Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
European Radiology
Published in: European Radiology 3/2007

01-03-2007 | Vascular-Interventional

Age related changes of human aortic distensibility: evaluation with ECG-gated CT

Authors: Marika Ganten, Ute Krautter, Waldemar Hosch, Jochen Hansmann, Hendrik von Tengg-Kobligk, Stefan Delorme, Hans-Ulrich Kauczor, Günter W. Kauffmann, Michael Bock

Published in: European Radiology | Issue 3/2007

Login to get access

Abstract

Aortic distensibility is a parameter to grade vascular diseases and age-related effects because it is related to the elastic properties of the vessel wall. In this study vascular cross-sectional area changes have been determined using ECG-gated CT to analyse the age dependency of aortic distensibility. Distensibility measurements of the aorta were performed in 31 subjects (28 to 85 years). Time-resolved images were acquired either with a 4- or 16-detector row CT system using a modified CT angiography protocol. Cross-sectional area changes of the aorta were calculated by semiautomatic segmentation, and distensibility values were obtained using additional systemic blood pressure measurements. The aorta could be segmented successfully in all subjects. A decrease of aortic distensibility with age was found (r=0.50). Below (above) the renal arteries, the annual decrease was Δ D infrarenal =(−2.1±0.7)·10−7 Pa−1a−1, (D suprarenal Δ=(−3.5±1.1)·10−7 Pa−1a−1). Differences between the ages, the youngest third and oldest third studied, were found to be significant (P suprarenal =0.003; P infrarenal =0.025). An age-dependent decrease of aortic wall elasticity can be determined in a modified routine CT angiography study.
Literature
1.
Metafratzi ZM, Efremidis SC, Skopelitou AS et al (2002) The clinical significance of aortic compliance and its assessment with magnetic resonance imaging. J Cardiovasc Magn Reson 4(4):481–491CrossRefPubMed
2.
Laurent S, Katsahian S, Fassot C et al (2003) Aortic stiffness is an independent predictor of fatal stroke in essential hypertension. Stroke 34(5):1203–1206CrossRefPubMed
3.
Herrington DM, Kesler K, Reiber JC et al (2003) Arterial compliance adds to conventional risk factors for prediction of angiographic coronary artery disease. Am Heart J 146(4):662–667CrossRefPubMed
4.
Blacher J, Safar ME, Guerin AP et al (2003) Aortic pulse wave velocity index and mortality in end-stage renal disease. Kidney Int 63(5):1852–1860CrossRefPubMed
5.
Boese JM, Bock M, Schoenberg SO et al (2000) Estimation of aortic compliance using magnetic resonance pulse wave velocity measurement. Phys Med Biol 45(6):1703–1713CrossRefPubMed
6.
Kraft KA, Itskovich VV, Fei DY (2001) Rapid measurement of aortic wave velocity: in vivo evaluation. Magn Reson Med 46(1):95–102CrossRefPubMed
7.
Itskovich VV, Kraft KA, Fei DY (2001) Rapid aortic wave velocity measurement with MR imaging. Radiology 219(2):551–557PubMed
8.
Bock M, Schad LR, Muller E et al (1995) Pulse wave velocity measurement using a new real-time MR-method. Magn Reson Imaging 13(1):21–29CrossRefPubMed
9.
Nollen GJ, Westerhof BE, Groenink M et al (2004) Aortic pressure-area relation in Marfan patients with and without beta blocking agents: a new non-invasive approach. Heart 90(3):314–318CrossRefPubMed
10.
Mohiaddin RH, Yang GZ, Burger P et al (1992) Automatic enhancement, animation, and segmentation of flow in peripheral arteries from MR phase-shift velocity mapping. J Comput Assist Tomogr 16(2):176–181PubMedCrossRef
11.
Lalande A, Khau van Kien P, Salve N et al (2002) Automatic determination of aortic compliance with cine-magnetic resonance imaging: an application of fuzzy logic theory. Invest Radiol 37(12):685–691CrossRefPubMed
12.
Wilson KA, Hoskins PR, Lee AJ et al (2000) Ultrasonic measurement of abdominal aortic aneurysm wall compliance: a reproducibility study. J Vasc Surg 31(3):507–513CrossRefPubMed
13.
Long A, Rouet L, Bissery A et al (2004) Aortic compliance in healthy subjects: evaluation of tissue Doppler imaging. Ultrasound Med Biol 30(6):753–759CrossRefPubMed
14.
Erbel R, Alfonso F, Boileau C et al (2001) Diagnosis and management of aortic dissection. Eur Heart J 22(18):1642–1681CrossRefPubMed
15.
Kachelriess M, Ulzheimer S, Kalender WA (2000) ECG-correlated image reconstruction from subsecond multi-slice spiral CT scans of the heart. Med Phys 27(8):1881–1902CrossRefPubMed
16.
Boese JM, Bahner ML, Albers J et al (2000) [Optimizing temporal resolution in CT with retrospective ECG gating]. Radiologe 40(2):123–129CrossRefPubMed
17.
Bahner ML, Boese JM, Wallschläger H et al (1999) Spiral CT of the heart with retrospective ECG-gating. Electromedica 67:37–41
18.
Luboldt W, Straub J, Seemann M et al (1999) Effective contrast use in CT angiography and dual-phase hepatic CT performed with a subsecond scanner. Invest Radiol 34(12):751–760CrossRefPubMed
19.
Bahner ML, Bengel A, Brix G et al (2005) Improved vascular opacification in cerebral computed tomography angiography with 80 kVp. Invest Radiol 40(4):229–234CrossRefPubMed
20.
Ganten M, Boese JM, Leitermann D et al (2005) Quantification of aortic elasticity: development and experimental validation of a method using computed tomography. Eur Radiol
21.
Boese JM, Bahner ML, Albers J, ea (2001) An improved algorithm for multi-slice cardiac CT imaging with high temporal resolution (abstr). Radiology 221(P):457
22.
Lobregt S, Viergever MA (1995) A discrete dynamic contour model. Trans Med Imaging 14:12–24CrossRef
23.
Cohen L (1991) On active contour modelsand ballons. Image Underst 53:211–218CrossRef
24.
Krug R, Boese JM, Schad LR (2003) Determination of aortic compliance from magnetic resonance images using an automatic active contour model. Phys Med Biol 48(15):2391–2404CrossRefPubMed
25.
Malina M, Lanne T, Ivancev K et al (1998) Reduced pulsatile wall motion of abdominal aortic aneurysms after endovascular repair. J Vasc Surg 27(4):624–631CrossRefPubMed
26.
Nichols WW (1990) Properties of the arterial wall. In: Nichols WW, O’ Rourke MF (eds) McDonald’s blood flow in arteries. Edward Arnold, London, p 96
27.
Mohiaddin RH, Schoser K, Amanuma M et al (1990) MR imaging of age-related dimensional changes of thoracic aorta. J Comput Assist Tomogr 14(5):748–752PubMedCrossRef
28.
Schoenberg SO, Wunsch C, Knopp MV et al (1999) Abdominal aortic aneurysm. Detection of multilevel vascular pathology by time-resolved multiphase 3D gadolinium MR angiography: initial report. Invest Radiol 34(10):648–659CrossRefPubMed
29.
Hamilton M, Pickering GW, Roberts JA et al (1954) The aetiology of essential hypertension. I. The arterial pressure in the general population. Clin Sci (Lond) 13(1):11–35
30.
Simon AC, Safar ME, Levenson JA et al (1979) An evaluation of large arteries compliance in man. Am J Physiol 237(5):H550–H554PubMed
31.
Mohiaddin RH, Firmin DN, Longmore DB (1993) Age-related changes of human aortic flow wave velocity measured noninvasively by magnetic resonance imaging. J Appl Physiol 74(1):492–497PubMed
32.
Hansen F, Bergqvist D, Mangell P et al (1993) Non-invasive measurement of pulsatile vessel diameter change and elastic properties in human arteries: a methodological study. Clin Physiol 13(6):631–643PubMed
33.
Hahmann M, Richter GM, Schuhmacher H et al (2001) [Post-traumatic dissection of the abdominal aorta]. Radiologe 41(7):590–594CrossRefPubMed
34.
Hansmann HJ, Dobert N, Kucherer H et al. (2000) [Various spiral CT protocols and their significance in the diagnosis of aortic dissections: results of a prospective study]. Rofo 172(11):879-87PubMed
35.
O’Rourke MF (1990) Aging, high blood pressure and disease in humans. In: Nichols WW, O’Rourke MF (eds) McDonald’s Blood flow in arteries. Edward Arnold, London, p 450
36.
Imura T, Yamamoto K, Kanamori K et al (1986) Non-invasive ultrasonic measurement of the elastic properties of the human abdominal aorta. Cardiovasc Res 20(3):208–214PubMedCrossRef
37.
Hahmann M, Boese JM, Leitermann D et al (2001) Measurement of aortic elasticity using ECG-gated multidetector-row CT: an ex-vivo experiment (abstr.). Radiology 221(P):33
38.
Wintersperger B, Jakobs T, Herzog P et al (2005) Aorto-iliac multidetector-row CT angiography with low kV settings: improved vessel enhancement and simultaneous reduction of radiation dose. Eur Radiol 15(2):334–341PubMedCrossRef
39.
Flohr T, Ohnesorge B, Bruder H et al (2003) Image reconstruction and performance evaluation for ECG-gated spiral scanning with a 16-slice CT system. Med Phys 30(10):2650–2662CrossRefPubMed
40.
Taguchi K, Aradate H (1998) Algorithm for image reconstruction in multi-slice helical CT. Med Phys 25(4):550–561CrossRefPubMed
41.
Bundesamt für Strahlenschutz B (2003) Bekanntmachung der diagnostischen Referenzwere für radiologische und nuklearmedizinische Untersuchungen. Bundesanzeiger Nr. 143(Tab 3):17503
Metadata
Title
Age related changes of human aortic distensibility: evaluation with ECG-gated CT
Authors
Marika Ganten
Ute Krautter
Waldemar Hosch
Jochen Hansmann
Hendrik von Tengg-Kobligk
Stefan Delorme
Hans-Ulrich Kauczor
Günter W. Kauffmann
Michael Bock
Publication date
01-03-2007
Publisher
Springer-Verlag
Published in
European Radiology / Issue 3/2007
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-006-0309-z

Other articles of this Issue 3/2007

European Radiology 3/2007 Go to the issue

Gastrointestinal

Computer assisted detection software for CT colonography: effect of sphericity filter on performance characteristics for patients with and without fecal tagging

Gastrointestinal

Assessment of colonic transit time using MRI: a feasibility study

Interpretation Corner

Intramuscular cavernous hemangioma arising from masseter muscle: a diagnostic dilemma (2006: 12b)

Cardiac

Diagnostic value of 64-slice multi-detector row cardiac CTA in symptomatic patients

Cardiac

Value of T2-weighted, first-pass and delayed enhancement, and cine CMR to differentiate between acute and chronic myocardial infarction

Letter to the Editor

Localized nasopharyngeal amyloidosis with remarkable early enhancement on dynamic contrast-enhanced MR imaging