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01-10-2006 | Hepatobiliary-Pancreas

Encapsulated hepatocellular carcinoma: CT-pathologic correlations

Authors: Jae Hoon Lim, Dongil Choi, Cheol Keun Park, Won Jae Lee, Hyo Keun Lim

Published in: European Radiology | Issue 10/2006

Abstract

This study is a retrospective evaluation of the correlations between the presence and integrity of the capsule of nodular hepatocellular carcinomas (HCC) by dynamic CT and histopathology, with histopathologic evidence of tumor propagation to surrounding hepatic parenchyma. Dynamic CT scans of 75 nodular HCCs in 73 patients (61 men, 12 women; age range, 32–81; mean, 53) were evaluated regarding capsule visualization and integrity. Histopathologic findings of HCCs in resected specimens were correlated with the presence of a capsule, tumor invasion onto the capsule, and with the presence of microvascular emboli in the surrounding liver parenchyma. On histopathologic examination, capsules were present in 57 of 75 nodular HCCs; the capsules were invaded by tumor in 18 nodules and there were microvascular emboli around the nodular HCC in 49 cases. Capsule visualization by CT was correlated with the presence of capsule by histopathology (P<0.001). Disruption of capsule by CT was correlated with tumor invasion by histopathology (P=0.003) and with microvascular tumor emboli (P<0.001). The presence and structural integrity of HCC capsules on CT was closely correlated with the presence of capsule on histopathology and the absence of microvascular tumor emboli.

Okuda K, Musha H, Nakajima Y et al (1977) Clinicopathologic features of encapsulated hepatocellular carcinoma. A study of 26 cases. Cancer 40:1240–1245PubMedCrossRef

Ros PR, Murphy BJ, Buck JL et al (1990) Encapsulated hepatocellular carcinoma: radiologic findings and pathologic correlation. Gastrointest Radiol 15:233–237PubMedCrossRef

Ng IO, Lai EC, Ng MM, Fan ST (1992) Tumor encapsulation in hepatocellular carcinoma. A pathologic study of 189 cases. Cancer 70:45–49PubMedCrossRef

Nagao T, Inone S, Goto S et al (1987) Hepatic resection for hepatocellular carcinoma: clinical features and long-term prognosis. Ann Surg 205:33–40PubMedCrossRef

Kemeny F, Vadrot J, Wu A, Smadja C, Meakins JL, Franco D (1989) Morphological and histological features of resected hepatocellular carcinoma in cirrhotic patients in the West. Hepatology 9:253–257PubMedCrossRef

Franco D, Capussotti S, Smadja C et al (1990) Resection of hepatocellular carcinomas. Results in 72 European patients with cirrhosis. Gastroenterology 98:733–738PubMed

Lee CS, Hwan LY, Beasly RP, Hsu HC, Lee HS, Lin TY (1988) Prognostic significance of histologic findings in resected small hepatocellular carcinoma. Acta Chir Scand 154:199–203PubMed

Lim JH, Jang HJ, Kim EY, Park CK, Joh JW, Kim YI (2000) Early recurring hepatocellular carcinoma after partial hepatic resection: preoperative CT findings. Korean J Radiol 1:38–42PubMedCrossRef

Shirabe K, Kanematsu T, Matsumata T, Adachi E, Akazawa K, Surgimachi K (1991) Factors linked to early recurrence of small hepatocellular carcinoma after hepatectomy: univariate and multivariate analysis. Hepatology 14:802–805PubMedCrossRef

10.

Nagasue N, Uchida M, Makino Y et al (1993) Incidence and factors associated with intrahepatic recurrence following resection of hepatocellular carcinoma. Gastroenterology 105:488–494PubMed

11.

Nagasue N (1998) Liver resection for hepatocellular carcinoma: indications, techniques, complications, and prognostic factors. J Hepatobiliary Pancreat Surg 5:7–13PubMedCrossRef

12.

Fournier LS, Cuenod CA, de Bazelaire C et al (2004) Early modifications of hepatic perfusion measured by functional CT in a rat model of hepatocellular carcinoma using blood pool contrast agent. Eur Radiol 14:2125–2133PubMedCrossRef

13.

Wakasa K, Sakurai M, Kuruda C et al (1990) Effect of transcatheter arterial embolization on the boundary architecture of hepatocellular carcinoma. Cancer 65:913–919PubMedCrossRef

14.

Izumi R, Shimizu K, Ii T et al (1994) Prognostic factors of hepatocellular carcinoma in patients undergoing hepatic resection. Gastroenterology 106:720–727PubMed

15.

Predictive factors for long-term prognosis after partial hepatectomy for patients with hepatocellular carcinoma in Japan (1994) The liver cancer study group of Japan. Cancer 74:2772–2780CrossRef

16.

Tasai TJ, Chau GY, Lai EC et al (2000) Clinical significance of microscopic tumor venous invasion in patients with resectable hepatocellular carcinoma. Surgery 127:603–608CrossRef

17.

Kanematsu T, Takenaka K, Matsumata T, Furuta T, Sugimachi K, Inokuchi K (1984) Limited hepatic resection effective for selected cirrhotic patients with primary liver cancer. Ann Surg 199:51–56PubMedCrossRef

18.

Yamamoto M, Matsuda M, Iimuro Y, Fuji H, Nagahori K, Ainota K (1993) Intrahepatic distant metastasis and metachronous multicentric occurrence in solitary hepatocellular carcinoma of less than five centimeters in diameter. Surg Today 23:969–978PubMedCrossRef

19.

Nagao T, Inoue S, Yochimi F et al (1990) Postoperative recurrence of hepatocellular carcinoma. Ann Surg 211:28–33PubMedCrossRef

20.

Chen MF, Whang TL, Jeng LB, Wang CS, Jan YY, Chen SC (1994) Postoperative recurrence of hepatocellular carcinoma: two hundred five consecutive patients who underwent hepatic resection in 15 years. Arch Surg 129:738–742PubMed

21.

Lai EC, Ng IO, Ng MM et al (1990) Long-term results of resection for large hepatocellular carcinoma: a multivariate analysis of clinicopathological features. Hepatology 11:815–818PubMedCrossRef

22.

Ueda K, Matsui O, Kawamori Y et al (1998) Hypervascular hepatocellular carcinoma: evaluation of hemodynamics with dynamic CT during hepatic arteriography. Radiology 206:161–166PubMed

23.

Grazioli L, Ollivetti L, Fugazzola C et al (1999) The capsule in hepatocellular carcinoma: correlation between dynamic MR imaging and pathology. Eur Radiol 9:62–67PubMedCrossRef

24.

Nakashima T (1987) Vascular changes and hemodynamics in hepatocellular carcinoma. In: Okuda K, Peters RL (eds) Hepatocellular carcinoma. Wiley, New York, pp 169–203

25.

Matsumata T, Kanematsu T, Tabenaka K, Yoshida Y, Nishizaki T, Sugimachi K (1989) Patterns of intrahepatic recurrence after curative resection of hepatocellular carcinoma. Hepatology 9:457–460PubMedCrossRef

26.

Okada S, Shimada K, Yamamoto J et al (1994) Predictive factors for postoperative recurrence of hepatocellular carcinoma. Gastroenterology 106:1618–1624PubMed

Title: Encapsulated hepatocellular carcinoma: CT-pathologic correlations
Authors: Jae Hoon Lim
Dongil Choi
Cheol Keun Park
Won Jae Lee
Hyo Keun Lim
Publication date: 01-10-2006
Publisher: Springer-Verlag
Published in: European Radiology / Issue 10/2006
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-006-0203-8

At a glance: The STEP trials

Springer Medicine

Encapsulated hepatocellular carcinoma: CT-pathologic correlations

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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