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European Radiology
Published in: European Radiology 6/2004

01-06-2004 | Oncology

Detection of bone marrow and extramedullary involvement in patients with non-Hodgkin’s lymphoma by whole-body MRI: comparison with bone and 67Ga scintigraphies

Authors: Masami Iizuka-Mikami, Kiyohisa Nagai, Koji Yoshida, Takashi Sugihara, Yoshimasa Suetsugu, Makoto Mikami, Tsutomu Tamada, Shigeki Imai, Yasumasa Kajihara, Masao Fukunaga

Published in: European Radiology | Issue 6/2004

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Abstract

The aim of this study was to evaluate the diagnostic potential of whole-body MRI (WB-MRI) for the detection of bone marrow and extramedullary involvement in patients with non-Hodgkin’s lymphoma. WB-MRI, which was performed on 34 patients, consisted of the recording of T1-weighted spin-echo images and a fast STIR sequence covering the entire skeleton. The WB-MRI findings for bone marrow and extramedullary involvement were compared with those from 67Ga and bone scintigraphies and bone marrow biopsy results. Two MRI specialists reviewed the WB-MRI results and two expert radiologists in the field of nuclear medicine reviewed the bone and 67Ga scintigraphy findings. Bone marrow and extramedullary involvement of non-Hodgkin’s lymphoma were confirmed by follow-up radiographs and CT and/or a histological biopsy. The detection rate of WB-MRI was high. More bone marrow involvement was detected by biopsy, and more lesions were detected by scintigraphies. In total, 89 lesions were detected by WB-MRI, whereas 15 were found by biopsy, 5 by 67Ga scintigraphy, and 14 by bone scintigraphy. WB-MRI could also detect more extramedullary lesions than 67Ga scintigraphy; i.e., 72 lesions were detected by WB-MRI, whereas 54 were discovered by 67Ga scintigraphy. WB-MRI is useful for evaluating the involvement of bone marrow and extramedullary lesions throughout the skeleton in patients with non-Hodgkin’s lymphoma.
Literature
1.
Halliday T, Baxter G (2003) Lymphoma: pictorial review II. Eur Radiol 13:1224–1234PubMed
2.
Ostrowski ML, Unni KK, Banks PM et al (1986) Malignant lymphoma of bone. Cancer 58:2646–2655PubMed
3.
Stiglbauer R, Augustin I, Kramer J et al (1992) MRI in the diagnosis of primary lymphoma of bone: correlation with histopathology. J Comput Assist Tomogr 16:248–253PubMed
4.
Hoane BR, Shields AF, Porter BA et al (1991) Detection of lymphomatous bone marrow involvement with magnetic resonance imaging. Blood 78:728–738PubMed
5.
Lopez-guillermo A, Montserrat E, Bosch F et al (1994) Low-grade lymphoma: clinical and prognostic studies in a series of 143 patients from a single institution. Leuk Lymphoma 15:159–165PubMed
6.
Brunning RD, Bloomfield CD, Mckenna RW et al (1975) Bilateral trephine bone marrow biopsies in lymphoma and other neoplastic diseases. Ann Int Med 82:365–366PubMed
7.
Orzel JA, Sawaf NW, Richardson ML (1988) Lymphoma of the skeleton: scintigraphic evaluation. AJR 150:1095–1099
8.
Ziegels P, Nocaudie M, Huglo D et al (1995) Comparison of technetium-99m methoxyisobutylisonitrile and gallium-67 citrate scanning in the assessment of lymphomas. Eur J Nucl Med 22:126–131PubMed
9.
Bar-Shalom R, Israel O, Epelbaum R et al (1995) Gallium-67 scintigraphy in lymphoma with bone involvement. J Nucl Med 36:446–450PubMed
10.
Segall GM (2001) FDG PET imaging in patients with lymphoma: a clinical perspective. J Nucl Med 42:609–610PubMed
11.
Sandrasegaran K, Robinson PJ, Selby P (1994) Staging of lymphoma in adults. Clin Radiol 49:149–161PubMed
12.
Negendank W, Soulen RL (1993) Magnetic resonance imaging in patients with bone marrow disorders. Leuk Lymphoma 10:287–298PubMed
13.
Coller BS, Chabner BA, Gralnick HR et al (1977) Frequencies and patterns of bone marrow involvement in non-Hodgkin lymphoma: observations on the value of bilateral biopsies in lymphoma and other neoplastic disease. Am J Hematol 3:105–119PubMed
14.
Schoder H, Meta J, Yap C et al (2001) Effect of whole-body (18) F-FDG PET imaging on clinical staging and management of patients with malignant lymphoma. J Nucl Med 42:1139–1143PubMed
15.
Moulopoulos LA, Dimopoulos MA (1997) Magnetic resonance imaging of the bone marrow in hematologic malignancies. Blood 90:2127–2147PubMed
16.
Iizuka M, Nagai K, Tamada T et al (1999) Fundamental study of the detection of metastatic bone tumors with whole-body MR imaging. Nippon Acta Radiol 59:470–472PubMed
17.
Amanuma M, Kozawa E, Heshiki A (1999) Bone marrow survey by MRI using a table-moving technique. Nippon Acta Radiol 59:473–475PubMed
18.
Chan Y, Chan K, Lam W et al (1997) Comparison of whole body MRI and radioisotope bone scintigram for skeletal metastases detection. Chin Med J 110:485–489PubMed
19.
Eustace S, Tello R, DeCarvalho V et al (1997) A comparison of whole-body turbo STIR MR imaging and planar 99mTc-methylene diphosphonate scintigraphy in the examination of patients with suspected skeletal metastases. AJR 169:1655–1661
20.
Tamada T, Nagai K, Iizuka M et al (2000) Comparison of whole-body MR imaging and bone scintigraphy in detection of bone metastases from breast cancer. Nippon Acta Radiol 60:249–254PubMed
21.
Baker LL, Goodman SB, Perkash I et al (1990) Benign versus pathologic compression fractures of vertebral bodies: assessment with conventional spin echo, chemical-shift, and STIR MR imaging. Radiology 174:495–502PubMed
22.
Tardivon A, Vanel D, Munck J-N et al (1997) Magnetic resonance imaging of the bone marrow in lymphomas and leukemias. Leuk Lymphoma 25:55–68PubMed
23.
Bartold SP, Donohoe KJ, Fletcher JW et al (1997) Procedure guideline for Gallium scintigraphy in the evaluation of malignant disease. J Nucl Med 38:990–994PubMed
24.
Frank JA, Ling A, Patronas NJ et al (1990) Detection of malignant bone tumors: MR imaging vs scintigraphy. AJR 155:1043–1048
25.
Eustace S, Tello R, DeCarvalho V et al (1998) Whole-body turbo STIR MRI in unknown primary tumor detection. JMRI 8:751–753PubMed
26.
Steinborn MM, Heuck AF, Tiling R et al (1999) Whole-body bone marrow MRI in patients with metastatic disease to the skeletal system. J Comput Assist Tomogr 23:123–129PubMed
27.
Linden A, Zankovich R, Theissen P et al (1989) Malignant lymphoma: bone marrow imaging versus biopsy. Radiology 173:335–339PubMed
28.
Tunoda S, Takagi S, Tanaka O et al (1997) Clinical and prognostic significance of femoral marrow magnetic resonance imaging in patients with malignant lymphoma. Blood 89:286–290PubMed
29.
Dohner H, Guckel F, Knauf W et al (1989) Magnetic resonance imaging of bone marrow in lymphoproliferative disorders: correlation with bone marrow biopsy. Br J Haematol 73:12–17PubMed
30.
Vande Berg BC, Lecouvet FE, Michaux L et al (1998) Magnetic resonance imaging of the bone marrow in hematological malignancies. Eur Radiol 8:1335–1344PubMed
31.
Jones KM, Unger EC, Granstrom P et al (1992) Bone marrow imaging using STIR at 0.5 and 1.5T. Magn Reson Imaging 10:169–170PubMed
32.
Altehoefer C, Blum U, Bathmann J et al (1997) Comparative diagnostic accuracy of magnetic resonance imaging and immunoscintigraphy for detection of bone marrow involvement in patients with malignant lymphoma. J Clin Oncol 15:1745–1760PubMed
33.
Moore SG, Bisset GS III, Siegel MJ et al (1991) Pediatric musculoskeletal MR imaging. Radiology 179:345–360PubMed
34.
Moore SG, Dawson KL (1990) Red and yellow marrow in the femur: age-related changes in appearance at MR imaging. Radiology 175:219–223PubMed
35.
Moog F, Kotzerke J, Reske SN (1999) FDG PET can replace bone scintigraphy in primary staging of malignant lymphoma. J Nucl Med 40:1407–1413
Metadata
Title
Detection of bone marrow and extramedullary involvement in patients with non-Hodgkin’s lymphoma by whole-body MRI: comparison with bone and 67Ga scintigraphies
Authors
Masami Iizuka-Mikami
Kiyohisa Nagai
Koji Yoshida
Takashi Sugihara
Yoshimasa Suetsugu
Makoto Mikami
Tsutomu Tamada
Shigeki Imai
Yasumasa Kajihara
Masao Fukunaga
Publication date
01-06-2004
Publisher
Springer-Verlag
Published in
European Radiology / Issue 6/2004
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-003-2209-9

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