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European Radiology
Published in: European Radiology 8/2008

01-08-2008 | Neuro

Proton MR spectroscopy of cerebral gliomas at 3 T: spatial heterogeneity, and tumour grade and extent

Authors: Alfonso Di Costanzo, Tommaso Scarabino, Francesca Trojsi, Teresa Popolizio, Domenico Catapano, Giuseppe M. Giannatempo, Simona Bonavita, Maurizio Portaluri, Michela Tosetti, Vincenzo A. d’Angelo, Ugo Salvolini, Gioacchino Tedeschi

Published in: European Radiology | Issue 8/2008

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Abstract

This study aimed to evaluate the usefulness of proton MR spectroscopic imaging (1H-MRSI) at 3 T in differentiating high- from low-grade gliomas, and tumour from necrosis, oedema or normal tissue. Forty-four patients with brain gliomas and four with meningiomas were retrospectively reviewed. The normalised metabolites choline (nCho), N-acetylaspartate (nNAA), creatine (nCr) and lactate/lipids (nLL), and the metabolite ratios Cho/NAA, NAA/Cr and Cho/Cr were calculated. Necrotic-appearing areas showed two spectroscopic patterns: “necrosis” with variable nCho and high nLL, and “cystic necrosis” with variable nLL or nonevident peaks. Peri-enhancing oedematous-appearing areas showed three spectroscopic patterns (“tumour” with abnormal Cho/NAA, “oedema” with normal Cho/NAA and “tumour/oedema” with normal nCho and abnormal Cho/NAA) in gliomas, and one (“oedema”) in meningiomas. Peri-enhancing or peri-tumour normal-appearing areas showed two patterns (“infiltrated” with abnormal nCho and/or Cho/NAA and “normal” with normal spectra) in gliomas and one (“normal”) in meningiomas. Discriminant analysis showed that classification accuracy between high- and low-grade glioma masses was better with normalised metabolites or all parameters together than metabolite ratios and that among peri-enhancing areas was much better with normalised metabolites. The analysis of spatial distribution of normalised metabolites by 3-T 1H-MRSI helps to discriminate among different tissues, offering information not available with conventional MRI.
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Metadata
Title
Proton MR spectroscopy of cerebral gliomas at 3 T: spatial heterogeneity, and tumour grade and extent
Authors
Alfonso Di Costanzo
Tommaso Scarabino
Francesca Trojsi
Teresa Popolizio
Domenico Catapano
Giuseppe M. Giannatempo
Simona Bonavita
Maurizio Portaluri
Michela Tosetti
Vincenzo A. d’Angelo
Ugo Salvolini
Gioacchino Tedeschi
Publication date
01-08-2008
Publisher
Springer-Verlag
Published in
European Radiology / Issue 8/2008
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-008-0938-5

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