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01-03-2010 | Cardiac

High resolution myocardial magnetic resonance stress perfusion imaging at 3 T using a 1 M contrast agent

Authors: Bernhard D. Klumpp, Achim Seeger, Christina Doesch, Joerg Doering, Tobias Hoevelborn, Ulrich Kramer, Michael Fenchel, Meinrad P. Gawaz, Claus D. Claussen, Stephan Miller

Published in: European Radiology | Issue 3/2010

Abstract

Objective

Stress perfusion magnetic resonance imaging (MSPMRI) is an established technique for the assessment of myocardial perfusion. Shortcomings at 1.5 T are low signal to noise ratio (SNR) and contrast to noise ratio (CNR). One approach to overcome these shortcomings is to increase field strength and contrast concentration. The aim of our study was to investigate the diagnostic capability of high resolution MSPMRI at 3-T field strength using a 1 M contrast agent.

Material and methods

Fifty-seven patients (62.3 ± 11.0 years) with symptoms of coronary artery disease (CAD) were examined at 3 T. MMRSPI was assessed using a 2D saturation recovery gradient echo (SR GRE) sequence in short axis orientation (TR 1.9 ms, TE 1.0 ms, flip 12°, 0.1 mmol gadobutrol/kg body weight (bw), 140 µg adenosine/kg bw/min). Perfusion images were assessed visually and semiquantitatively (upslope, peak signal intensity (SI), and myocardial perfusion reserve index (MPRI)). Standard of reference was invasive coronary angiography.

Results

Stress-induced hypoperfusion was found in 43 patients. Sensitivity for hemodynamically relevant CAD (stenoses greater than 70%) was 95%/98%, specificity 80%/87%, diagnostic accuracy 91%/95% (reader 1/reader 2). The MPRI was significantly lower in hypoperfused myocardium (1.3 ± 0.2) compared with normal myocardium (2.6 ± 0.7).

Conclusion

High resolution MMRSPI at 3 T using 1 M contrast agent under daily routine conditions provides reliable detection of stress-induced myocardial hypoperfusion with higher diagnostic accuracy than 1.5-T conditions.

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Title: High resolution myocardial magnetic resonance stress perfusion imaging at 3 T using a 1 M contrast agent
Authors: Bernhard D. Klumpp
Achim Seeger
Christina Doesch
Joerg Doering
Tobias Hoevelborn
Ulrich Kramer
Michael Fenchel
Meinrad P. Gawaz
Claus D. Claussen
Stephan Miller
Publication date: 01-03-2010
Publisher: Springer-Verlag
Published in: European Radiology / Issue 3/2010
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-009-1580-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

High resolution myocardial magnetic resonance stress perfusion imaging at 3 T using a 1 M contrast agent

Abstract

Objective

Material and methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Material and methods

Results

Conclusion

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