced MR imaging. Am J Roentgenol 175:505–511
20.
go back to reference Itazawa T, Noguchi K, Ichida F, Miyawaki T (2001) Magnetic resonance imaging of early detection of Takayasu’s arteritis. Pediatr Cardiol 22:163–164PubMedCrossRef Itazawa T, Noguchi K, Ichida F, Miyawaki T (2001) Magnetic resonance imaging of early detection of Takayasu’s arteritis. Pediatr Cardiol 22:163–164PubMedCrossRef
21.
go back to reference Meller J, Grabbe E, Becker W, Vosshenrich R (2003) Value of F-18 FDG hybrid camera PET and MRI in early Takayasu’s aortitis. Eur Radiol 13:400–405PubMed Meller J, Grabbe E, Becker W, Vosshenrich R (2003) Value of F-18 FDG hybrid camera PET and MRI in early Takayasu’s aortitis. Eur Radiol 13:400–405PubMed
22.
go back to reference Prince MR, Narasimham DL, Stanley JC et al (1995) Breath-hold gadolinium-enhanced MR angiography of the abdominal aorta and its major branches. Radiology 197:785–792PubMed Prince MR, Narasimham DL, Stanley JC et al (1995) Breath-hold gadolinium-enhanced MR angiography of the abdominal aorta and its major branches. Radiology 197:785–792PubMed
23.
go back to reference Stone JA, Mukherji SK, Semelka R, Kelekis N, Neelan B, Cashillo M (2000) Contrast enhanced 3D FISP MR angiography of aortic arch ostia: preliminary results. J Comput Assist Tomogr 24:369–374PubMedCrossRef Stone JA, Mukherji SK, Semelka R, Kelekis N, Neelan B, Cashillo M (2000) Contrast enhanced 3D FISP MR angiography of aortic arch ostia: preliminary results. J Comput Assist Tomogr 24:369–374PubMedCrossRef
24.
go back to reference Hany TF, Debatin JF, Leung DA, Pfammatter T (1997) Evaluation of the aortoiliac and renal arteries: comparison of breath-hold, contrast-enhanced, three-dimensional MR angiography with conventional catheter angiography. Radiology 204:357–362PubMed Hany TF, Debatin JF, Leung DA, Pfammatter T (1997) Evaluation of the aortoiliac and renal arteries: comparison of breath-hold, contrast-enhanced, three-dimensional MR angiography with conventional catheter angiography. Radiology 204:357–362PubMed
25.
go back to reference Mitsuzaki K, Yamashita Y, Sakaguchi T, Ogata I, Takahashi M, Hiai Y (2000) Abdomen pelvis and extremities: diagnostic accuracy of dynamic CE—Turbo MRA with conventional angiography—initial experience. Radiology 216:909–915PubMed Mitsuzaki K, Yamashita Y, Sakaguchi T, Ogata I, Takahashi M, Hiai Y (2000) Abdomen pelvis and extremities: diagnostic accuracy of dynamic CE—Turbo MRA with conventional angiography—initial experience. Radiology 216:909–915PubMed
26.
go back to reference Randoux B, Marro B, Koskas F, Chiras J, Dormont D, Marsault C (2003) Proximal great vessels of aortic arch: comparison of three-dimensional gadolinium-enhanced MR angiography and digital subtraction angiography. Radiology 229:697–702PubMedCrossRef Randoux B, Marro B, Koskas F, Chiras J, Dormont D, Marsault C (2003) Proximal great vessels of aortic arch: comparison of three-dimensional gadolinium-enhanced MR angiography and digital subtraction angiography. Radiology 229:697–702PubMedCrossRef
27.
go back to reference DeCobelli F, Venturini M, Vanzulli A et al (2000) Renal arterial stenosis: prospective comparison of color doppler US and breath-hold 3D dynamic gadolinium enhanced MRA. Radiology 214:373–380 DeCobelli F, Venturini M, Vanzulli A et al (2000) Renal arterial stenosis: prospective comparison of color doppler US and breath-hold 3D dynamic gadolinium enhanced MRA. Radiology 214:373–380
28.
go back to reference Lee VS, Martin DJ, Krinsky GA, Rofsky NM (2000) Gadolinium-enhanced MR angiography: artifacts and pitfalls. AJR Am J Roentgenol 175:197–205PubMed Lee VS, Martin DJ, Krinsky GA, Rofsky NM (2000) Gadolinium-enhanced MR angiography: artifacts and pitfalls. AJR Am J Roentgenol 175:197–205PubMed
29.
go back to reference Both M, Reinhold-Keller E, Müller-Hülsbeck S, Biederer J, Gross WL, Heller M, Reuter M (2004) Inflammatory aortic arch syndrome: contrast-enhanced, three-dimensional MR angiography in stenotic lesions. Rofo 176:48–55PubMed Both M, Reinhold-Keller E, Müller-Hülsbeck S, Biederer J, Gross WL, Heller M, Reuter M (2004) Inflammatory aortic arch syndrome: contrast-enhanced, three-dimensional MR angiography in stenotic lesions. Rofo 176:48–55PubMed
30.
31.
go back to reference Steffens JC, Link J, Grassner J et al (1997) Contrast-enhanced, K-space-centered, breath-hold MR angiography of the renal arteries and the abdominal aorta. J Magn Reson Imaging 7:617–622PubMedCrossRef Steffens JC, Link J, Grassner J et al (1997) Contrast-enhanced, K-space-centered, breath-hold MR angiography of the renal arteries and the abdominal aorta. J Magn Reson Imaging 7:617–622PubMedCrossRef
32.
go back to reference Masunaga H, Takehara Y, Isoda H et al (2001) Assessment of gadolinium-enhanced time resolved 3D MRA for evaluating renal artery stenosis. Am J Roentgenol 176:1213–1219 Masunaga H, Takehara Y, Isoda H et al (2001) Assessment of gadolinium-enhanced time resolved 3D MRA for evaluating renal artery stenosis. Am J Roentgenol 176:1213–1219
33.
go back to reference Van Hoe L, De Jaegere T, Bosmans H et al (2000) Breath-hold contrast-enhanced three-dimensional MR angiography of the abdomen: time resolved imaging versus single phase imaging. Radiology 214:149–156PubMed Van Hoe L, De Jaegere T, Bosmans H et al (2000) Breath-hold contrast-enhanced three-dimensional MR angiography of the abdomen: time resolved imaging versus single phase imaging. Radiology 214:149–156PubMed
34.
go back to reference Korst MB, Joosten FBM, Postma CT, Jager GJ, Krabbe JK, Barentsz JO (2000) Accuracy of normal dose CE-MRA in assessing renal artery stenosis and accessory renal arteries. Am J Roentgenol 174:629–634 Korst MB, Joosten FBM, Postma CT, Jager GJ, Krabbe JK, Barentsz JO (2000) Accuracy of normal dose CE-MRA in assessing renal artery stenosis and accessory renal arteries. Am J Roentgenol 174:629–634
35.
go back to reference Nippon Igaku Hoshasen Gakkai Zasshi (2000) Contrast-enhanced three-dimensional angiography. Nippon acta radiologica, Journal of Japan Radiological Society 60:493–499 Nippon Igaku Hoshasen Gakkai Zasshi (2000) Contrast-enhanced three-dimensional angiography. Nippon acta radiologica, Journal of Japan Radiological Society 60:493–499
36.
go back to reference Nastri VM, Baptista LP, Baroni RH et al (2004) Gadolinium-enhanced three-dimensional MR angiography of Takayasu’s arteritis. Radiographics 24:773–786PubMedCrossRef Nastri VM, Baptista LP, Baroni RH et al (2004) Gadolinium-enhanced three-dimensional MR angiography of Takayasu’s arteritis. Radiographics 24:773–786PubMedCrossRef
Metadata
Title
Diagnostic value of 3D contrast-enhanced magnetic resonance angiography in Takayasu’s arteritis—a comparative study with digital subtraction angiography
Authors
Shobhit K. Garg
Suyash Mohan
Sunil Kumar
Publication date
01-08-2011
Publisher
Springer-Verlag
Published in
European Radiology / Issue 8/2011
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-011-2090-x

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