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European Radiology
Published in: European Radiology 5/2011

01-05-2011 | Urogenital

Prediction of biochemical recurrence following radical prostatectomy in men with prostate cancer by diffusion-weighted magnetic resonance imaging: initial results

Authors: Sung Yoon Park, Chan Kyo Kim, Byung Kwan Park, Hyun Moo Lee, Kyung Soo Lee

Published in: European Radiology | Issue 5/2011

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Abstract

Objective

To retrospectively assess the apparent diffusion coefficient (ADC) as a predictor of biochemical recurrence (BCR) after surgery in patients with localised prostate cancer.

Methods

Enrolled in this study were 158 men who underwent surgery between 2005 and 2007 with preoperative diffusion-weighted MR imaging (DWI) at 3 T, and who received follow-up for a median of 24 months (range, 12–57 months). Univariate and multivariate analyses including all clinical variables and tumour ADC data were performed with respect to BCR. Receiver operating characteristic (ROC) analysis was also performed to assess diagnostic performance of variables in the prediction of BCR.

Results

Thirty patients (19%) who received surgery had BCR. Univariate analysis revealed that tumour ADC, Gleason score at biopsy and surgical specimen, serum PSA, greatest percentage of cancer in biopsy core, percentage of positive cores in all biopsy cores and tumour volume were all significantly related to BCR. However, multivariate analysis identified tumour ADC as the only independently predictive factor. For predicting BCR, area under the curve for tumour ADC was 0.755, and tumour ADC showed better diagnostic performance than that of all other variables.

Conclusion

Tumour ADC on DWI may be a predictive biomarker for BCR following radical prostatectomy.
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Metadata
Title
Prediction of biochemical recurrence following radical prostatectomy in men with prostate cancer by diffusion-weighted magnetic resonance imaging: initial results
Authors
Sung Yoon Park
Chan Kyo Kim
Byung Kwan Park
Hyun Moo Lee
Kyung Soo Lee
Publication date
01-05-2011
Publisher
Springer-Verlag
Published in
European Radiology / Issue 5/2011
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-010-1999-9

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