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Published in: European Radiology 8/2009

01-08-2009 | Musculoskeletal

Quantitative ultrasound in the assessment of skeletal status

Authors: Giuseppe Guglielmi, Judith Adams, Thomas M. Link

Published in: European Radiology | Issue 8/2009

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Abstract

Quantitative ultrasound (QUS) is a non-invasive technique for the investigation of bone tissue in several pathologies and clinical conditions, especially in the field of osteoporosis. The versatility of the technique, its low cost and lack of ionising radiation have led to the diffusion of this method worldwide. Several studies have been conducted in the last years to investigate the potential of QUS in multiple areas with promising results; the technique has been applied in the prediction of osteoporotic fractures, in monitoring therapies, in the investigation of secondary osteoporosis, in paediatrics, neonatology and genetics. Our review article gives an overview of the most relevant developments in the field of quantitative ultrasound, both in clinical and in experimental settings.
Literature
1.
go back to reference Seeman E (2008) Bone quality: the material and structural basis of bone strength. J Bone Miner Metab 26:1–8PubMedCrossRef Seeman E (2008) Bone quality: the material and structural basis of bone strength. J Bone Miner Metab 26:1–8PubMedCrossRef
2.
3.
go back to reference Nguyen TV, Blangero J, Eisman JA (2000) Genetic epidemiological approaches to the search for osteoporosis genes. J Bone Miner Res 15:392–401PubMedCrossRef Nguyen TV, Blangero J, Eisman JA (2000) Genetic epidemiological approaches to the search for osteoporosis genes. J Bone Miner Res 15:392–401PubMedCrossRef
4.
go back to reference Baroncelli GI, Federico G, Vignolo M et al (2006) Cross-sectional reference data for phalangeal quantitative ultrasound from early childhood to young-adulthood according to gender, age, skeletal growth, and pubertal development. Bone 39:159–173PubMedCrossRef Baroncelli GI, Federico G, Vignolo M et al (2006) Cross-sectional reference data for phalangeal quantitative ultrasound from early childhood to young-adulthood according to gender, age, skeletal growth, and pubertal development. Bone 39:159–173PubMedCrossRef
5.
go back to reference Baroncelli GI, Federico G, Bertelloni S et al (2003) Assessment of bone quality by quantitative ultrasound of proximal phalangeas of the hand and fracture rate in children and adolescents with bone and mineral disorders. Pediatr Res 54:125–136PubMedCrossRef Baroncelli GI, Federico G, Bertelloni S et al (2003) Assessment of bone quality by quantitative ultrasound of proximal phalangeas of the hand and fracture rate in children and adolescents with bone and mineral disorders. Pediatr Res 54:125–136PubMedCrossRef
6.
go back to reference Baroncelli GI (2008) Quantitative ultrasound methods to assess bone mineral status in children: technical characteristics, performance, and clinical application. Pediatr Res 63:220–228PubMedCrossRef Baroncelli GI (2008) Quantitative ultrasound methods to assess bone mineral status in children: technical characteristics, performance, and clinical application. Pediatr Res 63:220–228PubMedCrossRef
7.
go back to reference McDevitt H, Ahmed SF (2007) Quantitative Ultrasound Assessment of Bone Health in the Neonate. Neonatology 91:2–11PubMedCrossRef McDevitt H, Ahmed SF (2007) Quantitative Ultrasound Assessment of Bone Health in the Neonate. Neonatology 91:2–11PubMedCrossRef
8.
go back to reference Ferretti JL, Frost HM, Gasser JA et al (1995) Perspectives: on osteoporosis research: its focus and some insight of a new paradigm. Calcif Tissue Int 57:399–404PubMedCrossRef Ferretti JL, Frost HM, Gasser JA et al (1995) Perspectives: on osteoporosis research: its focus and some insight of a new paradigm. Calcif Tissue Int 57:399–404PubMedCrossRef
10.
go back to reference Barkmann R, Kantorovich E, Singal C et al (2000) A new method for quantitative ultrasound measurements at multiple skeletal sites: first results of precision and fracture discrimination. J Clin Densitom 3:1–7PubMedCrossRef Barkmann R, Kantorovich E, Singal C et al (2000) A new method for quantitative ultrasound measurements at multiple skeletal sites: first results of precision and fracture discrimination. J Clin Densitom 3:1–7PubMedCrossRef
11.
go back to reference Njeh CF, Hans D, Fuerst T, Gluer CC, Genant HK (1999) Quantitative ultrasound. Assessment of osteoporosis and bone status. Martin Dunitz Ltd ed., London UK Njeh CF, Hans D, Fuerst T, Gluer CC, Genant HK (1999) Quantitative ultrasound. Assessment of osteoporosis and bone status. Martin Dunitz Ltd ed., London UK
12.
go back to reference Lum CK, Wang MC, Moore E et al (1999) A comparison of calcaneus ultrasound and dual X-ray absorptiometry in healthy North American youths and young adults. J Clin Densitom 2:403–41PubMedCrossRef Lum CK, Wang MC, Moore E et al (1999) A comparison of calcaneus ultrasound and dual X-ray absorptiometry in healthy North American youths and young adults. J Clin Densitom 2:403–41PubMedCrossRef
13.
go back to reference Cadossi R, Canè V (1996) Pathways of transmission of ultrasound energy through the distal metaphysis of the second phalanx of pigs: an in vitro study. Osteoporos Int 6:196–206PubMedCrossRef Cadossi R, Canè V (1996) Pathways of transmission of ultrasound energy through the distal metaphysis of the second phalanx of pigs: an in vitro study. Osteoporos Int 6:196–206PubMedCrossRef
14.
go back to reference Wuster C, Albanese C, De Aloysio D et al (2000) Phalangeal osteosonogrammetry study: age-related changes, diagnostic sensitivity, and discrimination power. The Phalangeal Osteosonogrammetry Study Group. J Bone Miner Res 15:1603–1614PubMedCrossRef Wuster C, Albanese C, De Aloysio D et al (2000) Phalangeal osteosonogrammetry study: age-related changes, diagnostic sensitivity, and discrimination power. The Phalangeal Osteosonogrammetry Study Group. J Bone Miner Res 15:1603–1614PubMedCrossRef
15.
go back to reference Adami S, Giannini S, Giorgino R et al (2003) The effect of age, weight, and lifestyle factors on calcaneal quantitative ultrasound: the ESOPO study. Osteoporos Int 14:198–207PubMed Adami S, Giannini S, Giorgino R et al (2003) The effect of age, weight, and lifestyle factors on calcaneal quantitative ultrasound: the ESOPO study. Osteoporos Int 14:198–207PubMed
16.
go back to reference Hans D, Dargent-Molina P, Schott AM et al (1996) Ultrasonographic heel measurements to predict hip fracture in elderly women: the EPIDOS prospective study. Lancet 348:511–514PubMedCrossRef Hans D, Dargent-Molina P, Schott AM et al (1996) Ultrasonographic heel measurements to predict hip fracture in elderly women: the EPIDOS prospective study. Lancet 348:511–514PubMedCrossRef
17.
go back to reference Bauer DC, Gluer CC, Cauley JA et al (1997) Broadband ultrasound attenuation predict fractures strongly and independently of densitometry in older women. A prospective study. Arch Intern Med 157:629–634PubMedCrossRef Bauer DC, Gluer CC, Cauley JA et al (1997) Broadband ultrasound attenuation predict fractures strongly and independently of densitometry in older women. A prospective study. Arch Intern Med 157:629–634PubMedCrossRef
18.
go back to reference Krieg MA, Cornuz J, Ruffieux C et al (2006) Prediction of hip fracture risk by quantitative ultrasound in more than 7000 Swiss women > or = 70 years of age: comparison of three technologically different bone ultrasound devices in the SEMOF study. J Bone Miner Res 21:1457–1463PubMedCrossRef Krieg MA, Cornuz J, Ruffieux C et al (2006) Prediction of hip fracture risk by quantitative ultrasound in more than 7000 Swiss women > or = 70 years of age: comparison of three technologically different bone ultrasound devices in the SEMOF study. J Bone Miner Res 21:1457–1463PubMedCrossRef
19.
go back to reference Khaw KT, Reeve J, Luben R et al (2004) Prediction of total and hip fracture risk in men and women by quantitative ultrasound of the calcaneus: EPIC-Norfolk prospective population study. Lancet 363:197–202PubMedCrossRef Khaw KT, Reeve J, Luben R et al (2004) Prediction of total and hip fracture risk in men and women by quantitative ultrasound of the calcaneus: EPIC-Norfolk prospective population study. Lancet 363:197–202PubMedCrossRef
20.
go back to reference Guglielmi G, Cammisa M, De Serio A et al (1999) Phalangeal US velocity discriminates between normal and vertebrally fractured subjects. Eur Radiol 9:1632–1637PubMedCrossRef Guglielmi G, Cammisa M, De Serio A et al (1999) Phalangeal US velocity discriminates between normal and vertebrally fractured subjects. Eur Radiol 9:1632–1637PubMedCrossRef
21.
go back to reference Guglielmi G, Njeh CF, de Terlizzi F et al (2003) Palangeal quantitative ultrasound, phalangeal morphometric variables, and vertebral fracture discrimination. Calcif Tissue Int 72:469–77PubMedCrossRef Guglielmi G, Njeh CF, de Terlizzi F et al (2003) Palangeal quantitative ultrasound, phalangeal morphometric variables, and vertebral fracture discrimination. Calcif Tissue Int 72:469–77PubMedCrossRef
22.
go back to reference Hartl F, Tyndall A, Kraenzlin M et al (2002) Discriminatory ability of quantitative ultrasound parameters and bone mineral density in a population-based sample of postmenopausal women with vertebral fractures: result of the Basel Osteoporosis Study. J Bone Miner Res 17:321–330PubMedCrossRef Hartl F, Tyndall A, Kraenzlin M et al (2002) Discriminatory ability of quantitative ultrasound parameters and bone mineral density in a population-based sample of postmenopausal women with vertebral fractures: result of the Basel Osteoporosis Study. J Bone Miner Res 17:321–330PubMedCrossRef
23.
go back to reference Krieg MA, Cornuz J, Ruffieux C et al (2003) Comparison of three bone ultrasounds for the discrimination of subjects with and without osteoporotic fractures among 7562 elderly women. J Bone Miner Res 18:1261–1266PubMedCrossRef Krieg MA, Cornuz J, Ruffieux C et al (2003) Comparison of three bone ultrasounds for the discrimination of subjects with and without osteoporotic fractures among 7562 elderly women. J Bone Miner Res 18:1261–1266PubMedCrossRef
24.
go back to reference Camozzi V, De Terlizzi F, Zangari M, Luisetto G (2007) Quantitative bone ultrasound at phalanges and calcaneus in osteoporotic postmenopausal women: influence of age and measurement site. Ultrasound Med Biol 33:1039–1045PubMedCrossRef Camozzi V, De Terlizzi F, Zangari M, Luisetto G (2007) Quantitative bone ultrasound at phalanges and calcaneus in osteoporotic postmenopausal women: influence of age and measurement site. Ultrasound Med Biol 33:1039–1045PubMedCrossRef
25.
27.
go back to reference Gluer CC, Eastell R, Reid DM et al (2004) Association of five quantitative ultrasound devices and bone densitometry with osteoporotic vertebral fractures in a population-based sample: the OPUS study. J Bone Miner Res 19:782–793PubMedCrossRef Gluer CC, Eastell R, Reid DM et al (2004) Association of five quantitative ultrasound devices and bone densitometry with osteoporotic vertebral fractures in a population-based sample: the OPUS study. J Bone Miner Res 19:782–793PubMedCrossRef
28.
go back to reference Krieg MA, Hans D, Gonnelli S et al (2008) Quantitative ultrasound in the management of osteoporosis: the 2007 ISCD official positions. J Clin Densitom 11:163–187PubMedCrossRef Krieg MA, Hans D, Gonnelli S et al (2008) Quantitative ultrasound in the management of osteoporosis: the 2007 ISCD official positions. J Clin Densitom 11:163–187PubMedCrossRef
29.
go back to reference Hans D, Krieg M-A (2008) The clinical use of quantitative ultrasound (QUS) in the detection and management of osteoporosis. IEEE Trans Ultrason Ferroelectr Freq Control 55(7):1529–1538PubMedCrossRef Hans D, Krieg M-A (2008) The clinical use of quantitative ultrasound (QUS) in the detection and management of osteoporosis. IEEE Trans Ultrason Ferroelectr Freq Control 55(7):1529–1538PubMedCrossRef
30.
go back to reference Tauchmanova L, Rossi R, Nuzzo V et al (2001) Bone loss determined by quantitative ultrasonometry correlates inversely with disease activity in patients with endogenous glucocorticoid excess due to adrenal mass. Eur J Endocrinol 145:241–247PubMedCrossRef Tauchmanova L, Rossi R, Nuzzo V et al (2001) Bone loss determined by quantitative ultrasonometry correlates inversely with disease activity in patients with endogenous glucocorticoid excess due to adrenal mass. Eur J Endocrinol 145:241–247PubMedCrossRef
31.
go back to reference Roben P, Barkmann R, Ullrich S, Gause A, Heller M, Glüer C-C (2001) Assessment of phalangeal bone loss and erosions in patients with rheumatoid arthritis by quantitative ultrasound. Ann Rheum Dis 60:670–677PubMedCrossRef Roben P, Barkmann R, Ullrich S, Gause A, Heller M, Glüer C-C (2001) Assessment of phalangeal bone loss and erosions in patients with rheumatoid arthritis by quantitative ultrasound. Ann Rheum Dis 60:670–677PubMedCrossRef
32.
go back to reference Birkett V, Ring EFJ, Elvins DM, Taylor G, Bhalla AK (2003) A comparison of bone loss in early and late rheumatoid arthritis using quantitative phalangeal ultrasound. Clin Rheumatol 22:203–207PubMedCrossRef Birkett V, Ring EFJ, Elvins DM, Taylor G, Bhalla AK (2003) A comparison of bone loss in early and late rheumatoid arthritis using quantitative phalangeal ultrasound. Clin Rheumatol 22:203–207PubMedCrossRef
33.
go back to reference Luisetto G, Camozzi V, de Terlizzi F (2000) Use of quantitative ultrasonography in differentiating osteomalacia from osteoporosis: preliminary study. J Ultrasound Med 19:251–256PubMed Luisetto G, Camozzi V, de Terlizzi F (2000) Use of quantitative ultrasonography in differentiating osteomalacia from osteoporosis: preliminary study. J Ultrasound Med 19:251–256PubMed
34.
go back to reference Filosa A, de Terlizzi F (2002) Quantitative ultrasound (QUS): a new approach to evacuate bone status in thalassemic patients. Ital J Pediatr 28:310–318 Filosa A, de Terlizzi F (2002) Quantitative ultrasound (QUS): a new approach to evacuate bone status in thalassemic patients. Ital J Pediatr 28:310–318
35.
go back to reference Cepollaro C, Gonnelli S, Pondrelli C et al (1999) Osteogenesis Imperfecta: bone turnover, bone density, and ultrasound parameters. Calcif Tissue Int 65:129–132PubMedCrossRef Cepollaro C, Gonnelli S, Pondrelli C et al (1999) Osteogenesis Imperfecta: bone turnover, bone density, and ultrasound parameters. Calcif Tissue Int 65:129–132PubMedCrossRef
36.
go back to reference Gonnelli S, Montagnani A, Cepollaro C et al (2000) Quantitative ultrasound and bone mineral density in patients with primary hyperparathyroidism before and after surgical treatment. Osteoporos Int 11:255–260PubMedCrossRef Gonnelli S, Montagnani A, Cepollaro C et al (2000) Quantitative ultrasound and bone mineral density in patients with primary hyperparathyroidism before and after surgical treatment. Osteoporos Int 11:255–260PubMedCrossRef
37.
go back to reference Taccari E, Sensi F, Spadaro A, Riccieri V, Rinaldi T (2001) Ultrasound measurements at the proximal phalanges in male patients with psoriatic arthritis. Osteoporos Int 12:412–416PubMedCrossRef Taccari E, Sensi F, Spadaro A, Riccieri V, Rinaldi T (2001) Ultrasound measurements at the proximal phalanges in male patients with psoriatic arthritis. Osteoporos Int 12:412–416PubMedCrossRef
38.
go back to reference Pluskiewicz W, Nowakowska J (1997) Bone status after long-term anticonvulsant therapy in epileptic patients: evaluation using quantitative ultrasound of calcaneus and phalanxes. Ultrasound Med Biol 23:553–558PubMedCrossRef Pluskiewicz W, Nowakowska J (1997) Bone status after long-term anticonvulsant therapy in epileptic patients: evaluation using quantitative ultrasound of calcaneus and phalanxes. Ultrasound Med Biol 23:553–558PubMedCrossRef
39.
go back to reference Rossini M, Viapiana O, Del Marco A, de Terlizzi F, Gatti D, Adami S (2007) Quantitative ultrasound in adults with cystic fibrosis: correlation with bone mineral density and risk of vertebral fractures. Calcif Tissue Int 80:44–49PubMedCrossRef Rossini M, Viapiana O, Del Marco A, de Terlizzi F, Gatti D, Adami S (2007) Quantitative ultrasound in adults with cystic fibrosis: correlation with bone mineral density and risk of vertebral fractures. Calcif Tissue Int 80:44–49PubMedCrossRef
40.
go back to reference Montagnani A, Gonnelli S, Cepollaro C (1999) Quantitative Ultrasound in the Assessment of Skeletal Status in Uremic Patients. J Clin Densitom 2:389–395PubMedCrossRef Montagnani A, Gonnelli S, Cepollaro C (1999) Quantitative Ultrasound in the Assessment of Skeletal Status in Uremic Patients. J Clin Densitom 2:389–395PubMedCrossRef
41.
go back to reference Rico H, Aguado F, Revilla M et al (1999) Ultrasound bone velocity and metacarpal radiogrammetry in hemodialyzed patients. Miner Electrolyte Metab 20:103–106 Rico H, Aguado F, Revilla M et al (1999) Ultrasound bone velocity and metacarpal radiogrammetry in hemodialyzed patients. Miner Electrolyte Metab 20:103–106
42.
go back to reference Przedlacki J, Pluskiewicz W, Wieliczko M et al (1999) Quantitative Ultrasound of phalanges and Dual-Energy X-ray Absorptiometry of forearm and hand in patients with end-stage renal failure treated with dialysis. Osteoporos Int 10:1–6PubMedCrossRef Przedlacki J, Pluskiewicz W, Wieliczko M et al (1999) Quantitative Ultrasound of phalanges and Dual-Energy X-ray Absorptiometry of forearm and hand in patients with end-stage renal failure treated with dialysis. Osteoporos Int 10:1–6PubMedCrossRef
43.
go back to reference Pluskiewicz W, Adamczyk P, Drozdzowska B et al (2002) Skeletal status in children, adolescents and young adults with end-stage renal failure treated with hemo- or peritoneal dialysis. Osteoporos Int 13:353–357PubMedCrossRef Pluskiewicz W, Adamczyk P, Drozdzowska B et al (2002) Skeletal status in children, adolescents and young adults with end-stage renal failure treated with hemo- or peritoneal dialysis. Osteoporos Int 13:353–357PubMedCrossRef
44.
go back to reference Pluskiewicz W, Adamczyk P, Drozdzowska B (2003) Skeletal status in children and adolescents with chronic renal failure before onset of dialysis or on dialysis. Osteoporos Int 14:283–288PubMedCrossRef Pluskiewicz W, Adamczyk P, Drozdzowska B (2003) Skeletal status in children and adolescents with chronic renal failure before onset of dialysis or on dialysis. Osteoporos Int 14:283–288PubMedCrossRef
45.
go back to reference Pluskiewicz W, Zwiec J, Gumprecht J, Grzeszczak W (2007) Quantitative ultrasound of phalanges of adults with end-stage renal disease or who have undergone renal transplantation. Ultrasound Med Biol 33:1353–61PubMedCrossRef Pluskiewicz W, Zwiec J, Gumprecht J, Grzeszczak W (2007) Quantitative ultrasound of phalanges of adults with end-stage renal disease or who have undergone renal transplantation. Ultrasound Med Biol 33:1353–61PubMedCrossRef
46.
go back to reference Taal MW, Cassidy MJD, Pearson D, Green D, Masud T (1999) Usefulness of quantitative heel ultrasound compared with dual-energy X-ray absorptiometry in determining bone mineral density in chronic haemodialysis patients. Nephrol Dial Transplant 14:1917–1921PubMedCrossRef Taal MW, Cassidy MJD, Pearson D, Green D, Masud T (1999) Usefulness of quantitative heel ultrasound compared with dual-energy X-ray absorptiometry in determining bone mineral density in chronic haemodialysis patients. Nephrol Dial Transplant 14:1917–1921PubMedCrossRef
47.
go back to reference Peretz A, Penaloza A, Mesquita M et al (2000) Quantitative ultrasound and dual X-ray absorptiometry measurements of the calcaneus in patients on maintenance hemodialysis. Bone 27:287–292PubMedCrossRef Peretz A, Penaloza A, Mesquita M et al (2000) Quantitative ultrasound and dual X-ray absorptiometry measurements of the calcaneus in patients on maintenance hemodialysis. Bone 27:287–292PubMedCrossRef
48.
go back to reference Arici M, Ertuk H, Altun B (2000) Bone mineral density in haemodialysis patients: a comparative study of dual-energy X-ray absorptiometry and quantitative ultrasound. Nephrol Dial Transplant 15:1847–1851PubMedCrossRef Arici M, Ertuk H, Altun B (2000) Bone mineral density in haemodialysis patients: a comparative study of dual-energy X-ray absorptiometry and quantitative ultrasound. Nephrol Dial Transplant 15:1847–1851PubMedCrossRef
49.
go back to reference Pluskiewicz W, Przedlacki J, Drozdzowska B, Wlodarczyk D, Matuszkiewicz-Rowinska J, Adamczyk P (2004) Quantitative ultrasound at hand phalanges in adults with end-stage renal failure. Ultrasound Med Biol 2004 30:455–459CrossRef Pluskiewicz W, Przedlacki J, Drozdzowska B, Wlodarczyk D, Matuszkiewicz-Rowinska J, Adamczyk P (2004) Quantitative ultrasound at hand phalanges in adults with end-stage renal failure. Ultrasound Med Biol 2004 30:455–459CrossRef
50.
go back to reference Guglielmi G, de Terlizzi F, Aucella F, Scillitani A (2006) Quantitative ultrasound technique at the phalanges in discriminating between uremic and osteoporotic patients. Eur J Radiol 60:108–114PubMedCrossRef Guglielmi G, de Terlizzi F, Aucella F, Scillitani A (2006) Quantitative ultrasound technique at the phalanges in discriminating between uremic and osteoporotic patients. Eur J Radiol 60:108–114PubMedCrossRef
51.
go back to reference Foldes AJ, Arnon E, Propovtzer MM (1996) Reduced speed of sound in tibial bone of hemodialysed patients: association with serum PTH level. Nephrol Dial Transplant 11:1318–1321PubMed Foldes AJ, Arnon E, Propovtzer MM (1996) Reduced speed of sound in tibial bone of hemodialysed patients: association with serum PTH level. Nephrol Dial Transplant 11:1318–1321PubMed
52.
go back to reference Guglielmi G, de Terlizzi F, Aucella F (2004) Quantitative ultrasound: clinical applications. G Ital Nefrol 21:343–354PubMed Guglielmi G, de Terlizzi F, Aucella F (2004) Quantitative ultrasound: clinical applications. G Ital Nefrol 21:343–354PubMed
53.
go back to reference Mauloni M, Rovati LC, Cadossi R, de Terlizzi F, Ventura V, de Aloysio D (2000) Monitoring bone effect of transdermal hormone replacement therapy by ultrasound investigation at the phalanx. A Four Year Follow up Study. Menopause 7:402–412 Mauloni M, Rovati LC, Cadossi R, de Terlizzi F, Ventura V, de Aloysio D (2000) Monitoring bone effect of transdermal hormone replacement therapy by ultrasound investigation at the phalanx. A Four Year Follow up Study. Menopause 7:402–412
54.
go back to reference Glüer CC (1999) Monitoring skeletal changes by radiological techniques. J Bone Miner Res. 14:1952–62PubMedCrossRef Glüer CC (1999) Monitoring skeletal changes by radiological techniques. J Bone Miner Res. 14:1952–62PubMedCrossRef
55.
go back to reference Ingle BM, Machado AB, Pereda CA, Eastell R (2005) Monitoring alendronate and oestradiol therapy with quantitative ultrasound and bone mineral density. J Clin Densitom 8:278–286PubMedCrossRef Ingle BM, Machado AB, Pereda CA, Eastell R (2005) Monitoring alendronate and oestradiol therapy with quantitative ultrasound and bone mineral density. J Clin Densitom 8:278–286PubMedCrossRef
56.
go back to reference Gonnelli S, Cepollaro C, Montagnani A et al (2002) Heel ultrasonography in monitoring alendronate therapy: a four-year longitudinal study. Osteoporos Int 13:415–21PubMedCrossRef Gonnelli S, Cepollaro C, Montagnani A et al (2002) Heel ultrasonography in monitoring alendronate therapy: a four-year longitudinal study. Osteoporos Int 13:415–21PubMedCrossRef
57.
go back to reference Agostinelli D, de Terlizzi F (2007) QUS in monitoring raloxifene and estrogen-progestogens: a 4-year longitudinal study. Ultrasound Med Biol 33:1184–1190PubMedCrossRef Agostinelli D, de Terlizzi F (2007) QUS in monitoring raloxifene and estrogen-progestogens: a 4-year longitudinal study. Ultrasound Med Biol 33:1184–1190PubMedCrossRef
58.
go back to reference Lange U, Illgner U, Teichmann J, Schleenbecker H et al (2004) Skeletal benefit after one year of risedronate therapy in patients with rheumatoid arthritis and glucocorticoid-induced osteoporosis: a prospective study. Int J Clin Pharmacol Res 24:33–38PubMed Lange U, Illgner U, Teichmann J, Schleenbecker H et al (2004) Skeletal benefit after one year of risedronate therapy in patients with rheumatoid arthritis and glucocorticoid-induced osteoporosis: a prospective study. Int J Clin Pharmacol Res 24:33–38PubMed
59.
go back to reference Gonnelli S, Cepollaro C, Pondrelli C (1996) Ultrasound parameters in osteoporotic patients treated with salmon calcitonin: a longitudinal study. Osteoporos Int 6:303–207PubMedCrossRef Gonnelli S, Cepollaro C, Pondrelli C (1996) Ultrasound parameters in osteoporotic patients treated with salmon calcitonin: a longitudinal study. Osteoporos Int 6:303–207PubMedCrossRef
60.
go back to reference Frost ML, Blake GM, Fogelman I (2001) Changes in QUS and BMD measurements with antiresorptive therapy: a two-year longitudinal study. Calcif Tissue Int 69:138–46PubMedCrossRef Frost ML, Blake GM, Fogelman I (2001) Changes in QUS and BMD measurements with antiresorptive therapy: a two-year longitudinal study. Calcif Tissue Int 69:138–46PubMedCrossRef
61.
go back to reference Gonnelli S, Martini G, Caffarelli C et al (2006) Teriparatide’s effects on quantitative ultrasound parameters and bone density in women with established osteoporosis. Osteoporos Int 17:1524–1531PubMedCrossRef Gonnelli S, Martini G, Caffarelli C et al (2006) Teriparatide’s effects on quantitative ultrasound parameters and bone density in women with established osteoporosis. Osteoporos Int 17:1524–1531PubMedCrossRef
62.
go back to reference World Health Organization (WHO) 1994 Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. WHO Technical Report. Series 843, WHO Geneve. World Health Organization (WHO) 1994 Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. WHO Technical Report. Series 843, WHO Geneve.
63.
go back to reference WHO SCIENTIFIC GROUP ON THE ASSESSMENT OF OSTEOPOROSIS AT PRIMARY HEALTH CARE LEVEL. Summary Meeting Report Brussels, Belgium, 5–7 May 2004 WHO SCIENTIFIC GROUP ON THE ASSESSMENT OF OSTEOPOROSIS AT PRIMARY HEALTH CARE LEVEL. Summary Meeting Report Brussels, Belgium, 5–7 May 2004
64.
65.
go back to reference Kanis JA, Johnell O, Oden A et al (2005) Ten-year probabilities of clinical vertebral fractures according to phalangeal quantitative ultrasonography. Osteoporos Int 16:1065–1070PubMedCrossRef Kanis JA, Johnell O, Oden A et al (2005) Ten-year probabilities of clinical vertebral fractures according to phalangeal quantitative ultrasonography. Osteoporos Int 16:1065–1070PubMedCrossRef
66.
go back to reference van den Bergh JP, Noordam C, Ozyilmaz A, Hermus AR, Smals AG, Otten BJ (2000) Calcaneal ultrasound imaging in healthy children and adolescents: relation of the ultrasound parameters BUA and SOS to age, body weight, height, foot dimensions and pubertal stage. Osteoporos Int 11:967–976PubMedCrossRef van den Bergh JP, Noordam C, Ozyilmaz A, Hermus AR, Smals AG, Otten BJ (2000) Calcaneal ultrasound imaging in healthy children and adolescents: relation of the ultrasound parameters BUA and SOS to age, body weight, height, foot dimensions and pubertal stage. Osteoporos Int 11:967–976PubMedCrossRef
67.
go back to reference Sawyer A, Moore S, Fielding KT, Nix DA, Kiratli J, Bachrach LK (2001) Calcaneus ultrasound measurements in a convenience sample of healthy youth. J Clin Densitom 4:111–120PubMedCrossRef Sawyer A, Moore S, Fielding KT, Nix DA, Kiratli J, Bachrach LK (2001) Calcaneus ultrasound measurements in a convenience sample of healthy youth. J Clin Densitom 4:111–120PubMedCrossRef
68.
go back to reference Barkmann R, Rohrschneider W, Vierling M et al (2002) German pediatric reference data for quantitative transverse transmission ultrasound of finger phalanges. Osteoporos Int 13:55–61PubMedCrossRef Barkmann R, Rohrschneider W, Vierling M et al (2002) German pediatric reference data for quantitative transverse transmission ultrasound of finger phalanges. Osteoporos Int 13:55–61PubMedCrossRef
69.
go back to reference Halaba ZP, Pluskiewicz W (2004) Quantitative ultrasound in the assessment of skeletal status in children and adolescents. Ultrasound Med Biol 30:239–243PubMedCrossRef Halaba ZP, Pluskiewicz W (2004) Quantitative ultrasound in the assessment of skeletal status in children and adolescents. Ultrasound Med Biol 30:239–243PubMedCrossRef
70.
go back to reference Zadik Z, Price D, Diamond G (2003) Pediatric reference curves for multi-site quantitative ultrasound and its modulators. Osteoporos Int 14:857–862PubMedCrossRef Zadik Z, Price D, Diamond G (2003) Pediatric reference curves for multi-site quantitative ultrasound and its modulators. Osteoporos Int 14:857–862PubMedCrossRef
71.
go back to reference Lequin MH, van Rijn RR, Robben SG, Hop WC, van Kuijk C (2000) Normal values for tibial quantitative ultrasonometry in caucasian children and adolescents (aged 6 to 19 years). Calcif Tissue Int 67:101–105PubMedCrossRef Lequin MH, van Rijn RR, Robben SG, Hop WC, van Kuijk C (2000) Normal values for tibial quantitative ultrasonometry in caucasian children and adolescents (aged 6 to 19 years). Calcif Tissue Int 67:101–105PubMedCrossRef
72.
go back to reference Zadik Z, Price D, Diamond G (2003) Pediatric reference curves for multi-site quantitative ultrasound and its modulators. Osteoporos Int 14:857–862PubMedCrossRef Zadik Z, Price D, Diamond G (2003) Pediatric reference curves for multi-site quantitative ultrasound and its modulators. Osteoporos Int 14:857–862PubMedCrossRef
73.
go back to reference Lewiecki EM, Watts NB, McClung MR et al (2004) Official positions of the international society for clinical densitometry. J Clin Endocrinol Metab 89:3651–3655PubMedCrossRef Lewiecki EM, Watts NB, McClung MR et al (2004) Official positions of the international society for clinical densitometry. J Clin Endocrinol Metab 89:3651–3655PubMedCrossRef
74.
go back to reference Schalamon J, Singer G, Schwantzer G, Nietosvaara Y (2004) Quantitative ultrasound assessment in children with fractures. J Bone Miner Res 19:1276–1279PubMedCrossRef Schalamon J, Singer G, Schwantzer G, Nietosvaara Y (2004) Quantitative ultrasound assessment in children with fractures. J Bone Miner Res 19:1276–1279PubMedCrossRef
75.
go back to reference Halaba ZP, Konstantynowicz J, Pluskiewicz W, Kaczmarski M, Piotrowska-Jastrzebska J (2005) Comparison of phalangeal ultrasound and dual energy X-ray absorptiometry in healthy male and female adolescents. Ultrasound Med Biol 31:1617–1622PubMedCrossRef Halaba ZP, Konstantynowicz J, Pluskiewicz W, Kaczmarski M, Piotrowska-Jastrzebska J (2005) Comparison of phalangeal ultrasound and dual energy X-ray absorptiometry in healthy male and female adolescents. Ultrasound Med Biol 31:1617–1622PubMedCrossRef
76.
go back to reference Fielding KT, Nix DA, Bachrach LK (2003) Comparison of calcaneus ultrasound and dual X-ray absorptiometry in children at risk of osteopenia. J Clin Densitom 6:7–15PubMedCrossRef Fielding KT, Nix DA, Bachrach LK (2003) Comparison of calcaneus ultrasound and dual X-ray absorptiometry in children at risk of osteopenia. J Clin Densitom 6:7–15PubMedCrossRef
77.
go back to reference Hartman C, Brik R, Tamir A, Merrick J, Shamir R (2004) Bone quantitative ultrasound and nutritional status in severely handicapped institutionalized children and adolescents. Clin Nutr 23:89–98PubMedCrossRef Hartman C, Brik R, Tamir A, Merrick J, Shamir R (2004) Bone quantitative ultrasound and nutritional status in severely handicapped institutionalized children and adolescents. Clin Nutr 23:89–98PubMedCrossRef
78.
go back to reference Meadow W, Lee G, Lin K, Lantos J (2004) Changes in mortality for extremely low birth weight infants in the 1990s: implications for treatment decisions and resource use. Pediatrics 113:1223–1229PubMedCrossRef Meadow W, Lee G, Lin K, Lantos J (2004) Changes in mortality for extremely low birth weight infants in the 1990s: implications for treatment decisions and resource use. Pediatrics 113:1223–1229PubMedCrossRef
79.
go back to reference Rubinacci A, Moro GE, Noehm G et al (2003) Quantitative ultrasound for the assessment of osteopenia in preterm infants. Eur J Endocrinol 149:307–315PubMedCrossRef Rubinacci A, Moro GE, Noehm G et al (2003) Quantitative ultrasound for the assessment of osteopenia in preterm infants. Eur J Endocrinol 149:307–315PubMedCrossRef
80.
go back to reference Ritschl E, Wehmeijer K, De Terlizzi F et al (2005) Assessment of skeletal development in preterm and term infants by quantitative ultrasound. Pediatr Res 58:341–346PubMedCrossRef Ritschl E, Wehmeijer K, De Terlizzi F et al (2005) Assessment of skeletal development in preterm and term infants by quantitative ultrasound. Pediatr Res 58:341–346PubMedCrossRef
81.
go back to reference Tomlinson C, McDevitt H, White MP, Ahmed SF (2006) Longitudinal changes in bone health as assessed by the speed of sound in very low birth weight preterm infants. J Pediatr 148:450–455PubMedCrossRef Tomlinson C, McDevitt H, White MP, Ahmed SF (2006) Longitudinal changes in bone health as assessed by the speed of sound in very low birth weight preterm infants. J Pediatr 148:450–455PubMedCrossRef
82.
go back to reference Littner Y, Mandel D, Mimouni FB, Dollberg S (2003) Bone ultrasound velocity curves of newly born term and preterm infants. J Pediatr Endocrinol 16:43–7 Littner Y, Mandel D, Mimouni FB, Dollberg S (2003) Bone ultrasound velocity curves of newly born term and preterm infants. J Pediatr Endocrinol 16:43–7
83.
go back to reference Nemet D, Dolfin T, Wolach B, Eliakim A (2001) Quantitative ultrasound measurements of bone speed of sound in premature infants. Eur J Pediatr 160:736–740PubMed Nemet D, Dolfin T, Wolach B, Eliakim A (2001) Quantitative ultrasound measurements of bone speed of sound in premature infants. Eur J Pediatr 160:736–740PubMed
84.
go back to reference Eliakim A, Nemet D, Friedland O, Dolfin T, Regev R (2002) Spontaneous activity in premature infants affects bone strength. J Perinatol 22:650–652PubMedCrossRef Eliakim A, Nemet D, Friedland O, Dolfin T, Regev R (2002) Spontaneous activity in premature infants affects bone strength. J Perinatol 22:650–652PubMedCrossRef
85.
go back to reference Litmanovitz I, Dolfin T, Friedland O (2003) A: Early physical activity prevents decrease of bone strength in very low birth weight infants. Pediatrics 112:15–19PubMedCrossRef Litmanovitz I, Dolfin T, Friedland O (2003) A: Early physical activity prevents decrease of bone strength in very low birth weight infants. Pediatrics 112:15–19PubMedCrossRef
86.
go back to reference Pocock NA, Eisman JA, Hopper JL, Yeates MG, Sambrook PN, Eberl S (1987) Genetic determinants of bone mass in adults: a twin study. J Clin Invest 80:706–710PubMedCrossRef Pocock NA, Eisman JA, Hopper JL, Yeates MG, Sambrook PN, Eberl S (1987) Genetic determinants of bone mass in adults: a twin study. J Clin Invest 80:706–710PubMedCrossRef
87.
go back to reference Dequeker J, Nijs J, Verstraeten A, Geusens P, Gevers G (1987) Genetic determinants of bone mineral content at the spine and radius: a twin study. Bone 8:207–209PubMedCrossRef Dequeker J, Nijs J, Verstraeten A, Geusens P, Gevers G (1987) Genetic determinants of bone mineral content at the spine and radius: a twin study. Bone 8:207–209PubMedCrossRef
88.
go back to reference Arden NK, Baker J, Hogg C, Baan K, Spector TD (1996) The heritability of bone mineral density, ultrasound of the calcaneus and hip axis length: a study of postmenopausal twins. J Bone Miner Res 11:530–534PubMedCrossRef Arden NK, Baker J, Hogg C, Baan K, Spector TD (1996) The heritability of bone mineral density, ultrasound of the calcaneus and hip axis length: a study of postmenopausal twins. J Bone Miner Res 11:530–534PubMedCrossRef
89.
go back to reference Howard G, Nguien TV, Harris M, Kelly PJ, Eisman JA (1998) Genetic and environmental contributions to the association between quantitative ultrasound and bone mineral density measurements: a twin study. J Bone Miner Res 13:1318–1327PubMedCrossRef Howard G, Nguien TV, Harris M, Kelly PJ, Eisman JA (1998) Genetic and environmental contributions to the association between quantitative ultrasound and bone mineral density measurements: a twin study. J Bone Miner Res 13:1318–1327PubMedCrossRef
90.
go back to reference Guglielmi G, de Terlizzi F, Torrente I, Mingarelli R, Dallapiccola B (2005) Quantitative ultrasound of the hand phalanges in a cohort of monozygotic twins: influence of genetic and environmental factors. Skeletal Radiol 34:727–735PubMedCrossRef Guglielmi G, de Terlizzi F, Torrente I, Mingarelli R, Dallapiccola B (2005) Quantitative ultrasound of the hand phalanges in a cohort of monozygotic twins: influence of genetic and environmental factors. Skeletal Radiol 34:727–735PubMedCrossRef
91.
go back to reference Gluer C-C (2008) A new quality of bone ultrasound research. IEEE Trans Ultrason Ferroelectr Freq Control 55(7):1524–1528PubMedCrossRef Gluer C-C (2008) A new quality of bone ultrasound research. IEEE Trans Ultrason Ferroelectr Freq Control 55(7):1524–1528PubMedCrossRef
92.
go back to reference Laugier P (2008) Instrumentation for in vivo ultrasonic characterization of bone strength. IEEE Trans Ultrason Ferroelectr Freq Control 55(6):1179–1196PubMedCrossRef Laugier P (2008) Instrumentation for in vivo ultrasonic characterization of bone strength. IEEE Trans Ultrason Ferroelectr Freq Control 55(6):1179–1196PubMedCrossRef
Metadata
Title
Quantitative ultrasound in the assessment of skeletal status
Authors
Giuseppe Guglielmi
Judith Adams
Thomas M. Link
Publication date
01-08-2009
Publisher
Springer-Verlag
Published in
European Radiology / Issue 8/2009
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-009-1354-1

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