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01-11-2009 | Chest

Suppression of pulmonary vasculature in lung perfusion MRI using correlation analysis

Authors: Frank Risse, Tristan A. Kuder, Hans-Ulrich Kauczor, Wolfhard Semmler, Christian Fink

Published in: European Radiology | Issue 11/2009

Abstract

The purpose of the study was to evaluate the feasibility of suppressing the pulmonary vasculature in lung perfusion MRI using cross-correlation analysis (CCA). Perfusion magnetic resonance imaging (MRI) (3D FLASH, TR/TE/flip angle: 0.8 ms/2.1 ms/40°) of the lungs was performed in seven healthy volunteers at 1.5 Tesla after injection of Gd-DTPA. CCA was performed pixel-wise in lung segmentations using the signal time-course of the main pulmonary artery and left atrium as references. Pixels with high correlation coefficients were considered as arterial or venous and excluded from further analysis. Quantitative perfusion parameters [pulmonary blood flow (PBF) and volume (PBV)] were calculated for manual lung segmentations separately, with the entire left and right lung with all intrapulmonary vessels (IPV) included, excluded manually or excluded using CCA. The application of CCA allowed reliable suppression of hilar and large IPVs. Using vascular suppression by CCA, perfusion parameters were significantly reduced (p ≤ 0.001). The reduction was 8% for PBF and 13% for PBV compared with manual exclusion and 15% for PBF and 25% for PBV when all vessel structures were included. The application of CCA improves the visualisation and quantification of lung perfusion in MRI. Overestimation of perfusion parameters caused by pulmonary vessels is significantly reduced.

Reinartz P, Wildberger JE, Schaefer W, Nowak B, Mahnken AH, Buell U (2004) Tomographic imaging in the diagnosis of pulmonary embolism: a comparison between V/Q lung scintigraphy in SPECT technique and multislice spiral CT. J Nucl Med 45:1501–1508PubMed

Fazio F, Wollmer P (1981) Clinical ventilation-perfusion scintigraphy. Clin Physiol 1:323–337CrossRefPubMed

Fink C, Bock M, Puderbach M, Schmahl A, Delorme S (2003) Partially parallel three-dimensional magnetic resonance imaging for the assessment of lung perfusion—initial results. Invest Radiol 38:482–488CrossRefPubMed

Hatabu H, Gaa J, Kim D, Li W, Prasad PV, Edelman RR (1996) Pulmonary perfusion: qualitative assessment with dynamic contrast-enhanced MRI using ultra-short TE and inversion recovery turbo FLASH. Magn Reson Med 36:503–508CrossRefPubMed

Ohno Y, Hatabu H, Murase K et al (2004) Quantitative assessment of regional pulmonary perfusion in the entire lung using three-dimensional ultrafast dynamic contrast-enhanced magnetic resonance imaging: preliminary experience in 40 subjects. J Magn Reson Imaging 20:353–365CrossRefPubMed

Kluge A, Gerriets T, Lange U, Bachman G (2005) MRI for short-term follow-up of acute pulmonary embolism. Assessment of thrombus appearance and pulmonary perfusion: a feasibility study. Eur Radiol 15:1969–1977CrossRefPubMed

Fink C, Risse F, Buhmann R et al (2004) Quantitative analysis of pulmonary perfusion using time-resolved parallel 3D MRI—initial results. Rofo 176:170–174PubMed

Fink C, Puderbach M, Bock M et al (2004) Regional lung perfusion: assessment with partially parallel three-dimensional MR imaging. Radiology 231:175–184CrossRefPubMed

Nikolaou K, Schoenberg SO, Attenberger U et al (2005) Pulmonary arterial hypertension: diagnosis with fast perfusion MR imaging and high-spatial-resolution MR angiography—preliminary experience. Radiology 236:694–703CrossRefPubMed

10.

Dehnert C, Risse F, Ley S et al (2006) Magnetic resonance imaging of uneven pulmonary perfusion in hypoxia in humans. Am J Respir Crit Care Med 174:1132–8CrossRefPubMed

11.

Fink C, Ley S, Risse F et al (2005) Effect of inspiratory and expiratory breathhold on pulmonary perfusion: assessment by pulmonary perfusion magnetic resonance imaging. Invest Radiol 40:72–79CrossRefPubMed

12.

Meier P, Zierler KL (1954) On the theory of the indicator-dilution method for measurement of blood flow and volume. J Appl Physiol 6:731–744PubMed

13.

Nikolaou K, Schoenberg SO, Brix G et al (2004) Quantification of pulmonary blood flow and volume in healthy volunteers by dynamic contrast-enhanced magnetic resonance imaging using a parallel imaging technique. Invest Radiol 39:537–545CrossRefPubMed

14.

Schuster DP, Kaplan JD, Gauvain K, Welch MJ, Markham J (1995) Measurement of regional pulmonary blood flow with PET. J Nucl Med 36:371–377PubMed

15.

Levin DL, Chen Q, Zhang M, Edelman RR, Hatabu H (2001) Evaluation of regional pulmonary perfusion using ultrafast magnetic resonance imaging. Magn Reson Med 46:166–171CrossRefPubMed

16.

Bock M, Schoenberg SO, Floemer F, Schad LR (2000) Separation of arteries and veins in 3D MR angiography using correlation analysis. Magn Reson Med 43:481–487CrossRefPubMed

17.

Santini F, Patil S, Meckel S, Scheffler K, Wetzel SG (2008) Double-reference cross-correlation algorithm for separation of the arteries and veins from 3D MRA time series. J Magn Reson Imaging 28:646–654CrossRefPubMed

18.

Bandettini PA, Jesmanowicz A, Wong EC, Hyde JS (1993) Processing strategies for time-course data sets in functional MRI of the human brain. Magn Reson Med 30:161–173CrossRefPubMed

19.

Weisskoff RM, Chesler D, Boxerman JL, Rosen BR (1993) Pitfalls in MR measurement of tissue blood flow with intravascular tracers: which mean transit time? Magn Reson Med 29:553–558CrossRefPubMed

20.

Hatabu H, Tadamura E, Levin DL et al (1999) Quantitative assessment of pulmonary perfusion with dynamic contrast-enhanced MRI. Magn Reson Med 42:1033–1038CrossRefPubMed

Title: Suppression of pulmonary vasculature in lung perfusion MRI using correlation analysis
Authors: Frank Risse
Tristan A. Kuder
Hans-Ulrich Kauczor
Wolfhard Semmler
Christian Fink
Publication date: 01-11-2009
Publisher: Springer-Verlag
Published in: European Radiology / Issue 11/2009
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-009-1464-9

At a glance: The STEP trials

Springer Medicine

Suppression of pulmonary vasculature in lung perfusion MRI using correlation analysis

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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