Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
European Radiology
Published in: European Radiology 8/2010

01-08-2010 | Contrast Media

Evaluation of contrast-enhanced magnetic resonance angiography (MRA) using Gd-DOTA compared with time-of-flight MRA in the diagnosis of clinically significant non-coronary arterial disease

Authors: Joon-Won Kang, Tae-Hwan Lim, Choong-Gon Choi, Gi-Young Ko, Jeong-Kon Kim, Tae-Won Kwon

Published in: European Radiology | Issue 8/2010

Login to get access

Abstract

Objectives

This trial assessed diagnostic accuracy of contrast-enhanced magnetic resonance angiography (MRA) with meglumine gadoterate (Gd-DOTA) at 3 Tesla (T) over unenhanced MRA at 3 T in non-coronary arterial diseases by comparing their accuracy with that of the gold standard, x-ray angiography.

Methods

Ninety-two patients with suspected non-coronary arterial disease underwent in fixed sequence unenhanced time-of flight (TOF) MRA, contrast-enhanced MRA using a Gd-DOTA bolus (intravenous bolus 0.1 mmol/kg) and x-ray angiography.

Results

Eighty-four patients (71 male, 13 female; median age 64.5 years) were included in an intent-to-treat efficacy analysis. Targeted vascular areas were aorto-iliac, calf, carotid, femoral, popliteal and renal. Within-patient accuracy was significantly higher with contrast-enhanced MRA using Gd-DOTA than with unenhanced MRA (p = 0.0003). There was 84.4 ± 17.5% agreement between contrast-enhanced MRA (Gd-DOTA) and x-ray angiography, compared with 76.8 ± 20.4% between non-enhanced MRA and x-ray angiography. Sensitivity and specificity were also better with Gd-DOTA compared with non-enhanced MRA at the segment level. Duration of the MRA procedure was 3.5 times shorter with Gd-DOTA compared with non-enhanced MRA. Six patients reported six mild or moderate adverse events. No serious adverse events occurred.

Conclusions

Contrast-enhanced MRA using Gd-DOTA at 3 T was superior to unenhanced TOF MRA in the vascular territories investigated.
Literature
1.
Prince MR, Narasimham DL, Stanley JC, Chenevert TL, Williams DM, Marx MV, Cho KJ (1995) Breath-hold gadolinium-enhanced MR angiography of the abdominal aorta and its major branches. Radiology 197:785–792PubMed
2.
Allard M, Doucet D, Kien P, Bonnemain B, Caille JM (1988) Experimental study of DOTA-gadolinium. Invest Radiol 23(Suppl 1):S271–S274PubMed
3.
Herborn CU, Honold E, Wolf M, Kemper J, Kinner S, Adam G, Barkhausen J (2007) Clinical safety and diagnostic value of the gadolinium chelate gadoterate meglumine (Gd-DOTA). Invest Radiol 42:58–62CrossRefPubMed
4.
Brichaux JC, Grenier N, Douws C (1991) MR angiography of renal and pancreatic transplants arteries. 10th Annual Meeting of the Society of Magnetic Resonance in Medicine, San Francisco, p 140
5.
Loubeyre P, Revel D, Douek P, Delignette A, Baldy C, Genin G, Amiel M (1994) Dynamic contrast-enhanced MR angiography of pulmonary embolism: comparison with pulmonary angiography. AJR Am J Roentgenol 162:1035–1039PubMed
6.
Revel D, Loubeyre P, Delignette A, Douek P, Amiel M (1993) Contrast-enhanced magnetic resonance tomoangiography: a new imaging technique for studying thoracic great vessels. Magn Reson Imaging 11:1101–1105CrossRefPubMed
7.
Kelle S, Nagel E (2007) Cardiovascular MRI at 3 T. Eur Radiol 17(Suppl 6):F42–F47PubMed
8.
Habibi R, Krishnam MS, Lohan DG, Barkhordarian F, Jalili M, Saleh RS, Ruehm SG, Finn JP (2008) High-spatial-resolution lower extremity MR angiography at 3.0 T: contrast agent dose comparison study. Radiology 248:680–692CrossRefPubMed
9.
Kuhl CK, Träber F, Schild HH (2008) Whole-body high-field-strength (3.0-T) MR Imaging in Clinical Practice. Part I. Technical considerations and clinical applications. Radiology 246:675–696CrossRefPubMed
10.
11.
Fleiss JL (1973) Statistical methods for rates and proportions. John Wiley & Sons, New York
12.
Thurnher S, Miller S, Schneider G, Ballarati C, Bongartz G, Herborn CU, Schoenberg S, Cova MA, Morana G, Niazi K, Iezzi R, Taupitz M, Bluemke DA, Kreitner KF, Kirchin MA, Pirovano G (2007) Diagnostic performance of gadobenate dimeglumine-enhanced MR angiography of the iliofemoral and calf arteries: a large-scale multicentre trial. AJR Am J Roentgenol 189:1223–1237CrossRefPubMed
13.
Pereles FS, Collins JD, Carr JC, Francois C, Morasch MD, McCarthy RM, Krupinski EA, Butler GM, Finn JP (2006) Accuracy of stepping-table lower extremity MR angiography with dual-level bolus timing and separate calf acquisition: hybrid peripheral MR angiography. Radiology 240:283–290CrossRefPubMed
14.
D’Onofrio M, Mansueto G, Faccioli N, Guarise A, Tamellini P, Bogina G, Pozzi Mucelli R (2006) Doppler ultrasound and contrast-enhanced magnetic resonance angiography in assessing carotid artery stenosis. Radiol Med (Torino) 111:93–103CrossRef
15.
Yin D, Baum RA, Carpenter JP, Langlotz CP, Pentecost MJ (1995) Cost-effectiveness of MR angiography in cases of limb-threatening peripheral vascular disease. Radiology 194:757–764PubMed
16.
Nelemans PJ, Leiner T, de Vet HCW, van Engelshoven JM (2000) Peripheral arterial disease: meta-analysis of the diagnostic performance of MR angiography. Radiology 217:105–114PubMed
17.
Wardlaw JM, Chappell FM, Best JJ, Wartolowska K, Berry E, NHS Research and Development Health Technology Assessment Carotid Stenosis Imaging Group (2006) Non-invasive imaging compared with intra-arterial angiography in the diagnosis of symptomatic carotid stenosis: a meta-analysis. Lancet 367:1503–1512CrossRefPubMed
18.
Kwee TC, Kwee RM (2007) MR angiography in the follow-up of intracranial aneurysms treated with Guglielmi detachable coils: a systematic review and meta-analysis. Neuroradiology. 49:703–713CrossRefPubMed
19.
Lin W, An H, Chen Y, Nicholas P, Zhai G, Gerig G, Gilmore J, Bullitt E (2003) Practical consideration for 3T imaging. Magn Reson Imaging Clin N Am 11:615–639CrossRefPubMed
20.
Ganguli S, Pedrosa I, Smith MP, Niendorf ER, Fredericks S, Rofsky NM (2008) Low dose pedal magnetic resonance angiography at 3 Tesla with time-resolved imaging of contrast kinetics. A feasibility study. Invest Radiol 43:650–655
21.
Collins R, Cranny G, Burch J, Aguiar-Ibanez R, Craig D, Wright K, Berry E, Gough M, Kleijnen J, Westwood M (2007) A systematic review of duplex ultrasound, magnetic resonance angiography and computed tomography angiography for the diagnosis and assessment of symptomatic lower limb peripheral arterial disease. Health Technol Assess 11(20):1–184 iii–iv, xi–xiii
22.
Michaely HJ, Kramer H, Attenberger U, Sourbron SP, Weckbach S, Reiser MF, Schoenberg SO (2007) Renal magnetic resonance angiography at 3.0 T: technical feasibility and clinical perspectives. Top Magn Reson Imaging 18:117–125CrossRefPubMed
23.
Michaely HJ, Attenberger UI, Kramer H, Nael K, Reiser MF, Schoenberg SO (2007) Abdominal and pelvic MR angiography. Magn Reson Imaging Clin N Am 15:301–314CrossRefPubMed
24.
Hansen T, Ahlström H, Wikström J, Lind K, Johansson L (2008) A total atherosclerotic score for whole-body MRA and its relation to traditional cardiovascular risk factors. Eur Radiol 18:1174–1180CrossRefPubMed
25.
Tombach B, Bohndorf K, Brodtrager W, Claussen CD, Düber C, Galanski M, Grabbe E, Gortenuti G, Kuhn M, Gross-Fengels W, Hammerstingl R, Happel B, Heinz-Peer G, Jung G, Kittner T, Lagalla R, Lengsfeld P, Loose R, Oyen RHG, Pavlici P, Pering C, Pozzi-Mucelli R, Persigehl T, Reimer P, Renken NS, Richter GM, Rummeny EJ, Schäfer F, Szczerbo-Trojanowska M, Urbanik A, Vogl TJ, Hajek P (2008) Comparison of 1.0 M gadobutrol and 0.5 M gadopentate dimeglumine-enhanced MRI in 471 patients with known or suspected renal lesions: results of a multicenter, single-blind, interindividual, randomized clinical phase III trial. Eur Radiol 18:2610–2619CrossRefPubMed
Metadata
Title
Evaluation of contrast-enhanced magnetic resonance angiography (MRA) using Gd-DOTA compared with time-of-flight MRA in the diagnosis of clinically significant non-coronary arterial disease
Authors
Joon-Won Kang
Tae-Hwan Lim
Choong-Gon Choi
Gi-Young Ko
Jeong-Kon Kim
Tae-Won Kwon
Publication date
01-08-2010
Publisher
Springer-Verlag
Published in
European Radiology / Issue 8/2010
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-010-1764-0

Other articles of this Issue 8/2010

European Radiology 8/2010 Go to the issue

Magnetic Resonance

Whole-body diffusion-weighted magnetic resonance imaging with apparent diffusion coefficient mapping for staging patients with diffuse large B-cell lymphoma

Chest

Diffuse interstitial lung disease: overlaps and uncertainties

Urogenital

A new computer-aided diagnostic tool for non-invasive characterisation of malignant ovarian masses: results of a multicentre validation study

Contrast Media

Biphasic contrast medium injection in cardiac CT: moderate versus high concentration contrast material at identical iodine flux and iodine dose

Interventional

Treatment of carotid siphon aneurysms by use of the Willis stent graft: an angiographic and histopathological study

Ultrasound

Real-time contrast-enhanced ultrasound-guided biopsy of focal hepatic lesions not localised on B-mode ultrasound