Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
European Radiology

01-09-2007 | Experimental

Multidetector CT urography: experimental analysis of radiation dose reduction in an animal model

Published in: European Radiology | Issue 9/2007

Login to get access

Abstract

The purpose of this study was to evaluate the possibility of reducing X-ray exposure during multidetector CT urography (MDCTU) considering image quality using a porcine model. MDCTU was performed in eight healthy pigs. Scanning was conducted using a gradual reduction of the tube current-time product at 120 kV [200–20 mAs (eff.) in ten steps]. Three blinded observers independently evaluated the image data for anatomic detail, subjective image quality, and subjective image noise. Overall image quality was compared to milliampere-second settings and radiation dose. Objective noise measurements were assessed. Noise measurements in patients were also performed to verify the comparabilty of the animal model. Adequate image quality allowing for detailed visualization of the upper urinary tract was obtained when the tube current-time product was decreased to 70 eff. mAs at 120 kV. Image noise did not impair image quality to a relevant degree using these parameters. There was high agreement among the observers (ICC = 0.95). In the animal experiments, reduced-dose MDCTU produced good image quality. A maximum current-time product reduction to 70 eff. mAs at 120 kV (CTDIvol = 5.3 mGy) proved to be feasible, thereby offering an advantageous dosage reduction. The study provides a basis for the development of reduced-dose MDCTU protocols in humans.
Literature
1.
Mettler FA Jr, Wiest PW, Locken JA, Kelsey CA (2000) CT scanning: patterns of use and dose. J Radiol Prot 20:353–359PubMedCrossRef
2.
Nolte-Ernsting C, Cowan N (2006) Understanding multislice CT urography techniques: many roads lead to Rome. Eur Radiol 16(12):2670–2686PubMedCrossRef
3.
Caoili EM, Inampudi P, Cohan RH, Ellis JH (2005) Optimization of multi-detector row CT urography: effect of compression, saline administration, and prolongation of acquisition delay. Radiology 235:116–123PubMedCrossRef
4.
Kemper J, Regier M, Begemann PG, Stork A, Adam G, Nolte-Ernsting C (2005) Multislice computed tomography-urography: intraindividual comparison of different preparation techniques for optimized depiction of the upper urinary tract in an animal model. Invest Radiol 40:126–133PubMedCrossRef
5.
Kemper J, Regier M, Stork A, Adam G, Nolte-Ernsting C (2006) Multislice CT urography (MSCTU): Evaluation of a modified scan protocol for optimized opacification of the collecting system. FortschrRöntgenstr 178:531–537
6.
McTavish JD, Jinzaki M, Zou KH, Nawfel RD, Silverman SG (2002) Multi-detector row CT urography: comparison of strategies for depicting the normal urinary collecting system. Radiology 225:783–790PubMedCrossRef
7.
Kemper J, Adam G, Nolte-Ernsting C (2005) Multislice CT urography: Aspects for technical management and clinical application. Radiologe 45:905–914PubMedCrossRef
8.
Nolte-Ernsting CC, Wildberger JE, Borchers H, Schmitz-Rode T, Gunther RW (2001) Multi-slice CT urography after diuretic injection: initial results. Fortschr Rontgenstr 173:176–180CrossRef
9.
Kemper J, Adam G, Nolte-Ernsting C (2006) Modern diagnostic assessment of the upper urinary tract using multislice CT urography. FortschrRöntgenstr 178:1086–1094
10.
Wedegartner U, Lorenzen M, Lorenzen J, Nolte-Ernsting C, Weber C, Dieckmann C, Cramer M, Schoder V, Adam G (2004) Multislice CT of the pelvis: dose reduction with regard to image quality. FortschrRöntgenstr 176:106–112
11.
Gurung J, Khan MF, Maataoui A, Herzog C, Bux R, Bratzke H, Ackermann H, Vogl TJ (2005) Multislice CT of the pelvis: dose reduction with regard to image quality using 16-row CT. Eur Radiol 15:1898–1905PubMedCrossRef
12.
Wildberger JE, Max M, Wein BB, Mahnken AH, Weiss C, Dembinski R, Katoh M, Schaller S, Rossaint R, Gunther RW (2003) Low-dose multislice spiral computed tomography in acute lung injury: animal experience. Invest Radiol 38:9–16PubMedCrossRef
13.
Honnef D, Wildberger JE, Stargardt A, Hohl C, Barker M, Gunther RW, Staatz G (2004) Multislice spiral CT (MSCT) in pediatric radiology: dose reduction for chest and abdomen examinations. FortschrRöntgenstr 176:1021–1030
14.
Stamm G, Nagel HD (2002) CT-expo-a novel program for dose evaluation in CT. FortschrRöntgenstr 174:157–1576
15.
Coppenrath E, Meindl T, Herzog P, Khalil R, Mueller-Lisse U, Krenn L, Reiser M, Mueller-Lisse UG (2006) Dose reduction in multidetector CT of the urinary tract. Studies in a phantom model. Eur Radiol 16:1982–1989PubMedCrossRef
16.
Wintersperger B, Jakobs T, Herzog P, Schaller S, Nikolaou K, Suess C, Weber C, Reiser M, Becker C (2005) Aorto-iliac multidetector-row CT angiography with low kV settings: improved vessel enhancement and simultaneous reduction of radiation dose. Eur Radiol 15:334–341PubMedCrossRef
17.
Theocharopoulos N, Perisinakis K, Damilakis J, Karampekios S, Gourtsoyiannis N (2006) Dosimetric characteristics of a 16-slice computed tomography scanner. Eur Radiol 16:2575–2585PubMedCrossRef
18.
Hohl C, Muhlenbruch G, Wildberger JE, Leidecker C, Suss C, Schmidt T, Gunther RW, Mahnken AH (2006) Estimation of radiation exposure in low-dose multislice computed tomography of the heart and comparison with a calculation program. Eur Radiol 16:1841–1846PubMedCrossRef
19.
Fraioli F, Catalano C, Napoli A, Francone M, Venditti F, Danti M, Pediconi F, Passariello R (2006) Low-dose multidetector-row CT angiography of the infra-renal aorta and lower extremity vessels: image quality and diagnostic accuracy in comparison with standard DSA. Eur Radiol 16:137–146PubMedCrossRef
20.
Nawfel RD, Judy PF, Schleipman AR, Silverman SG (2004) Patient radiation dose at CT urography and conventional urography. Radiology 232:126–132PubMedCrossRef
21.
Caoili EM, Cohan RH, Korobkin M, Platt JF, Francis IR, Faerber GJ, Montie JE, Ellis JH (2002) Urinary tract abnormalities: initial experience with multi-detector row CT urography. Radiology 222:353–360PubMedCrossRef
22.
Isoardi P, Ropolo R, Savio L, Cesarani F, Marchisio F, Gandini G (2004) Patient dose evaluation and optimization of uropoietic multiphasic multislice CT examination. Radiol Med (Torino) 107:218–228
23.
Kalra MK, Prasad S, Saini S, Blake MA, Varghese J, Halpern EF, Thrall JH, Rhea JT (2002) Clinical comparison of standard-dose and 50% reduced-dose abdominal CT: effect on image quality. AJR Am J Roentgenol 179:1101–1106PubMed
24.
Prasad SR, Wittram C, Shepard JA, McLoud T, Rhea J (2002) Standard-dose and 50%-reduced-dose chest CT: comparing the effect on image quality. AJR Am J Roentgenol 179:461–465PubMed
25.
Galanski M, Nagel HD, Stamm G (2001) CT radiation exposure risk in Germany. FortschrRöntgenstr 173:R1–R66
Metadata
Title
Multidetector CT urography: experimental analysis of radiation dose reduction in an animal model
Publication date
01-09-2007
Published in
European Radiology / Issue 9/2007
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-006-0565-y