Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
European Radiology
Published in: European Radiology 6/2009

01-06-2009 | Musculoskeletal

Glucosamine sulfate effect on the degenerated patellar cartilage: preliminary findings by pharmacokinetic magnetic resonance modeling

Authors: Luis Martí-Bonmatí, Roberto Sanz-Requena, José Luis Rodrigo, Ángel Alberich-Bayarri, José Miguel Carot

Published in: European Radiology | Issue 6/2009

Login to get access

Abstract

Normal and degenerated cartilages have different magnetic resonance (MR) capillary permeability (Ktrans) and interstitial interchangeable volume (ve). Our hypothesis was that glucosamine sulfate treatment modifies these neovascularity abnormalities in osteoarthritis. Sixteen patients with patella degeneration, randomly distributed into glucosamine or control groups, underwent two 1.5-Tesla dynamic contrast-enhanced MR imaging studies (treatment initiation and after 6 months). The pain visual analog scale (VAS) and American Knee Society (AKS) score were used. A two-compartment pharmacokinetic model was used. Percentages of variations (postreatment-pretreatment/pretreatment) were compared (t-test for independent data). In the glucosamine group, pain and functional outcomes statistically improved (VAS: 7.3 ± 1.1 to 3.6 ± 1.3, p < 0.001; AKS: 18.6 ± 6.9 to 42.9 ± 2.7, p < 0.01). Glucosamine significantly increased Ktrans at 6 months (−54.4 ± 21.2% vs 126.7 ± 56.9%, p < 0.001, control vs glucosamine). In conclusion, glucosamine sulfate decreases pain while improving functional outcome in patients with cartilage degeneration. Glucosamine sulfate increases Ktrans, allowing its proposal as a surrogate imaging biomarker after 6 months of treatment.
Literature
1.
Krasnokutsky S, Samuels J, Abramson SB (2007) Osteoarthritis in 2007. Bulletin NYU Hosp Jt Dis 65:222–228
2.
Sanz R, Marti-Bonmati L, Rodrigo JL, Moratal D (2008) MR pharmacokinetic modeling of the patellar cartilage differentiates normal from pathological conditions. J Magn Reson Imaging 27:171–177PubMedCrossRef
3.
Gold GE, McCauley TR, Gray ML, Disler DG (2003) What’s new in cartilage? Radiographics 23:1227–1242PubMedCrossRef
4.
Brittberg M, Winalski CS (2003) Evaluation of cartilage injuries and repair. J Bone Joint Surg Am 85:58–69PubMed
5.
Bobinac D, Spanjol J, Zoricic S, Maric I (2003) Changes in articular cartilage and subchondral bone histomorphometry in osteoarthritic knee joints in humans. Bone 32:284–290PubMedCrossRef
6.
Enomoto H, Inoki I, Komiya K, Shiomi T, Ikeda E, Obata K, Matsumoto H, Toyama Y, Okada Y (2003) Vascular endothelial growth factor isoforms and their receptors are expressed in human osteoarthritic cartilage. Am J Pathol 162:171–181PubMed
7.
Murata M, Yudoh K, Masuko K (2008) The potential role of vascular endothelial growth factor (VEGF) in cartilage. How the angiogenic factor could be involved in the pathogenesis of osteoarthritis? Osteoarthritis Cartilage 16:279–286PubMedCrossRef
8.
Walsh DA, Bonnet CS, Turner EL, Wilson D, Situ M, McWilliams DF (2007) Angiogenesis in the synovium and at the osteochondral junction in osteoarthritis. Osteoarthritis Cartilage 15:743–751PubMedCrossRef
9.
Smith JO, Oreffo ROC, Clarke NMP, Roach HI (2003) Changes in the antiangiogenic properties of articular cartilage in osteoarthritis. J Orthop Sci 8:849–857PubMedCrossRef
10.
Jackson A, Jayson GC, Li KL, Zhu XP, Checkley DR, Tessier JJ, Waterton JC (2003) Reproducibility of quantitative dynamic contrast-enhanced MRI in newly presenting glioma. Br J Radiol 76:153–162PubMedCrossRef
11.
Padhani AR (2002) Dynamic contrast-enhanced MRI in clinical oncology: current status and future directions. J Magn Reson Imaging 16:407–422PubMedCrossRef
12.
Tofts PS, Brix G, Buckley DL, Evelhoch JL, Henderson E, Knopp MV, Larsson HB, Lee TY, Mayr NA, Parker GJ, Port RE, Taylor J, Weisskoff RM (1999) Estimating kinetic parameters from dynamic contrast-enhanced T1-weighted MRI of a diffusable tracer: standardized quantities and symbols. J Magn Reson Imaging 10:223–232PubMedCrossRef
13.
Tofts PS (1997) Modeling tracer kinetics in dynamic Gd-DTPA MR imaging. J Magn Reson Imaging 7:91–101PubMedCrossRef
14.
Rovati LC, Pavelka K, Giacovelli G, Reginster JY (2006) Assessment of joint space narrowing with conventional standing antero-posterior radiographs: relief in mild-to-moderate pain is not a confounder in recent osteoarthritis structure-modifying drug trials. Osteoarthritis Cartilage 14(Suppl A):A14–A18PubMedCrossRef
15.
Bruyer O, Pavelka K, Rovati LC, Deroisy R, Olejarova M, Gatterova J, Giacovelli G, Reginster JY (2004) Glucosamine sulfate reduces osteoarthritis progression in postmenopausal women with knee osteoarthritis: evidence from two 3-year studies. Menopause 11:138–143CrossRef
16.
Liow RY, Walker K, Wajid MA, Bedi G, Lennox CME (2000) The reliability of the American Knee Society Score. Acta Orthop Scand 71:603–608PubMedCrossRef
17.
Marquardt D (1963) An algorithm for least squares estimation of nonlinear parameters. J Soc Indust Appl Math 11:431–441CrossRef
18.
Imhof H, Sulzbacher I, Grampp S, Czerny C, Youssefzadeh S, Kainberger F (2000) Subchondral bone and cartilage disease: a rediscovered functional unit. Invest Radiol 35:581–588PubMedCrossRef
19.
Slater RNS, Spencer JD, Churchill MA, Bridgeman GP, Brookes M (1991) Observations on the intrinsic blood supply to the human patella: disruption correlated with articular surface degeneration. J R Soc Med 84:606–607PubMed
20.
Scharf J, Kemmling A, Hess T, Mehrabi A, Kauffmann G, Groden C, Brix G (2007) Assessment of hepatic perfusion in transplanted livers by pharmacokinetic analysis of dynamic magnetic resonance measurements. Invest Radiol 42:224–229PubMedCrossRef
21.
Martí-Bonmatí L, Sanz-Requena R, Alberich-Bayarri A (2008) Pharmacokinetic MR analysis of the cartilage is influenced by field strength. Eur J Radiol 67:448–452PubMedCrossRef
22.
Buckley DL (2002) Uncertainty in the analysis of tracer kinetics using dynamic contrast-enhanced T1-weighted MRI. Magn Reson Med 47:601–606PubMedCrossRef
23.
Padhani AR, Hayes C, Landau S, Leach MO (2002) Reproducibility of quantitative dynamic MRI of normal human tissues. NMR Biomed 15:143–153PubMedCrossRef
Metadata
Title
Glucosamine sulfate effect on the degenerated patellar cartilage: preliminary findings by pharmacokinetic magnetic resonance modeling
Authors
Luis Martí-Bonmatí
Roberto Sanz-Requena
José Luis Rodrigo
Ángel Alberich-Bayarri
José Miguel Carot
Publication date
01-06-2009
Publisher
Springer-Verlag
Published in
European Radiology / Issue 6/2009
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-008-1286-1

Other articles of this Issue 6/2009

European Radiology 6/2009 Go to the issue

Nuclear Medicine

Accuracy of integrated FDG-PET/contrast-enhanced CT in detecting pelvic and paraaortic lymph node metastasis in patients with uterine cancer

Magnetic Resonance

Diagnostic performance of diffusion-weighted magnetic resonance imaging in esophageal cancer

Letter to the Editor

Characterisation of peripartum cardiomyopathy by cardiac magnetic resonance imaging

Chest

Bronchial morphometry in smokers: comparison with healthy subjects by using 3D CT

Neuro

Tumour enhancing fraction (EnF) in glioma: relationship to tumour grade

Pediatric

Microstructural callosal abnormalities in normal-appearing brain of children with developmental delay detected with diffusion tensor imaging