Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
European Radiology
Published in: European Radiology 7/2011

Open Access 01-07-2011 | Musculoskeletal

Predictive factors for new onset or progression of knee osteoarthritis one year after trauma: MRI follow-up in general practice

Authors: Ingrid M. Koster, Edwin H. G. Oei, Jan-Hein J. Hensen, Simone S. Boks, Bart W. Koes, Dammis Vroegindeweij, M. G. Myriam Hunink, Sita M. A. Bierma-Zeinstra

Published in: European Radiology | Issue 7/2011

Login to get access

Abstract

Objective

To prospectively evaluate prognostic factors for new onset or progression of degenerative change on follow-up MRI one year after knee trauma and the association with clinical outcome.

Methods

Within a prospective observational cohort study in general practice, we studied a subgroup of 117 patients with acute knee trauma (mean age 41 years, 43% women). Degenerative change was scored on MRI at baseline and after one year follow-up. Multivariate logistic regression analysis was performed to evaluate prognostic factors for new onset or progressive degenerative change on follow-up MRI. Association between new or progressive degeneration and clinical outcome after one year was assessed.

Results

On follow-up MRI 15% of patients with pre-existing knee osteoarthritis showed progression and 26% of patients demonstrated new degenerative change. The only statistically significant prognostic variable in the multivariate analysis was bone marrow oedema on initial MRI (OR 5.29 (95% CI 1.64–17.1), p = 0.005). A significant association between new or progressive degenerative change and clinical outcome was found (p = 0.003).

Conclusion

Bone marrow oedema on MRI for acute knee injury is strongly predictive of new onset or progression of degenerative change of the femorotibial joint on follow-up MRI one year after trauma, which is reflected in clinical outcome.
Literature
1.
2.
Spector TD, Hart DJ, Doyle DV (1994) Incidence and progression of osteoarthritis in women with unilateral knee disease in the general population: the effect of obesity. Ann Rheum Dis 53:565–568PubMedCrossRef
3.
Roos EM (2005) Joint injury causes knee osteoarthritis in young adults. Curr Opin Rheumatol 17:195–200PubMedCrossRef
4.
Reijman M, Pols HA, Bergink AP et al (2007) Body mass index associated with onset and progression of osteoarthritis of the knee but not of the hip: the Rotterdam Study. Ann Rheum Dis 66:158–162PubMedCrossRef
5.
Van der Linden MW, Westert GP, de Bakker DH, Schellevis FG (2004) Tweede nationale studie naar ziekten en verrichtingen in de huisartspraktijk: klachten en aandoeningen in de bevolking en in de huisartspraktijk. Nivel, Rijksinstituut voor volksgezondheid en milieu, Utrecht, Bilthoven
6.
Berthiaume MJ, Raynauld JP, Martel-Pelletier J et al (2005) Meniscal tear and extrusion are strongly associated with progression of symptomatic knee osteoarthritis as assessed by quantitative magnetic resonance imaging. Ann Rheum Dis 64:556–563PubMedCrossRef
7.
Sharma L, Eckstein F, Song J et al (2008) Relationship of meniscal damage, meniscal extrusion, malalignment, and joint laxity to subsequent cartilage loss in osteoarthritic knees. Arthritis Rheum 58:1716–1726PubMedCrossRef
8.
Lohmander LS, Englund PM, Dahl LL, Roos EM (2007) The long-term consequence of anterior cruciate ligament and meniscus injuries: osteoarthritis. Am J Sports Med 35:1756–1769PubMedCrossRef
9.
Felson DT, McLaughlin S, Goggins J et al (2003) Bone marrow edema and its relation to progression of knee osteoarthritis. Ann Intern Med 139:330–336PubMed
10.
Libicher M, Ivancic M, Hoffmann M, Wenz W (2005) Early changes in experimental osteoarthritis using the Pond-Nuki dog model: technical procedure and initial results of in vivo MR imaging. Eur Radiol 15:390–394PubMedCrossRef
11.
Spector TD, Hart DJ, Huskisson EC (1991) The use of radiographs in assessing the severity of knee osteoarthritis. J Rheumatol Suppl 27:38–39PubMed
12.
Lawrence JS, Bremner JM, Bier F (1966) Osteo-arthrosis. Prevalence in the population and relationship between symptoms and x-ray changes. Ann Rheum Dis 25:1–24PubMed
13.
Kijowski R, Blankenbaker DG, Stanton PT, Fine JP, De Smet AA (2006) Radiographic findings of osteoarthritis versus arthroscopic findings of articular cartilage degeneration in the tibiofemoral joint. Radiology 239:818–824PubMedCrossRef
14.
Link TM, Steinbach LS, Ghosh S et al (2003) Osteoarthritis: MR imaging findings in different stages of disease and correlation with clinical findings. Radiology 226:373–381PubMedCrossRef
15.
Peterfy CG, Guermazi A, Zaim S et al (2004) Whole-Organ Magnetic Resonance Imaging Score (WORMS) of the knee in osteoarthritis. Osteoarthritis Cartilage 12:177–190PubMedCrossRef
16.
Heintjes EM, Berger MY, Koes BW, Bierma-Zeinstra SM (2005) Knee disorders in primary care: design and patient selection of the HONEUR knee cohort. BMC Musculoskelet Disord 6:45PubMedCrossRef
17.
Boks SS, Vroegindeweij D, Koes BW, Hunink MM, Bierma-Zeinstra SM (2006) Magnetic resonance imaging abnormalities in symptomatic and contralateral knees: prevalence and associations with traumatic history in general practice. Am J Sports Med 34:1984–1991PubMedCrossRef
18.
Kornaat PR, Ceulemans RY, Kroon HM et al (2005) MRI assessment of knee osteoarthritis: Knee Osteoarthritis Scoring System (KOSS)–inter-observer and intra-observer reproducibility of a compartment-based scoring system. Skeletal Radiol 34:95–102PubMedCrossRef
19.
Petersson IF, Boegard T, Saxne T, Silman AJ, Svensson B (1997) Radiographic osteoarthritis of the knee classified by the Ahlback and Kellgren & Lawrence systems for the tibiofemoral joint in people aged 35–54 years with chronic knee pain. Ann Rheum Dis 56:493–496PubMedCrossRef
20.
Herr KA, Spratt K, Mobily PR, Richardson G (2004) Pain intensity assessment in older adults: use of experimental pain to compare psychometric properties and usability of selected pain scales with younger adults. Clin J Pain 20:207–219PubMedCrossRef
21.
Briggs KK, Kocher MS, Rodkey WG, Steadman JR (2006) Reliability, validity, and responsiveness of the Lysholm knee score and Tegner activity scale for patients with meniscal injury of the knee. J Bone Joint Surg Am 88:698–705PubMedCrossRef
22.
Van der Heijden GJ, Donders AR, Stijnen T, Moons KG (2006) Imputation of missing values is superior to complete case analysis and the missing-indicator method in multivariable diagnostic research: a clinical example. J Clin Epidemiol 59:1102–1109PubMedCrossRef
23.
Schafer J (1997) Analysis of incomplete multivariate data. Chapman & Hall, LondonCrossRef
24.
Cooper C, Snow S, McAlindon TE et al (2000) Risk factors for the incidence and progression of radiographic knee osteoarthritis. Arthritis Rheum 43:995–1000PubMedCrossRef
25.
Hochberg MC, Lethbridge-Cejku M, Scott WW Jr, Reichle R, Plato CC, Tobin JD (1995) The association of body weight, body fatness and body fat distribution with osteoarthritis of the knee: data from the Baltimore Longitudinal Study of Aging. J Rheumatol 22:488–493PubMed
26.
Kubota M, Ishijima M, Kurosawa H et al (2010) A longitudinal study of the relationship between the status of bone marrow abnormalities and progression of knee osteoarthritis. J Orthop Sci 15:641–646PubMedCrossRef
27.
Thiryayi WA, Thiryayi SA, Freemont AJ (2008) Histopathological perspective on bone marrow oedema, reactive bone change and haemorrhage. Eur J Radiol 67:62–67PubMedCrossRef
28.
Boks SS, Vroegindeweij D, Koes BW, Bernsen RM, Hunink MG, Bierma-Zeinstra SM (2007) MRI follow-up of posttraumatic bone bruises of the knee in general practice. AJR Am J Roentgenol 189:556–562PubMedCrossRef
Metadata
Title
Predictive factors for new onset or progression of knee osteoarthritis one year after trauma: MRI follow-up in general practice
Authors
Ingrid M. Koster
Edwin H. G. Oei
Jan-Hein J. Hensen
Simone S. Boks
Bart W. Koes
Dammis Vroegindeweij
M. G. Myriam Hunink
Sita M. A. Bierma-Zeinstra
Publication date
01-07-2011
Publisher
Springer-Verlag
Published in
European Radiology / Issue 7/2011
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-011-2089-3

Other articles of this Issue 7/2011

European Radiology 7/2011 Go to the issue

Musculoskeletal

Tears at the rotator cuff footprint: Prevalence and imaging characteristics in 305 MR arthrograms of the shoulder

Book Review

Recent literature

Gastrointestinal

A comparison of the Accuracy of Ultrasound and Computed Tomography in common diagnoses causing acute abdominal pain

Chest

Low-dose triple-rule-out using 320-row-detector volume MDCT – less contrast medium and lower radiation exposure

Erratum

Erratum to: Influence of statin treatment on coronary atherosclerosis visualised using multidetector computed tomography

Urogenital

Diagnosis of colorectal endometriosis: contribution of contrast enhanced MR-colonography