Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
European Radiology
Published in: European Radiology 12/2010

01-12-2010 | Magnetic Resonance

Comparison of a new whole-body continuous-table-movement protocol versus a standard whole-body MR protocol for the assessment of multiple myeloma

Authors: S. Weckbach, H. J. Michaely, A. Stemmer, S. O. Schoenberg, D. J. Dinter

Published in: European Radiology | Issue 12/2010

Login to get access

Abstract

Objectives

To evaluate a whole body (WB) continuous-table-movement (CTM) MR protocol for the assessment of multiple myeloma (MM) in comparison to a step-by-step WB protocol.

Methods

Eighteen patients with MM were examined at 1.5T using a WB CTM protocol (axial T2-w fs BLADE, T1-w GRE sequence) and a step-by-step WB protocol including coronal/sagittal T1-w SE and STIR sequences as reference. Protocol time was assessed. Image quality, artefacts, liver/spleen assessability, and the ability to depict bone marrow lesions less than or greater than 1 cm as well as diffuse infiltration and soft tissue lesions were rated. Potential changes in the Durie and Salmon Plus stage and the detectability of complications were assessed.

Results

Mean protocol time was 6:38 min (CTM) compared to 24:32 min (standard). Image quality was comparable. Artefacts were more prominent using the CTM protocol (P = 0.0039). Organ assessability was better using the CTM protocol (P < 0.001). Depiction of bone marrow and soft tissue lesions was identical without a staging shift. Vertebral fractures were not detected using the CTM protocol.

Conclusions

The new protocol allows a higher patient throughput and facilitates the depiction of extramedullary lesions. However, as long as vertebral fractures are not detectable, the protocol cannot be safely used for clinical routine without the acquisition of an additional sagittal sequence.
Literature
1.
2.
3.
Durie BG (2006) The role of anatomic and functional staging in myeloma: description of Durie/Salmon Plus staging system. Eur J Cancer 42:1539–1543CrossRefPubMed
4.
Baur A, Stabler A, Nagel D et al (2002) Magnetic resonance imaging as a supplement for the clinical staging system of Durie and Salmon? Cancer 95:1334–1345CrossRefPubMed
5.
Baur-Melnyk A, Buhmann S, Durr HR, Reiser M (2005) Role of MRI for the diagnosis and prognosis of multiple myeloma. Eur J Radiol 55:56–63CrossRefPubMed
6.
Bauerle T, Hillengass J, Fechtner K et al (2009) Multiple myeloma and monoclonal gammopathy of undetermined significance: importance of whole-body versus spinal MR imaging. Radiology 252:477–485CrossRefPubMed
7.
8.
Baur-Melnyk A, Buhmann S, Becker C et al (2008) Whole-body MRI versus whole-body MDCT for staging of multiple myeloma. AJR Am J Roentgenol 190:1097–1104CrossRefPubMed
9.
Shortt CP, Gleeson TG, Breen KA et al (2009) Whole-body MRI versus PET in assessment of multiple myeloma disease activity. AJR Am J Roentgenol 192:980–986CrossRefPubMed
10.
Weininger M, Lauterbach B, Knop S et al (2009) Whole-body MRI of multiple myeloma: comparison of different MRI sequences in assessment of different growth patterns. Eur J Radiol 69:339–345CrossRefPubMed
11.
Ghanem N, Lohrmann C, Engelhardt M et al (2006) Whole-body MRI in the detection of bone marrow infiltration in patients with plasma cell neoplasms in comparison to the radiological skeletal survey. Eur Radiol 16:1005–1014CrossRefPubMed
12.
Zenge MO, Ladd ME, Quick HH (2009) Novel reconstruction method for three-dimensional axial continuously moving table whole-body magnetic resonance imaging featuring autocalibrated parallel imaging GRAPPA. Magn Reson Med 61:867–873CrossRefPubMed
13.
Kruger DG, Riederer SJ, Polzin JA, Madhuranthakam AJ, Hu HH, Glockner JF (2005) Dual-velocity continuously moving table acquisition for contrast-enhanced peripheral magnetic resonance angiography. Magn Reson Med 53:110–117CrossRefPubMed
14.
Kruger DG, Riederer SJ, Rossman PJ, Mostardi PM, Madhuranthakam AJ, Hu HH (2005) Recovery of phase inconsistencies in continuously moving table extended field of view magnetic resonance imaging acquisitions. Magn Reson Med 54:712–717CrossRefPubMed
15.
Zenge MO, Ladd ME, Vogt FM, Brauck K, Barkhausen J, Quick HH (2005) Whole-body magnetic resonance imaging featuring moving table continuous data acquisition with high-precision position feedback. Magn Reson Med 54:707–711CrossRefPubMed
16.
Fautz HP, Kannengiesser SA (2006) Sliding multislice (SMS): a new technique for minimum FOV usage in axial continuously moving-table acquisitions. Magn Reson Med 55:363–370CrossRefPubMed
17.
Aldefeld B, Bornert P, Keupp J (2006) Continuously moving table 3D MRI with lateral frequency-encoding direction. Magn Reson Med 55:1210–1216CrossRefPubMed
18.
Bornert P, Aldefeld B (2008) Principles of whole-body continuously-moving-table MRI. J Magn Reson Imaging 28:1–12CrossRefPubMed
19.
Kramer H, Zenge M, Schmitt P, Glaser C, Reiser MF, Herrmann KA (2008) Peripheral magnetic resonance angiography (MRA) with continuous table movement at 3.0T: initial experience compared with step-by-step MRA. Invest Radiol 43:627–634CrossRefPubMed
20.
Vogt FM, Zenge MO, Ladd ME et al (2007) Peripheral vascular disease: comparison of continuous MR angiography and conventional MR angiography-pilot study. Radiology 243:229–238CrossRefPubMed
21.
Zenge MO, Vogt FM, Brauck K et al (2006) High-resolution continuously acquired peripheral MR angiography featuring partial parallel imaging GRAPPA. Magn Reson Med 56:859–865CrossRefPubMed
22.
Kruger DG, Riederer SJ, Grimm RC, Rossman PJ (2002) Continuously moving table data acquisition method for long FOV contrast-enhanced MRA and whole-body MRI. Magn Reson Med 47:224–231CrossRefPubMed
23.
Brauck K, Zenge MO, Vogt FM et al (2008) Feasibility of whole-body MR with T2-and T1-weighted real-time steady-state free precession sequences during continuous table movement to depict metastases. Radiology 246:910–916CrossRefPubMed
24.
Baumann T, Ludwig U, Pache G et al (2009) Continuously moving table MRI with sliding multislice for rectal cancer staging: image quality and lesion detection. Eur J Radiol 73(3):579–587CrossRefPubMed
25.
Baumann T, Ludwig U, Pache G et al (2008) Detection of pulmonary nodules with move-during-scan magnetic resonance imaging using a free-breathing turbo inversion recovery magnitude sequence. Invest Radiol 43:359–367CrossRefPubMed
26.
Sommer G, Schaefer AO, Baumann T, Ludwig UA, Fautz HP (2008) Sliding multislice MRI for abdominal staging of patients with pelvic malignancies: a pilot study. J Magn Reson Imaging 27:666–672CrossRefPubMed
27.
Bley TA, Tittelbach-Helmrich D, Baumann T et al (2007) Sliding multislice MRI for abdominal staging of rectal gastrointestinal stromal tumours. In Vivo 21:891–894PubMed
28.
29.
Johnson KM, Leavitt GD, Kayser HW (1997) Total-body MR imaging in as little as 18 seconds. Radiology 202:262–267PubMed
30.
Ludwig U, Sommer G, Zaitsev M, Ghanem N, Hennig J, Fautz HP (2006) 2D axial moving table acquisitions with dynamic slice adaptation. Magn Reson Med 55:423–430CrossRefPubMed
31.
Daffner RH, Lupetin AR, Dash N, Deeb ZL, Sefczek RJ, Schapiro RL (1986) MRI in the detection of malignant infiltration of bone marrow. AJR Am J Roentgenol 146:353–358PubMed
32.
Dinter DJ, Neff WK, Klaus J et al (2008) Comparison of whole-body MR imaging and conventional X-ray examination in patients with multiple myeloma and implications for therapy. Ann Hematol 88:457–464CrossRefPubMed
33.
34.
35.
Kyle RA, Rajkumar SV (2009) Treatment of multiple myeloma: a comprehensive review. Clin Lymphoma Myeloma 9:278–288CrossRefPubMed
36.
Barkhausen J, Quick HH, Lauenstein T et al (2001) Whole-body MR imaging in 30 seconds with real-time true FISP and a continuously rolling table platform: feasibility study. Radiology 220:252–256PubMed
37.
Varettoni M, Corso A, Pica G, Mangiacavalli S, Pascutto C, Lazzarino M (2009) Incidence, presenting features and outcome of extramedullary disease in multiple myeloma: a longitudinal study on 1003 consecutive patients. Ann Oncol 21:325–330CrossRefPubMed
Metadata
Title
Comparison of a new whole-body continuous-table-movement protocol versus a standard whole-body MR protocol for the assessment of multiple myeloma
Authors
S. Weckbach
H. J. Michaely
A. Stemmer
S. O. Schoenberg
D. J. Dinter
Publication date
01-12-2010
Publisher
Springer-Verlag
Published in
European Radiology / Issue 12/2010
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-010-1865-9

Other articles of this Issue 12/2010

European Radiology 12/2010 Go to the issue

Interventional

Primary percutaneous aspiration and thrombolysis for the treatment of acute embolic superior mesenteric artery occlusion

Urogenital

Prospective comparison of T2w-MRI and dynamic-contrast-enhanced MRI, 3D-MR spectroscopic imaging or diffusion-weighted MRI in repeat TRUS-guided biopsies

Oncology

Early response assessment in patients with multiple myeloma during anti-angiogenic therapy using arterial spin labelling: first clinical results

Head and Neck

Regional impairment of 18F-FDG uptake in the cervical spinal cord in patients with monosegmental chronic cervical myelopathy

Interpretation Corner

Intratendinous ganglion of the long head of the biceps tendon: US and MRI features (2010: 9b)

Cardiac

Influence of statin treatment on coronary atherosclerosis visualised using multidetector computed tomography