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European Radiology
Published in: European Radiology 12/2007

01-12-2007 | Interpretation Corner

Lacrimal gland and perioptic nerve lesions due to Langerhans cell histiocytosis (2007: 9b)

Authors: M. Herman, P. Demaerel, G. Wilms, S. Van Gool, I. Casteels

Published in: European Radiology | Issue 12/2007

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Abstract

We report a patient presenting with bilateral lacrimal gland involvement and perioptic nerve sheath lesions due to Langerhans cell histiocytosis (LCH) invasion. LCH is a rare multisystemic disease characterized by a clonal proliferation of Langerhans cells. All organs may be involved with a clinical spectrum ranging from a solitary bone lesion to a severe life-threatening multisystem disease. Osteolytic orbital bone lesions with extension into the adjacent orbital soft tissues have been described. To our knowledge, lacrimal gland involvement has probably been described only once before. Perioptic nerve lesions are also very rare, having been described only three times before.
Literature
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Meyer JS, Harty MP, Mahboubi S (1995) Langerhans cell histiocytosis: presentation and evolution of radiologic findings with clinical correlation. Radiographics 15(11):1135–1146PubMed
2.
Kilborn TN, Teh J, Goodman TR (2003) Paediatric manifestations of Langerhans cell histiocytosis: a review of the clinical and radiological findings. Clin Radiol 58(4):269–278PubMedCrossRef
3.
Feltgen N, Auw-Hadrich C, Gerling J (2002) Idiopathic eosinophilic pseudotumor of the lacrimal gland in a child. Klin Monatsbl Augenheilkd 219(6):458–461PubMedCrossRef
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Ho Yuen V, Jordan DR, Brownstein S et al (2003) Bilateral perioptic nerve lesions in a patient with Langerhans-cell histiocytosis. Can J Ophthalmol 38(6):496–500PubMed
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MacCumber MS, Hoffman PN, Wand GS et al (1990) Ophthalmic involvement in aggressive histiocystosis X. Ophthalmology 97(1):22–27PubMed
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Grois N, Barkovich AJ, Rosenau W et al (1993) Central nervous system disease associated with Langerhans’ cell histiocytosis. Am J Pediatr Hematol Oncol 15(2):245–254PubMedCrossRef
Metadata
Title
Lacrimal gland and perioptic nerve lesions due to Langerhans cell histiocytosis (2007: 9b)
Authors
M. Herman
P. Demaerel
G. Wilms
S. Van Gool
I. Casteels
Publication date
01-12-2007
Publisher
Springer-Verlag
Published in
European Radiology / Issue 12/2007
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-007-0611-4

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