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01-02-2011 | Molecular Imaging

Diagnostic accuracy of whole-body MRI/DWI image fusion for detection of malignant tumours: a comparison with PET/CT

Authors: Michael A. Fischer, Daniel Nanz, Thomas Hany, Caecilia S. Reiner, Paul Stolzmann, Olivio F. Donati, Stefan Breitenstein, Paul Schneider, Dominik Weishaupt, Gustav K. von Schulthess, Hans Scheffel

Published in: European Radiology | Issue 2/2011

Abstract

Objective

To prospectively evaluate the diagnostic accuracy of whole-body T2-weighted (wbT2), whole-body diffusion-weighted imaging (wbDWI) and wbT2/wbDWI image fusion for malignant tumour detection compared with PET/CT.

Methods

Sixty-eight patients (44 men; 60 ± 14 years) underwent PET/CT for staging of malignancy and were consecutively examined by 1.5-Tesla MRI including wbT2 and wbDWI. Two radiologists independently assessed wbDWI, wbT2, wbT2 + wbDWI (side-by-side) and wbT2 + wbDWI + wbT2/wbDWI image fusion for the presence of malignancy. PET/CT served as a reference standard.

Results

PET/CT revealed 374 malignant lesions in 48/64 (75%) patients. Detection rates and positive predictive value (PPV) of wbT2 and wbDWI alone were 64% and 84%, and 57% and 93%, respectively. Detection rates and PPV of wbT2 and wbDWI for side-by-side analysis without and with fused images were 72% and 89%, and 74% and 91%, respectively. The detection rate was significantly higher with side-by-side analysis and fused image analysis compared with wbT2 and wbDWI alone (p = .0159; p < .0001). There was no significant difference between fused image interpretation and side-by-side analysis.

Conclusions

WbDWI allows detection of malignant lesions with a similar detection rate to wbT2. Side-by-side analysis of wbT2 and wbDWI significantly improves the overall detection rate and fused image data provides no added value.

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Title: Diagnostic accuracy of whole-body MRI/DWI image fusion for detection of malignant tumours: a comparison with PET/CT
Authors: Michael A. Fischer
Daniel Nanz
Thomas Hany
Caecilia S. Reiner
Paul Stolzmann
Olivio F. Donati
Stefan Breitenstein
Paul Schneider
Dominik Weishaupt
Gustav K. von Schulthess
Hans Scheffel
Publication date: 01-02-2011
Publisher: Springer-Verlag
Published in: European Radiology / Issue 2/2011
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-010-1929-x

At a glance: The STEP trials

Springer Medicine

Diagnostic accuracy of whole-body MRI/DWI image fusion for detection of malignant tumours: a comparison with PET/CT

Abstract

Objective

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Objective

Methods

Results

Conclusions

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