Skip to main content
Top
Published in: European Radiology 11/2006

01-11-2006 | Pediatric

Cyclic contrast-enhanced harmonic voiding urosonography for the evaluation of reflux. Can we keep the cost of the examination low?

Authors: Frederica Papadopoulou, Constantine Tsampoulas, Ekaterini Siomou, Joannie Tzovara, Antigoni Siamopoulou, Stavros C. Efremidis

Published in: European Radiology | Issue 11/2006

Login to get access

Abstract

The purpose of this study was to evaluate whether a second cycle of contrast-enhanced voiding urosonography (VUS) with no added contrast medium (CM) can increase the detection rate of vesicoureteral reflux (VUR). One hundred twelve consecutive children with a mean age of 2.9 years with 224 kidney-ureter units (KUU) underwent two cycles of contrast-enhanced harmonic VUS. The first cycle of VUS was performed with 3.5–12.5 ml of suspension 300 mg/ml SH U 508 A and was followed immediately by a second cycle with only saline without adding CM. VUR was detected in 57 KUU from 44 children (39%) at the first cycle of VUS. Eight of the remaining 68 non-refluxing children (12%) demonstrated VUR at the second cycle (P=0.045). Most cases of missed reflux at the first cycle were grade II (75%). However, in two KUU from two children missed reflux was grade III. In one child reflux (grade II) was missed on the second cycle. Comparing the second cycle of VUS with the first cycle, concordant findings regarding the presence or absence as well as the grade of reflux were found in 94% of KUU. A second cycle of contrast-enhanced harmonic VUS with no added CM discloses significantly more cases of VUR at no additional cost for the examination.
Literature
1.
go back to reference Smellie JM, Hodson CJ, Edwards D, Normand ICS (1964) Clinical and radiological features of urinary infection in childhood. Br Med J 2:1222–1226PubMedCrossRef Smellie JM, Hodson CJ, Edwards D, Normand ICS (1964) Clinical and radiological features of urinary infection in childhood. Br Med J 2:1222–1226PubMedCrossRef
2.
go back to reference Tanagho EA, Hutch JA, Meyers FH, Rambo ON Jr (1965) Primary vesicoureteral reflux: experimental studies of its etiology. Br J Urol 93:165–176 Tanagho EA, Hutch JA, Meyers FH, Rambo ON Jr (1965) Primary vesicoureteral reflux: experimental studies of its etiology. Br J Urol 93:165–176
3.
go back to reference Lebowitz RL, Colodny AH (1973) Urinary tract infection in children. Crit Rev Clin Radiol Nucl Med 4:457–475 Lebowitz RL, Colodny AH (1973) Urinary tract infection in children. Crit Rev Clin Radiol Nucl Med 4:457–475
4.
go back to reference Noe NH, Wyatt RJ, Peeden JN, Rivas ML (1992) The transmission of vesicoureteral reflux from parent to child. J Urol 148:1869–1871PubMed Noe NH, Wyatt RJ, Peeden JN, Rivas ML (1992) The transmission of vesicoureteral reflux from parent to child. J Urol 148:1869–1871PubMed
5.
go back to reference Noe NH (1992) The long term results of prospective sibling reflux screening. J Urol 148:1739–1742PubMed Noe NH (1992) The long term results of prospective sibling reflux screening. J Urol 148:1739–1742PubMed
6.
go back to reference Zerin JM, Ritchey ML, Chang ACH (1993) Incidental vesicoureteral reflux in neonates with antenatally detected hydronephrosis and other abnormalities. Radiology 187:157–160PubMed Zerin JM, Ritchey ML, Chang ACH (1993) Incidental vesicoureteral reflux in neonates with antenatally detected hydronephrosis and other abnormalities. Radiology 187:157–160PubMed
7.
go back to reference Song JT, Ritchey ML, Zerin MJ, Bloom DA (1995) Incidence of vesicoureteral reflux in children with unilateral renal agenesis. J Urol 153:1249–1251PubMedCrossRef Song JT, Ritchey ML, Zerin MJ, Bloom DA (1995) Incidence of vesicoureteral reflux in children with unilateral renal agenesis. J Urol 153:1249–1251PubMedCrossRef
8.
go back to reference Lebowitz RL, Blickman JG (1983) The coexistence of obstruction and reflux. Am J Roentgenol 140:231–238 Lebowitz RL, Blickman JG (1983) The coexistence of obstruction and reflux. Am J Roentgenol 140:231–238
9.
go back to reference Scott JE, Swallow V, Coulthard MG, Lambert HJ, Lee RE (1997) Screening of newborn babies for familial ureteric reflux. Lancet 350:396–400PubMedCrossRef Scott JE, Swallow V, Coulthard MG, Lambert HJ, Lee RE (1997) Screening of newborn babies for familial ureteric reflux. Lancet 350:396–400PubMedCrossRef
10.
go back to reference Paltiel HJ, Rupich RC, Kiruluta HG (1992) Enhanced detection of vesicoureteral reflux in infants and children with use of cyclic voiding cystourethrography. Radiology 184:753–755PubMed Paltiel HJ, Rupich RC, Kiruluta HG (1992) Enhanced detection of vesicoureteral reflux in infants and children with use of cyclic voiding cystourethrography. Radiology 184:753–755PubMed
11.
go back to reference Papadopoulou F, Efremidis S, Oiconomou A, Badouraki M, Panteleli M, Papachristou F, Soteriou I (2002) Cyclic voiding cystourethrography: is vesicoureteral reflux missed with standard voiding cystourethrography? Eur Radiol 12:666–670PubMedCrossRef Papadopoulou F, Efremidis S, Oiconomou A, Badouraki M, Panteleli M, Papachristou F, Soteriou I (2002) Cyclic voiding cystourethrography: is vesicoureteral reflux missed with standard voiding cystourethrography? Eur Radiol 12:666–670PubMedCrossRef
12.
go back to reference Jequier S, Jequier J (1989) Reliability of voiding cystourethrography to detect reflux. Am J Roentgenol 153:807–810 Jequier S, Jequier J (1989) Reliability of voiding cystourethrography to detect reflux. Am J Roentgenol 153:807–810
13.
go back to reference Willi V, Treves S (1983) Radionuclide voiding cystography. Urol Radiol 5:161–173PubMed Willi V, Treves S (1983) Radionuclide voiding cystography. Urol Radiol 5:161–173PubMed
14.
go back to reference Lebowitz RL (1992) The detection and characterization of vesicoureteral reflux in the child. J Urol 148:1640–1642PubMed Lebowitz RL (1992) The detection and characterization of vesicoureteral reflux in the child. J Urol 148:1640–1642PubMed
15.
go back to reference Bosio M (1998) Cystosonography with echocontrast: a new imaging modality to detect vesicoureteric reflux in children. Pediatr Radiol 28:250–255PubMedCrossRef Bosio M (1998) Cystosonography with echocontrast: a new imaging modality to detect vesicoureteric reflux in children. Pediatr Radiol 28:250–255PubMedCrossRef
16.
go back to reference Darge K, Troeger J, Duetting T, Zieger B, Rohrschneider W, Moehring K, Weber C, Toenshoff B (1999) Reflux in young patients: comparison of voiding US of the bladder and retrovesical space with echo enhancement versus voiding cystourethrography for diagnosis. Radiology 210:201–207PubMed Darge K, Troeger J, Duetting T, Zieger B, Rohrschneider W, Moehring K, Weber C, Toenshoff B (1999) Reflux in young patients: comparison of voiding US of the bladder and retrovesical space with echo enhancement versus voiding cystourethrography for diagnosis. Radiology 210:201–207PubMed
17.
go back to reference Farina R, Arena C, Pennisi F, Di Benedetto V, Politi G, Di Benedetto A (2000) Vesico-ureteral reflux: diagnosis and staging with voiding color doppler US. Preliminary experience. Eur J Radiol 35:49–53PubMedCrossRef Farina R, Arena C, Pennisi F, Di Benedetto V, Politi G, Di Benedetto A (2000) Vesico-ureteral reflux: diagnosis and staging with voiding color doppler US. Preliminary experience. Eur J Radiol 35:49–53PubMedCrossRef
18.
go back to reference Kenda R, Novljan G, Kenig A, Hojker S, Fettich J (2000) Echo-enhanced ultrasound voiding cystography in children: a new approach. Pediatr Nephrol 14:297–300PubMedCrossRef Kenda R, Novljan G, Kenig A, Hojker S, Fettich J (2000) Echo-enhanced ultrasound voiding cystography in children: a new approach. Pediatr Nephrol 14:297–300PubMedCrossRef
19.
go back to reference Berrocal T, Gaya F, Arjonilla A, Lonergan G (2001) Vesicoureteral reflux: diagnosis and grading with echo-enhanced cystography versus voiding cystourethrography. Radiology 221:359–365PubMed Berrocal T, Gaya F, Arjonilla A, Lonergan G (2001) Vesicoureteral reflux: diagnosis and grading with echo-enhanced cystography versus voiding cystourethrography. Radiology 221:359–365PubMed
20.
go back to reference Radmayr C, Klauser A, Pallwein L, Zumadden D, Bartsch G, Frauscher F (2002) Contrast-enhanced reflux sonography in children: a comparison to standard radiological imaging. J Urol 167:1428–1430PubMedCrossRef Radmayr C, Klauser A, Pallwein L, Zumadden D, Bartsch G, Frauscher F (2002) Contrast-enhanced reflux sonography in children: a comparison to standard radiological imaging. J Urol 167:1428–1430PubMedCrossRef
21.
go back to reference Kmetec A, Bren AF, Kandus A, Fettich J, Buturovic-Ponikvar J (2001) Contrast-enhanced ultrasound voiding cystography as a screening examination for vesicoureteral reflux in the follow-up of renal transplant recipients: a new approach. Nephrol Dial Transplant 16:120–123PubMedCrossRef Kmetec A, Bren AF, Kandus A, Fettich J, Buturovic-Ponikvar J (2001) Contrast-enhanced ultrasound voiding cystography as a screening examination for vesicoureteral reflux in the follow-up of renal transplant recipients: a new approach. Nephrol Dial Transplant 16:120–123PubMedCrossRef
22.
go back to reference Escape I, Martinex J, Bastart F, Soltuga C, Sala P (2001) Usefulness of echocystography in the study of vesicoureteral reflux. J Ultrasound Med 20:145–149PubMed Escape I, Martinex J, Bastart F, Soltuga C, Sala P (2001) Usefulness of echocystography in the study of vesicoureteral reflux. J Ultrasound Med 20:145–149PubMed
23.
go back to reference Ascenti G, Chimenz R, Zimbaro G, Mazzioti S, Scribano E, Fede C, Ricca M (2000) Potential role of colour-Doppler cystosonography with echocontrast in the screening and follow-up of vesicoureteral reflux. Acta Paediatr 89:1336–1339PubMedCrossRef Ascenti G, Chimenz R, Zimbaro G, Mazzioti S, Scribano E, Fede C, Ricca M (2000) Potential role of colour-Doppler cystosonography with echocontrast in the screening and follow-up of vesicoureteral reflux. Acta Paediatr 89:1336–1339PubMedCrossRef
24.
go back to reference Valentini AL, Salvaggio E, Manzoni C, Rendeli C, Destilo L, Summaria V, Campioni P, Marano P (2001) Contrast-enhanced gray-scale and color Doppler voiding urosonography versus voiding cystourethrography in the diagnosis and grading of vesicoureteral reflux. J Clin Ultrasound 29:65–71PubMedCrossRef Valentini AL, Salvaggio E, Manzoni C, Rendeli C, Destilo L, Summaria V, Campioni P, Marano P (2001) Contrast-enhanced gray-scale and color Doppler voiding urosonography versus voiding cystourethrography in the diagnosis and grading of vesicoureteral reflux. J Clin Ultrasound 29:65–71PubMedCrossRef
25.
go back to reference Mentzel HJ, Vogt S, Patzer L, Schubert R, John U, Misselwitz J, Kaiser WA (1999) Contrast-enhanced sonography of vesicoureterorenal reflux in children:preliminary results. Am J Roentgenol 173:737–740 Mentzel HJ, Vogt S, Patzer L, Schubert R, John U, Misselwitz J, Kaiser WA (1999) Contrast-enhanced sonography of vesicoureterorenal reflux in children:preliminary results. Am J Roentgenol 173:737–740
26.
go back to reference Darge K, Moeller RT, Trusen A, Butter F, Gordjani N, Riedmiller H (2005) Diagnosis of vesicoureteral reflux with low-dose contrast-enhanced harmonic ultrasound imaging. Pediatr Radiol 35:73–78PubMedCrossRef Darge K, Moeller RT, Trusen A, Butter F, Gordjani N, Riedmiller H (2005) Diagnosis of vesicoureteral reflux with low-dose contrast-enhanced harmonic ultrasound imaging. Pediatr Radiol 35:73–78PubMedCrossRef
27.
go back to reference Darge K, Zieger B, Rohrscheider W,Ghods S, Wunsch R, Troeger J (2001) Contrast-enhanced harmonic imaging for the diagnosis of vesicoureteral reflux in pediatric patients. Am J Roentgenol 177:1411–1415 Darge K, Zieger B, Rohrscheider W,Ghods S, Wunsch R, Troeger J (2001) Contrast-enhanced harmonic imaging for the diagnosis of vesicoureteral reflux in pediatric patients. Am J Roentgenol 177:1411–1415
28.
go back to reference Kopitzko A, Cornely D, Reither K, Wolf K, Albrecht T (2004) Low contrast dose voiding urosonography in children with phase inversion imaging. Eur Radiol 14:2290–2296PubMedCrossRef Kopitzko A, Cornely D, Reither K, Wolf K, Albrecht T (2004) Low contrast dose voiding urosonography in children with phase inversion imaging. Eur Radiol 14:2290–2296PubMedCrossRef
29.
go back to reference Kenda RB, Kenig A, Novljan G, Ponikvar R, Ponikvar JB (2001) Cyclic voiding urosonography for detecting vesicoureteric reflux in renal transplant recipients. Nephrol Dial Transplant 16:2229–2231PubMedCrossRef Kenda RB, Kenig A, Novljan G, Ponikvar R, Ponikvar JB (2001) Cyclic voiding urosonography for detecting vesicoureteric reflux in renal transplant recipients. Nephrol Dial Transplant 16:2229–2231PubMedCrossRef
30.
go back to reference Novljan G, Kenig A, Rus R, Kenda RB (2003) Cyclic voiding urosonography in detecting vesicoureteral reflux in children. Pediatr Nephrol 18:992–995PubMedCrossRef Novljan G, Kenig A, Rus R, Kenda RB (2003) Cyclic voiding urosonography in detecting vesicoureteral reflux in children. Pediatr Nephrol 18:992–995PubMedCrossRef
31.
go back to reference Berger RM, Maizels M, Moran GC, Conway JJ, Firlit CF (1983) Bladder capacity (ounces) equals age (years) plus 2 predicts normal bladder capacity and aids in diagnosis of abnormal voiding patterns. J Urol 129:347–352PubMed Berger RM, Maizels M, Moran GC, Conway JJ, Firlit CF (1983) Bladder capacity (ounces) equals age (years) plus 2 predicts normal bladder capacity and aids in diagnosis of abnormal voiding patterns. J Urol 129:347–352PubMed
32.
go back to reference Darge K, Troeger J (2002) Vesicoureteral reflux grading in contrast-enhanced voiding urosonography. Eur J Radiol 43:122–128PubMedCrossRef Darge K, Troeger J (2002) Vesicoureteral reflux grading in contrast-enhanced voiding urosonography. Eur J Radiol 43:122–128PubMedCrossRef
33.
go back to reference Hutch JA (1961) Theory of maturation of the intravesical ureter. J Urol 86:534–538PubMed Hutch JA (1961) Theory of maturation of the intravesical ureter. J Urol 86:534–538PubMed
34.
go back to reference Siamplis D, Vasiou K, Giarmenitis S, Frimas K, Zavras G, Fezoulidis I (1996) Sonographic detection of vesicoureteral reflux with fluid and air cystography. Comparison with VCUG. Rofo Fortschr Geb Roentgenstr Neuen Bildgeb Verfahr 165:166–169CrossRef Siamplis D, Vasiou K, Giarmenitis S, Frimas K, Zavras G, Fezoulidis I (1996) Sonographic detection of vesicoureteral reflux with fluid and air cystography. Comparison with VCUG. Rofo Fortschr Geb Roentgenstr Neuen Bildgeb Verfahr 165:166–169CrossRef
35.
go back to reference Hanbury DC, Coulden RA, Farman P, Sherwood J (1990) Ultrasound cystography in the diagnosis of vesicoureteral reflux. Br J Urol 65:250–253PubMed Hanbury DC, Coulden RA, Farman P, Sherwood J (1990) Ultrasound cystography in the diagnosis of vesicoureteral reflux. Br J Urol 65:250–253PubMed
36.
go back to reference Kaneko K, Kuwatsuru R, Fukuda Y, Yamataka A, Yabuta K, Katayama H, Miyano T (1994) Contrast sonography for detection of vesicoureteral reflux. Lancet 344:687PubMedCrossRef Kaneko K, Kuwatsuru R, Fukuda Y, Yamataka A, Yabuta K, Katayama H, Miyano T (1994) Contrast sonography for detection of vesicoureteral reflux. Lancet 344:687PubMedCrossRef
37.
go back to reference Atala A, Ellsworth P, Share J, Paltiel H, Walker RD, Retic AB (1998) Comparison of sonicated albumin enhanced sonography to fluoroscopic and radionuclide voiding cystography for detecting vesicoureteral reflux. J Urol 160:1820–1822PubMedCrossRef Atala A, Ellsworth P, Share J, Paltiel H, Walker RD, Retic AB (1998) Comparison of sonicated albumin enhanced sonography to fluoroscopic and radionuclide voiding cystography for detecting vesicoureteral reflux. J Urol 160:1820–1822PubMedCrossRef
38.
Metadata
Title
Cyclic contrast-enhanced harmonic voiding urosonography for the evaluation of reflux. Can we keep the cost of the examination low?
Authors
Frederica Papadopoulou
Constantine Tsampoulas
Ekaterini Siomou
Joannie Tzovara
Antigoni Siamopoulou
Stavros C. Efremidis
Publication date
01-11-2006
Publisher
Springer-Verlag
Published in
European Radiology / Issue 11/2006
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-006-0253-y

Other articles of this Issue 11/2006

European Radiology 11/2006 Go to the issue