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01-01-2006 | Experimental

Detection of focal renal perfusion defects in rabbits after sulphur hexafluoride-filled microbubble injection at low transmission power ultrasound insonation

Authors: Emilio Quaia, Salvatore Siracusano, Alessandro Palumbo, Stefano Ciciliato, Stefania Rossi, Stefano Bruni, Rossana Bussani, Maria Cova

Published in: European Radiology | Issue 1/2006

Abstract

The aim of this study was to assess the feasibility of contrast-enhanced ultrasound (US) at low transmission power insonation for diagnosis of focal renal perfusion defects (RPDs) in rabbits. In seven adult New Zealand White rabbits focal RPDs were induced by polyvinyl alcohol embolizing particles (150–250 μm in diameter) injected into the abdominal aorta. Three other rabbits that were not subjected to embolization were considered as controls. Both kidneys were insonated at baseline and after injection of sulphur hexafluoride-filled microbubbles at low transmission power (mechanical index 0.09–0.12). One sonologist assessed on-site RPD dimensions and conspicuity (visual score 0–4). Digital cine-clips were also reviewed off-site by two other independent readers, blinded, who assigned a confidence level (grades 1–5) for the RPD diagnosis. At on-site analysis RPDs appeared as focal areas of absent or diminished enhancement with a median visual conspicuity score=4. At off-site analysis RPDs >6 mm in diameter were identified at contrast-enhanced US, and the confidence in RPD diagnosis improved significantly (P<0.05) after microbubble injection (area under receiver operating characteristic curve 0.615 vs 0.972 by reader 1; 0.720 vs 0.953 by reader 2). Contrast-enhanced US at low transmission power insonation effectively identified RPDs with diameters >6 mm in rabbits.

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Title: Detection of focal renal perfusion defects in rabbits after sulphur hexafluoride-filled microbubble injection at low transmission power ultrasound insonation
Authors: Emilio Quaia
Salvatore Siracusano
Alessandro Palumbo
Stefano Ciciliato
Stefania Rossi
Stefano Bruni
Rossana Bussani
Maria Cova
Publication date: 01-01-2006
Publisher: Springer-Verlag
Published in: European Radiology / Issue 1/2006
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-005-2866-y

At a glance: The STEP trials

Springer Medicine

Detection of focal renal perfusion defects in rabbits after sulphur hexafluoride-filled microbubble injection at low transmission power ultrasound insonation

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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