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01-07-2007 | Breast

Early mammographic and sonographic findings after intraoperative radiotherapy (IORT) as a boost in patients with breast cancer

Authors: K. Wasser, C. Schoeber, U. Kraus-Tiefenbacher, L. Bauer, J. Brade, J. Teubner, F. Wenz, W. Neff

Published in: European Radiology | Issue 7/2007

Abstract

The aim of this study was to evaluate mammographic and sonographic changes at the surgical site within the first 2 years after IORT as a boost followed by whole-breast radiotherapy (WBRT), compared with a control group treated with WBRT alone. All patients had breast-conserving surgery for early-stage breast cancer. Group A: n = 27, IORT (20 Gy) followed by WBRT (46 Gy). Group B (control group): n = 27, WBRT alone (56–66 Gy). Mammography: fat necrosis in 14 group A versus four group B patients (P < 0.001); parenchymal scarring classified as unorganized at the last follow-up in 16 vs seven cases, respectively (P = 0.03). Ultrasound: overall number of patients with circumscribed findings 27 vs 18 (P < 0.001); particular hematomas/seromas in 26 vs 13 patients (P < 0.001). Synopsis of mammography and ultrasound: overall postoperative changes were significantly higher classified in group A (P = 0.01), but not judged to have a significantly higher impact on interpretation. Additional diagnostic procedures, due to unclear findings at the surgical site, were performed on four patients of both groups. Within the first 2 years after IORT as a boost, therapy-induced changes at the original tumor site are significantly more pronounced compared with a control group. There is no evidence that the interpretation of findings is complicated after IORT.

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Title: Early mammographic and sonographic findings after intraoperative radiotherapy (IORT) as a boost in patients with breast cancer
Authors: K. Wasser
C. Schoeber
U. Kraus-Tiefenbacher
L. Bauer
J. Brade
J. Teubner
F. Wenz
W. Neff
Publication date: 01-07-2007
Publisher: Springer-Verlag
Published in: European Radiology / Issue 7/2007
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-006-0556-z

At a glance: The STEP trials

Springer Medicine

Early mammographic and sonographic findings after intraoperative radiotherapy (IORT) as a boost in patients with breast cancer

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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