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01-04-2010 | Pediatric

Assessment of lung development in isolated congenital diaphragmatic hernia using signal intensity ratios on fetal MR imaging

Authors: Csilla Balassy, Gregor Kasprian, Peter C. Brugger, Michael Weber, Bence Csapo, Christian Herold, Daniela Prayer

Published in: European Radiology | Issue 4/2010

Abstract

Objectives

To investigate developmental changes in the apparently unaffected contralateral lung by using signal intensity ratios (SIR) and lung volumes (LV), and to search for correlation with clinical outcome.

Methods

Twenty-five fetuses (22–37 weeks’ gestation) were examined. Lung/liver signal intensity ratios (LLSIR) were assessed on T1-weighted and T2-weighted sequences for both lungs, then together with LV compared with age-matched controls of 91 fetuses by using the U test. Differences in LLSIRs and lung volumes were correlated with neonatal outcomes.

Results

LLSIRs in fetuses with congenital diaphragmatic hernia (CDH) were significantly higher in both lungs on T1-weighted images and significantly lower on T2-weighted images, compared with normals (p < 0.05), increasing on T2-weighted imaging and decreasing on T1-weighted imaging during gestation. Total LV were significantly smaller in the CDH group than in controls (p < 0.05). No significant differences in LLSIR of the two lungs were found. Outcomes correlated significantly with total LV, but not with LLSIR.

Conclusion

Changes in LLSIR seem to reflect developmental impairment in CDH; however, they provide no additional information in predicting outcome. LV remains the best indicator on fetal MR imaging of neonatal survival in isolated, left-sided CDH.

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Title: Assessment of lung development in isolated congenital diaphragmatic hernia using signal intensity ratios on fetal MR imaging
Authors: Csilla Balassy
Gregor Kasprian
Peter C. Brugger
Michael Weber
Bence Csapo
Christian Herold
Daniela Prayer
Publication date: 01-04-2010
Publisher: Springer-Verlag
Published in: European Radiology / Issue 4/2010
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-009-1633-x

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Assessment of lung development in isolated congenital diaphragmatic hernia using signal intensity ratios on fetal MR imaging

Abstract

Objectives

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusion

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